Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors

作     者：Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár 

作者机构：Molecular Medicine Research GroupHungarian Academy of SciencesBudapest H-1088Hungary 2nd Department of Internal MedicineSemmelweis UniversityBudapest H-1088Hungary 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第34期

页      面：5026-5048页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the National Research Development and Innovation Office No.NVKP_16-1-2016-0004 

主　　题：Long non-coding RNA Colorectal cancer Colorectal adenoma Circulating long non-coding RNAs Exosome Biomarker Diagnostic marker Prognostic marker 

摘      要：Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 *** participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is *** are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic *** addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic *** review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC ***,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC.