检索结果-南通市图书馆

An air quality forecasting system in Beijing-Application to the study of dust storm events in China in May 2008

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第1期24卷 102-111页

作者： Benoit Laurent fanny Velay-Lasry richard Ngo Claude Derognat Batrice Marticorena Armand Albergel Laboratoire Inter-universitaire des Systèmes Atmosphriques Laboratorie mixte Paris VII-UPEC-CNRSUMR 7583CrteilFrance ARIA Technologies Boulogne-BillancourtFrance

An air pollution forecast system,ARIA Regional,was implemented in 2007–2008 at the Beijing Municipality Environmental Monitoring Center,providing daily forecast of main pollutant *** chemistry-transport model CHIMERE was coupled with the dust emission model MB95 for restituting dust storm events in springtime so as to improve forecast *** storm events were sporadic but could be extremely intense and then control air quality indexes close to the source areas but also far in the Beijing area.A dust episode having occurred at the end of May 2008 was analyzed in this article,and its impact of particulate matter on the Chinese air pollution index （API） was *** our estimation,about 23 Tg of dust were emitted from source areas in Mongolia and in the Inner Mongolia of China,transporting towards *** episode of dust storm influenced a large part of North China and East China,and also South *** model result was then evaluated using satellite observations and in situ *** simulated daily concentrations of total suspended particulate at 6：00 UTC had a similar spatial pattern with respect to OMI satellite aerosol *** evolution of dust plume was evaluated by comparing dust aerosol optical depth （AOD） calculated from the simulations with AOD derived from MODIS satellite ***,the comparison of reported Chinese API in Beijing with API calculated from the simulation including dust emissions had showed the significant improvement of the model results taking into accountmineral dust correctly.

关键词： dust particulate matter modeling Beijing air quality forecast and analysis system

A new interaction between Abi-1 and βPIX involved in PDGF-activated actin cytoskeleton reorganisation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cell Research 2006年第9期16卷 759-770页

作者： fanny Campa NikolausMachuy AlexanderKlein ThomasRudel Max

Members of the Rho family of GTPases are key regulators of the actin *** particular,activated Rac 1stimulates membrane dorsal ruffle formation in response to platelet-derived growth factor (PDGF).Abl-interactor (Abi)-1 and βPIX,a guanine nucleotide exchange factor for Rac 1,localise at these Rac1-induced actin structures and playimportant roles in the induction of membrane dorsal ruffling in response to PDGF in ***,we demonstratea novel interaction between Abi-1 and βPIX using the yeast two-hybrid system,in vitro pull-down assays,and in vivoco-immunoprecipitation *** vitro,the C-terminal fragment of ]3PIX interacted with Abi-1,while in vivo theN-terminal fragment of βPIX interacted with *** biological function of this interaction was investigated in mousefibroblasts in response to PDGF ***-1 and βPIX co-localised in the cytoplasm and to membrane dorsalruffles after PDGF *** show that the co-expression of Abi-1 and truncated forms of βPIX in mouse fibroblastsblocked PDGF-induced membrane dorsal ***,these results show that the interaction between Abi-1 andβPIX is involved in the formation of growth factor-induced membrane dorsal ruffles.

关键词： βPIX Abi-1 PDGF membrane dorsal ruffling cytoskeleton

Protein deacetylases and axonal regeneration

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第6期10卷 870-871页

作者： fanny Ng Bor Luen Tang Department of Biochemistry Yong Loo Lin School of MedicineNational University Health System Graduate School for Integrative Sciences and Engineering National University of Singapore

A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system （CNS） neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An extensive body of work has revealed mechanisms whereby the myelin-associated inhibitors and extracellular matrix chondroitin sulfate proteoglycans promote collapse of axonal growth cones or repel their advances （Lee and Zheng, 2012）. The intrinsic axonal regeneration capacity of an injured neuron is, however,

关键词： Protein deacetylases axonal regeneration

SCHOOL DIFFICULTIES in Children Cancer Survivors: A Narrative Review and a Teacher Point-of-View

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Psycho-Oncologie 2024年第2期18卷 109-115页

作者： fanny Delehaye Caroline Fayet Julien Lejeune Department of Medicine University of CaenCaen14000France Department of Pediatric Oncology University Hospital of CaenCaen14000France Laboratory“ANTICIPE”UNIT U1086 INSERM Caen14000France Department of Pediatric Oncology Clocheville University HospitalTours37000France

School difficulties are common in children cancer survivors and may be prognostic for the success of the patient social reintegration after the ***,we carry out a narrative review of the literature from 2001 to 2022 to assess the school difficulties of these patients,the predictive factors of these difficulties,and the possible long-term *** punctuate this review the practical point-of-view of a teacher dedicated to our hospital,who works with children with chronic diseases such as ***,we expose possible barriers and solutions to improve the scholar reintegration and limit the impact of cancer on the academic achievement.

关键词： Cancer children school

Developing Audiences Through Outreach and Education in the Major Performing Arts Institutions of Hong Kong:Towards a Conceptual Framework

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fudan Journal of the Humanities and Social Sciences 2021年第3期14卷 345-366页

作者： fanny Ming Yan Chung Cultural Management Programme Faculty of ArtsThe Chinese University of Hong KongRm 206Leung Kau Kui BuildingShatinNew TerritoriesHong KongChina

The public's participation rate in performing arts in Hong Kong has historically been low,and the Arts Participation and Consumption Survey in 2018 indicated that the primary reason was 4a lack of interest*and that education in the arts could increase public *** survey data clearly indicate the significance of education as a driver to develop future *** are nine major performing arts organisations funded by the Hong Kong government,and they share the responsibility of shaping the performing arts *** study explored the role of outreach and education within these major performing arts organisations and how they impact audience *** addition to document analysis and fieldwork,the researcher interviewed five cultural leaders from the nine performing arts *** findings of this study indicate that while the organisations*outreach and education engagement help to achieve various important educational goals,direct impact on ticket sales is not easily quantifiable and may occur in the long *** study concludes by offering a proposed conceptual framework for outreach and education when they are positioned in non-profit performing arts *** four layers in the proposed conceptual framework involve cognitive,affective,ethical,and behavioural *** contributes to reframing the conceptualisation of audience development for the performing arts and sheds new light on the future of outreach and education in arts organisations and policymaking in arts and culture,with far-reaching implications for other non-profit cultural organisations in Hong Kong and globally.

关键词： Outreach Arts education Performing arts Audience development Cultural management

Translating Culture-Bound Elements:A Case Study of Traditional Chinese Theatre in the Socio-Cultural Context of Hong Kong

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fudan Journal of the Humanities and Social Sciences 2021年第3期14卷 393-415页

作者： fanny Ming Yan Chung Cultural Management Programme Faculty of ArtsThe Chinese University of Hong KongRm 206Leung Kau Kui BuildingShatinNew TerritoriesHong Kong

This study explores the controversy surrounding the translation of the name of a new cultural infrastructure in Hong Kong,specifically related to the cultural heritage of traditional Chinese *** first performing arts landmark in Hong Kong's West Kowloon Cultural District was named the Xiqu Centre;the term xiqu is a Hanyu pinyin representing traditional Chinese *** this translation issue has been intensely debated for over a decade,it remains unexplored in the *** reference to Venuti's translation strategies of foreignization and domestication,this study examines the Hong Kong public's views on the translation of the name of this cultural landmark and the underlying drivers of their *** uses internet-based surveys,semi-structured interviews with the public,and interviews with experts as data *** results revealed that factors of(1)aesthetics and artistry,(2)cultural identity,and(3)publicity and internationalization have contributed to public *** study^findings shed new light on how translation interacts with cultural,social,and political factors by examining how Hong Kong’s unique historical relationship with China and the West has played a role in this translation *** findings have significant implications for the translation of culture-bound elements and the transmission of cultural heritage in Hong Kong and worldwide.

关键词： Translation Traditional Chinese theatre Xiqu Chinese opera Cultural identity

Disrupted regulatory T cell homeostasis in inflammatorybowel diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第3期22卷 974-995页

作者： Christophe Pedros fanny Duguet Abdelhadi Saoudi Marianne Chabod Division of Cell Biology La Jolla Institute for Allergy and ImmunologyLa JollaCA 92307United States UMR Inserm U1043F-31300 ToulouseFrance UMR CNRS U5282F-31300 ToulouseFrance Universitéde Toulouse UPSCentre de Physiopathologie de Toulouse PurpanF-31300 ToulouseFrance Epidermis Differentiation and Rheumatoid Autoimmunity Laboratory UMR CNRS 5165INSERM U 1056Toulouse III UniversityF-31300 ToulouseFrance

In the gut, where billions of non-self-antigens from the food and the microbiota are present, the immune response must be tightly regulated to ensure both host protection against pathogenic microorganisms and the absence of immune-related pathologies. It has been well documented that regulatory T cells(Tregs) play a pivotal role in this context. Indeed, Tregs are able to prevent excessive inflammation, which can lead to the rupture of intestinal homeostasis observed in inflammatory bowel diseases(IBDs). Both the worldwide incidence and prevalence of such diseases have increased throughout the latter part of the 20^(th) century. Therefore, it is crucial to understand how Tregs suppress the colitogenic immune cells to establish new treatments for patients suffering from IBDs. In this review, we will first summarize the results obtained in animal model studies that highlight the importance of Tregs in maintaining intestinal homeostasis and describe the specific suppressive mechanisms involved. Next, our current knowledge about Tregs contribution to human IBDs will be reviewed, as well as the current therapeutic perspective on using Tregs for clinical IBD treatment and the challenges that remain to be resolved to ensure both the safety and effectiveness of these therapies in targeting this critical immune-regulatory cell population.

关键词： Regulatory T cells Foxp3 Gut Inflammatorybowel disease Colitis

Management of small hepatocellular carcinoma in cirrhosis:Focus on portal hypertension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第8期19卷 1193-1199页

作者： Virginia Hernandez-Gea fanny Turon Annalisa Berzigotti Augusto Villanueva Hepatocellular Carcinoma Translational Research Laboratory Barcelona-Clinic Liver Cancer GroupInstitut d'Investigacions Biomediques August Pi i SunyerLiver UnitHospital Clinic08036 BarcelonaSpain Hepatic Hemodynamic Laboratory Liver UnitHospital ClinicUniversity of Barcelona08036 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto Carlos Ⅲ08036 BarcelonaSpain

The incidence of hepatocellular carcinoma(HCC) is rising worldwide being currently the fifth most common cancer and third cause of cancer-related *** detection of HCC through surveillance programs have enabled the identification of small nodules with higher frequency,and nowadays account for 10%-15% of patients diagnosed in the West and almost 30% in *** with small HCC can be candidates for potential curative treatments:liver transplantation,surgical resection and percutaneous ablation,depending on the presence of portal hypertension and *** review will analyze recent advancements in the clinical management of these individuals,focusing on issues related to the role of portal hypertension,the debate between resection and ablative therapies and the future impact of molecular technologies.

关键词： Portal hypertension Hepatic venous pressure gradient Clinically significant portal hypertension Liver stiffness Liver cancer Hepatocellular carcinoma Resection Radiofrequency ablation Percutaneous ethanol injection

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2014年第1期3卷 397-413页

作者： Kang Yiu Lai Wing Yiu George Ng Fan fanny Cheng Department of Intensive Care Queen Elizabeth HospitalHKSARB630 Gascoigne RdKowloonHong Kong SARChina Department of Medicine Queen Elizabeth HospitalHKSARKowloonHong Kong SAR China

The recent outbreak of the human Zaire ebolavirus(EBOV)epidemic is spiraling out of control in West *** EBOV hemorrhagic fever has a case fatality rate of up to 90%.The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention,with no approved therapies and vaccines available for its treatment apart from supportive *** several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial,the current epidemic might be outpacing the speed at which drugs and vaccines can be *** all viruses,the EBOV largely relies on host cell factors and physiological processes for its entry,replication,and *** have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal *** of the therapeutic agents in this review are directed against non-mutable targets of the host,which is independent of viral *** medications are approved by the Food and Drug Administration(FDA)for the treatment of other *** are available and stockpileable for immediate *** may also have a complementary role to those therapeutic agents under development that are directed against the mutable targets of the EBOV.

关键词： Ebola virus Non-mutable host cell therapeutic targets for Ebola virus Cocktail therapeutic intervention for RNA virus