Adrenomedullin: an important participant in neurological diseases
Adrenomedullin: an important participant in neurological diseases作者机构：College of Life Sciences Laboratory of Neuroendocrinology Provincial Key Laboratory of Developmental Biology and Neuroscience Fujian Normal University
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2020年第15卷第7期
页 面：1199-1207页
核心收录：
基 金：supported by the National Natural Science Foundation of China,No.81400922(to DMW),81571084 the Natural Science Foundation of Fujian Province of China,No.2018J01813(to DMW) the College of Life Sciences of Fujian Normal University of China,No.FZSKG2018016(to DMW)
主 题：adrenomedullin brain injury glia mechanism morphine tolerance neural regeneration neuroprotective effect pathological pain regeneration sensitization target
摘 要：Adrenomedullin,a peptide with multiple physiological functions in nervous system injury and disease,has aroused the interest of *** review summarizes the role of adrenomedullin in neuropathological disorders,including pathological pain,brain injury and nerve regeneration,and their *** a newly characterized pronociceptive mediator,adrenomedullin has been shown to act as an upstream factor in the transmission of noxious information for various types of pathological pain including acute and chronic inflammatory pain,cancer pain,neuropathic pain induced by spinal nerve injury and diabetic *** of glia-neuron signaling networks in the peripheral and central nervous system by adrenomedullin is involved in the formation and maintenance of morphine *** has been shown to exert a facilitated or neuroprotective effect against brain injury including hemorrhagic or ischemic stroke and traumatic brain ***,adrenomedullin can serve as a regulator to promote nerve regeneration in pathological ***,adrenomedullin is an important participant in nervous system diseases.
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