Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

作     者：Wei Dong Wen-Jing Ma Yun-Bao Ma Feng-Jiao Li Tian-Ze Li Yong-Cui Wang Xiao-Feng He Chang-An Geng Xue-Mei Zhang Ji-Jun Chen Wei Dong;Wen-Jing Ma;Yun-Bao Ma;Feng-Jiao Li;Tian-Ze Li;Yong-Cui Wang;Xiao-Feng He;Chang-An Geng;Xue-Mei Zhang;Ji-Jun Chen

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201 China University of Chinese Academy of SciencesBeijing100049 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第19期

页      面：2453-2468页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Key Program of National Natural Science Foundation of China(22137008) the Xingdian Yingcai Project(YNWR-KJLJ-2019-002) the Youth Innovation Promotion Association,CAS(2020386) the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202105AC160021) 

主　　题：Artemzhongdianolides B1-B17 Artemisia zhongdianensis Guaiane-type sesquiter penoid dimers Antihepatoma activity p38MAPK pathway Cancer NMR spectroscopy X-ray diffraction 

摘      要：17 new guaiane-type sesquiterpenoid dimers(GSDs),artemzhongdianolides B1—B17(1—17),were isolated from Artemisia zhongdianensis under the guidance of bioassay,and elucidated by spectral analyses(HRESIMS,1D and 2D NMR,IR,ECD).The absolute configuration of compounds 1,3,7,9,10,and 13 was determined by single-crystal X-ray diffraction ***,artemzhongdianolides B1(1)and B2(2)were the first example of the GSDs fused via a C-13/C-13 single bond,and artemzhongdianolides B3—B17 were[4+2]Diels–Alder adducts of two monomeric *** of the compounds showed antihepatoma cytotoxicity with IC_(50) values ranging from 9.9 to 170.1μmol/***,artemzhongdianolide B9(9)was the most active one against three hepatoma cell lines with IC_(50) values of 13.1μmol/L(HepG2),19.5μmol/L(Huh7),and 19.5μmol/L(SK-Hep-1),and dose-dependently inhibited cell migration and invasion,induced G1 cell cycle arrest and cell apoptosis in HepG2 *** 9 might suppress HepG2 cells via affecting the p38MAPK signaling pathway suggested by machine learning approach,and significantly upregulated expression of phosphorylated p38 validated by Western blot assay.