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World Journal of Gastroenterology 2016年第47期22卷 10325-10340页

作者： Orsolya Galamb Alexandra kalmár barbara kinga barták árpád V Patai katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár Molecular Medicine Research Group Hungarian Academy of Sciences 2~(nd) Department of Internal Medicine Semmelweis University 1~(st) Department of Paediatrics Semmelweis University

AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related "epigenetic clock" genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture *** Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P kk3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased S

关键词： DNA methylation Aging Colorectal cancer Adenoma Epigenetic drift Epigenetic clock Secreted frizzled related protein 1

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Evaluation of the nutritional status of patients with liver cirrhosis

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World Journal of Hepatology 2023年第7期15卷 914-924页

作者： barbara Janota Aneta krupowicz kinga Noras Ewa Janczewska Department of Basic Medical Sciences Faculty of Public Health in BytomMedical University of Silesia in KatowiceBytom 41-902Poland ID Clinic Mysłowice 41-400Poland Department of Biometry Warsaw University of Life SciencesWarsaw 02-787Poland

BACkGROUND Progressive malnutrition coexists with liver diseases,particularly in patients with *** diagnosis of malnutrition in patients with advanced stages of chronic liver disease and the implementation of appropriate nutritional treatment for malnourished patients should be an integral part of the therapeutic *** To evaluate the nutritional status of patients with various severities of advanced liver fibrosis,using various nutritional status *** This study involved 118 patients with liver cirrhosis who were classified into three groups according to their Child-Pugh *** nutritional status of the patients in each group was assessed using different *** average values obtained from the measurements were calculated for each research *** influence of disease stage on the examined parameters of nutritional status was determined using one-way analysis of *** investigate the relationship between the parameters determining nutritional status and the stage of disease advancement,a correlation analysis was *** The Child-Pugh A group had the highest mean body weight(76.42 kg),highest mean body mass index(BMI)(26.72 kg/m²),and largest mean arm circumference(27.64 cm).In the Child-Pugh B group,the mean scores of all examined variables were lower than those of the Child-Pugh A group,whereas the mean body weight and BMI of the Child-Pugh C group were higher than those of the Child-Pugh B *** was a very strong correlation between the Child-Pugh classification and subjective global assessment score;a very strong correlation between the Child-Pugh classification and arm circumference;a strong correlation between the Child-Pugh classification and body weight,albumin concentration,fat-free mass index,muscle mass index,phase angle,and BMI;and an average correlation between Child-Pugh classification and fat mass ***,these indicators deteriorated with disease *** Advanced li

关键词： Liver cirrhosis Fibrosis Nutritional status Malnourishment Sarcopenia

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Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第3期16卷 167-178页

作者： kinga SALAT barbara FILIPEk Department of Pharmacodynamics Faculty of PharmacyJagiellonian University

The aim of this research was to assess the antinociceptive activity of the transient receptor potential （TRP） channel TRPV1, TRPM8, and TRPA1 antagonists in neurogenic, tonic, and neuropathic pain models in mice. For this purpose, TRP channel antagonists were administered into the dorsal surface of a hind paw 15 min before capsaicin, allyl isothiocyanate （AITC）, or formalin. Their antiallodynic and antihyperalgesic efficacies after intraperitoneal ad- ministration were also assessed in a paclitaxel-induced neuropathic pain model. Motor coordination of paclitaxel- treated mice that received these TRP channel antagonists was investigated using the rotarod test. TRPV1 antagonists, capsazepine and SB-366791, attenuated capsaicin-induced nociceptive reaction in a concentration-dependent manner. At 8 pg/20 pl, this effect was 51% （P〈0.001） for capsazepine and 37% （P〈0.05） for SB-366791. A TRPA1 antagonist, A-967079, reduced pain reaction by 48% （P〈0.05） in the AITC test and by 54% （P〈0.001） in the early phase of the formalin test. The test compounds had no influence on the late phase of the formalin test. In paclitaxel-treated mice, they did not attenuate heat hyperalgesia but N-（3-aminopropyl）-2-{[（3-methylphenyl）methyl]oxy}-N-（2-thienylmethyl） benzamide hydrochloride salt （AMTB）, a TRPM8 antagonist, reduced cold hyperalgesia and tactile allodynia by 31% （P〈0.05） and 51% （P〈0.01）, respectively. HC-030031, a TRPA1 channel antagonist, attenuated tactile allodynia in the von Frey test （62%; P〈0.001）. In conclusion, distinct members of TRP channel family are involved in different pain models in mice. Antagonists of TRP channels attenuate nocifensive responses of neurogenic, tonic, and neuropathic pain, but their efficacies strongly depend on the pain model used.

关键词： Allyl isothiocyanate Capsaicin Formalin Neurogenic pain Transient receptor potential channels,Paclitaxel-induced sensory neuropathy

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Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

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World Journal of Gastroenterology 2019年第34期25卷 5026-5048页

作者： Orsolya Galamb barbara k barták Alexandra kalmár Zsófia B Nagy krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár Molecular Medicine Research Group Hungarian Academy of SciencesBudapest H-1088Hungary 2nd Department of Internal Medicine Semmelweis UniversityBudapest H-1088Hungary

Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 *** participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is *** are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic *** addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic *** review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC ***,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC.

关键词： Long non-coding RNA Colorectal cancer Colorectal adenoma Circulating long non-coding RNAs Exosome Biomarker Diagnostic marker Prognostic marker

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Changes in the gut mycobiome in pediatric patients in relation to the clinical activity of Crohn's disease

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World Journal of Gastroenterology 2023年第14期29卷 2172-2187页

作者： Agnieszka krawczyk Dominika Salamon kinga kowalska-Duplaga barbara Zapała Teofila książek Marta Drażniuk-Warchoł Tomasz Gosiewski Department of Microbiology Division of Molecular Medical MicrobiologyJagiellonian University Medical CollegeCracow 31-121Poland Department of Pediatrics Gastroenterology and NutritionJagiellonian University Medical CollegeCracow 30-663Poland Department of Clinical Biochemistry Jagiellonian University Medical CollegeCracow 31-066Poland Department of Medical Genetics Jagiellonian University Medical CollegeCracow 30-663Poland Department of Pediatrics Gastroenterology and NutritionUniversity Children's HospitalCracow 30-663Poland

BACkGROUND Numerous studies have shown that in Crohn’s disease(CD),the gut microbiota is of great importance in the induction and maintenance of inflammation in the gastrointestinal *** recently,studies have focused almost exclusively on bacteria in the ***,more attention has been paid to the role of intestinal *** To study the gut mycobiome analysis of pediatric patients with CD(in different stages of disease activity)compared to healthy *** Fecal samples were collected from patients:With active,newly diagnosed CD(n=50);active but previously diagnosed and treated CD(n=16);non-active CD and who were in clinical remission(n=39)and from healthy volunteers(n=40).Fungal DNA was isolated from the ***,next generation sequencing(MiSeq,Illumina)was *** composition of mycobiota was correlated with clinical and blood *** Candida *** overrepresented in CD patients,while in the control group,the most abundant genus was *** CD patients,the percentage of Malassezia was almost twice that of the control(P<0.05).In active CD patients,we documented a higher abundance of Debaryomyces hansenii(***)compared to the non-active CD and control(P<0.05)***,statistically significant changes in the abundance of Mycosphaerella,Rhodotorula,and Microidium were *** analyses at the species level and linear discriminant analysis showed that in each group it was possible to distinguish a specific species characteristic of a given patient ***,we have documented statistically significant correlations between:*** and patient age(negative);*** and patient age(positive);*** and calprotectin(positive);*** and calprotectin(positive);and *** and pediatric CD activity index(PCDAI)(positive).CONCLUSION Mycobiome changes in CD patients,and the positive correlation of some species with calprotectin or PCDAI,give strong evidence that fungi may be

关键词： Intestinal mycobiome Fungi Crohn’s disease Inflammatory bowel disease Next generation sequencing Molecular microbiology

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PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

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Bioactive Materials 2021年第6期6卷 1811-1826页

作者： Michal Dziadek kinga Dziadek kamila Checinska barbara Zagrajczuk Monika Golda-Cepa Monika Brzychczy-Wloch Elzbieta Menaszek Aneta kopec katarzyna Cholewa-kowalska Jagiellonian University Faculty of Chemistry2 Gronostajowa St.30-387KrakowPoland AGH University of Science and Technology Faculty of Materials Science and CeramicsDepartment of Glass Technology and Amorphous Coatings30 Mickiewicza Ave.30-059KrakowPoland University of Agriculture in krakow Faculty of Food TechnologyDepartment of Human Nutrition and Dietetics122 Balicka St.30-149KrakowPoland Jagiellonian University Medical CollegeDepartment of Molecular Medical Microbiology18 Czysta St.31-121KrakowPoland Jagiellonian University Medical CollegeDepartment of Cytobiology9 Medyczna St.30-688KrakowPoland

In this work,polymeric and bioactive glass(BG)-modified composite films were successfully loaded with polyphenols(PPh)extracted from *** was hypothesized that PPh,alone and in combination with BGs particles,would affect physicochemical and biological properties of the ***,sol-gel-derived BG particles would serve as an agent for control the release of the polyphenolic compounds,and other important properties related to the presence of *** results showed that polyphenolic compounds significantly modified numerous material properties and also acted as biologically active *** the one hand,PPh can be considered as plasticizers for PCL,on the other hand,they can act as coupling agent in composite materials,improving their mechanical *** presence of PPh in materials improved their hydrophilicity and apatite-forming ability,and also provided antioxidant *** is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh,and by the modification of PCL matrix with sol-gel-derived BG particles,capable of binding *** films containing the lowest concentration of PPh exhibited cytocompatibility,significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins(osteocalcin and osteopontin)in human normal osteoblasts,while they reduced intracellular reactive oxygen species production in ***,materials loaded with PPh showed antibiofilm properties against Gram positive and Gram negative *** results suggest that obtained materials represent potential multifunctional biomaterials for bone tissue engineering with a wide range of tunable properties.

关键词： Tissue engineering Drug delivery Antioxidant properties Plant extract

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食用菌与人类健康(三)

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食药用菌 2015年第4期23卷 225-230页

8 消费者喜好与食用菌感官性状2011年，美国人均消费1．8千克食用菌，其中鲜菇为1．3千克。一项对12618名美国消费者进行的全国抽样调查结果显示，2012年，有41％的家庭购买过食用菌，至少消费5．53亿美元。其中，有三分之二的户主年龄... 详细信息

8 消费者喜好与食用菌感官性状2011年，美国人均消费1．8千克食用菌，其中鲜菇为1．3千克。一项对12618名美国消费者进行的全国抽样调查结果显示，2012年，有41％的家庭购买过食用菌，至少消费5．53亿美元。其中，有三分之二的户主年龄小于45岁，31％是有孩子的家庭，而59％是二人家庭；80％是白人，

关键词：食用菌人类健康消费者感官性状人均消费调查结果家庭美国

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食用菌与人类健康(二)

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食药用菌 2015年第3期23卷 185-187页

5食用菌对健康的影响和相关的生物标记许多临床前和临床实验表明,某些种类食用菌,不论是直接食用还是以提取物或其中的特定成分服用,均能降低患某些疾病的风险[18]。Roupas等[18]回顾了一系列影响健康的证据,所涉及的食用菌与认知能力... 详细信息

5食用菌对健康的影响和相关的生物标记许多临床前和临床实验表明,某些种类食用菌,不论是直接食用还是以提取物或其中的特定成分服用,均能降低患某些疾病的风险[18]。Roupas等[18]回顾了一系列影响健康的证据,所涉及的食用菌与认知能力、癌症、体重管理和口腔健康的关系部分,与本次峰会的介绍一致。5.1认知初步动物实验数据表明,

关键词：白色双孢蘑菇特定成分化醇缩氨酸直接食用临床前淀粉样提取物体重比树突状细胞

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食用菌与人类健康(一)

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食药用菌 2015年第2期23卷 82-85,101页

作者： Mary Jo Feeney Johanna Dwyer Clare M.Hasler-Lewis John A.Milner Manny Noakes Sylvia Rowe Mark Wach Robert B.Beelman Joe Caldwell Margherita T.Cantorna Lisa A.Castlebury Shu-Ting Chang Lawrence J.Cheskin Roger Clemens Greg Drescher Victor L.Fulgoni Ⅲ David B.Haytowitz Van S.Hubbard David Law Amy Myrdal Miller bart Minor Susan S.Percival Gabriela Riscuta barbara Schneeman Suzanne Thornsbury Cheryl D.Toner Catherine E.Woteki Dayong Wu 郑玲粮食和农业行业顾问洛斯拉图斯加利福尼亚州塔夫茨大学医学院和美国农业部人类老龄化营养研究中心波士顿马萨诸塞州罗伯特·蒙达维酒庄葡萄酒和食品科学研究所加州大学加利福尼亚州贝茨维尔人类营养研究中心美国农业部农业研究服务机构马里兰州澳大利亚联邦科学与工业研究组织阿德莱德澳大利亚 SR Strategy有限责任公司华盛顿特区 Sylvan股份有限公司基坦宁宾夕法尼亚州宾夕法尼亚州立大学食品科学系植物与食用茵产品健康中心宾夕法尼亚州蒙特利食用菌股份有限公司沃森维尔加利福尼亚州宾夕法尼亚州立大学兽医和生物医学科学系宾夕法尼亚州美国农业部农业研究服务机构系统真菌学和微生物实验室贝兹维尔马里兰州香港中文大学麦凯勒澳大利亚国会选区约翰霍普金斯大学彭博公共卫生学院约翰霍普金斯体重管理中心巴尔的摩马里兰州南加州大学药学院管理科学国际中心洛杉矶加利福尼亚州美国烹饪学院海德帕克纽约 Nutrition Impact有限责任公司巴特克里密歇根州美国农业部农业研究服务机构贝茨维尔人类营养研究中心营养数据实验室贝兹维尔马里兰州美国国立卫生研究院营养研究分院和国家糖尿病、消化和肾脏疾病研究所美国健康与人类服务部贝塞斯达马里兰州美味蘑菇股份有限公司塞瓦斯托波加利福尼亚州美国烹饪学院圣赫勒拿加利福尼亚州圣何塞蘑菇理事会加利福尼亚州佛罗里达大学食品科学与人类营养系盖恩斯维尔佛罗里达州美国国家癌症研究所癌症预防部营养科学研究小组美国国立卫生研究院罗克维尔马里兰加州大学戴维斯分校营养系戴维斯加利福尼亚州美国农业部经济研究服务机构市场经济和贸易部华盛顿特区 CDT咨询有限责任公司赫恩登弗吉尼亚州美国农业部研究、教育和经济机构华盛顿特区美国农业部让梅耶人类老龄化营养研究中心营养免疫学实验室和塔夫茨大学弗里德曼营养科学与政策学院波士顿马萨诸塞州《食药用菌》编辑部

2013年9月9~10日,美国蘑菇理事会在华盛顿召开食用菌与健康峰会。会议指出,将食用菌定位为健康食品和养生保健品的研究主要集中于最近的几十年。中国是最早栽培食用菌的国家,目前仍然和美国、意大利、荷兰、波兰一样,是全球食用菌生产... 详细信息

2013年9月9~10日,美国蘑菇理事会在华盛顿召开食用菌与健康峰会。会议指出,将食用菌定位为健康食品和养生保健品的研究主要集中于最近的几十年。中国是最早栽培食用菌的国家,目前仍然和美国、意大利、荷兰、波兰一样,是全球食用菌生产大国之一。虽然在饮食上,食用菌被认为是一种蔬菜,但它是一种真菌,区别在于食用菌中含量极低的维生素B12的存在形式与肉类的相同,麦角固醇能通过紫外光照转换为维生素D2和共轭亚油酸。食用菌是麦角硫因（存在于自然界的一种稀有氨基酸,在机体内具有重要的生理活性）的罕见来源,同时含有硒、纤维素及其他维生素和矿物质。一些临床前和临床试验,研究了食用菌对认知能力、体重管理、口腔健康和患癌几率的影响。初步证据表明,食用菌可能通过与肠道菌群的互动,提供良好的免疫和炎症反应,增强适应性免疫的发展和改进免疫细胞功能。除了直接提供营养和健康福祉之外,美国食物摄入量调查数据的分析表明,食用菌还与更高的膳食质量有关。早期的感官研究表明,食用菌与肉类和低钠菜肴混合很受欢迎,在不影响口味的情况下可能有助于减少红色肉类（牛、羊肉等）和盐的摄入。食用菌特定的健康效应研究进展表明,需要通过有效的沟通交流,实现利用食用菌来提高整体饮食质量的目标。.

关键词：食用菌人类健康峰会美国蘑菇理事会饮食质量

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2019年创新教学报告(下)

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当代职业教育 2019年第3期 104-112页

作者：丽贝卡·弗格森蒂姆·库夫兰凯蒂尔·埃格兰德斯代尔马克·盖德克里斯多西·西罗多加隆·希莱尔德里克·琼斯伊斯特林·乔尔斯艾格尼丝·库库斯卡·休姆帕特里克·麦克安德鲁卡米拉·米西尤克因贡·琼尼斯巴特·雷恩泰艾琳·斯坎伦麦克·沙普尔斯芭芭拉·沃森马丁·韦勒丹尼斯·怀特洛克贺伊丽(翻译) 王炜(编校) 英国开放大学教育技术研究所英国米尔顿凯恩斯MK76AA 挪威卑尔根大学学习科学与技术中心挪威卑尔根N-5020 不详

《2019年创新教学报告》发布于2019年1月,是英国开放大学于2012年开始发布的该系列年度报告的第7篇。该系列报告探讨了世界教学和评价的新形式,以指导教师和政策制定者进行富有成效的创新。《2019年创新教学报告》提出了10种教学法,分... 详细信息

《2019年创新教学报告》发布于2019年1月,是英国开放大学于2012年开始发布的该系列年度报告的第7篇。该系列报告探讨了世界教学和评价的新形式,以指导教师和政策制定者进行富有成效的创新。《2019年创新教学报告》提出了10种教学法,分别是趣味性学习、机器人辅助学习、去殖民化学习、基于无人机的学习、惊奇式学习、行动学习、虚拟工作室、基于地点的学习、思维可视化、同理心之根。这些教学方法已经开始流行,但尚未对教育产生深远影响。随着科技的发展,新技术和教学方法的结合越来越紧密,如何将技术浑然地融入教学,是值得认真思考的问题。

关键词：教学法趣味性学习机器人辅助学习去殖民化学习基于无人机的学习惊奇式学习行动学习虚拟工作室基于地点的学习思维可视化同理心之根

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