Protein deacetylases and axonal regeneration

作     者：Fanny Ng Bor Luen Tang 

作者机构：Department of BiochemistryYong Loo Lin School of MedicineNational University Health System Graduate School for Integrative Sciences and EngineeringNational University of Singapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第6期

页      面：870-871页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Graduate School for Integrative Sciences and Engineering National University of Singapore 

主　　题：蛋白聚糖类 神经元 生长锥 髓鞘 细胞外基质 胰岛素 中枢神经系统 周围神经 成年人 人类 

摘      要：A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system （CNS） neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An extensive body of work has revealed mechanisms whereby the myelin-associated inhibitors and extracellular matrix chondroitin sulfate proteoglycans promote collapse of axonal growth cones or repel their advances （Lee and Zheng, 2012）. The intrinsic axonal regeneration capacity of an injured neuron is, however,