PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

作     者：Michal Dziadek Kinga Dziadek Kamila Checinska Barbara Zagrajczuk Monika Golda-Cepa Monika Brzychczy-Wloch Elzbieta Menaszek Aneta Kopec Katarzyna Cholewa-Kowalska 

作者机构：Jagiellonian UniversityFaculty of Chemistry2 Gronostajowa St.30-387KrakowPoland AGH University of Science and TechnologyFaculty of Materials Science and CeramicsDepartment of Glass Technology and Amorphous Coatings30 Mickiewicza Ave.30-059KrakowPoland University of Agriculture in KrakowFaculty of Food TechnologyDepartment of Human Nutrition and Dietetics122 Balicka St.30-149KrakowPoland Jagiellonian UniversityMedical CollegeDepartment of Molecular Medical Microbiology18 Czysta St.31-121KrakowPoland Jagiellonian UniversityMedical CollegeDepartment of Cytobiology9 Medyczna St.30-688KrakowPoland 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第6期

页      面：1811-1826页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the National Science Centre Poland Grant nos.2017/27/B/ST8/00195(KCK)and 2019/32/C/ST5/00386(MD) 

主　　题：Tissue engineering Drug delivery Antioxidant properties Plant extract 

摘      要：In this work,polymeric and bioactive glass(BG)-modified composite films were successfully loaded with polyphenols(PPh)extracted from *** was hypothesized that PPh,alone and in combination with BGs particles,would affect physicochemical and biological properties of the ***,sol-gel-derived BG particles would serve as an agent for control the release of the polyphenolic compounds,and other important properties related to the presence of *** results showed that polyphenolic compounds significantly modified numerous material properties and also acted as biologically active *** the one hand,PPh can be considered as plasticizers for PCL,on the other hand,they can act as coupling agent in composite materials,improving their mechanical *** presence of PPh in materials improved their hydrophilicity and apatite-forming ability,and also provided antioxidant *** is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh,and by the modification of PCL matrix with sol-gel-derived BG particles,capable of binding *** films containing the lowest concentration of PPh exhibited cytocompatibility,significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins(osteocalcin and osteopontin)in human normal osteoblasts,while they reduced intracellular reactive oxygen species production in ***,materials loaded with PPh showed antibiofilm properties against Gram positive and Gram negative *** results suggest that obtained materials represent potential multifunctional biomaterials for bone tissue engineering with a wide range of tunable properties.