Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

作     者：Sergiy Kostenko Gianina Dumitriu Kari Jenssen Lgreid Ugo Moens 

作者机构：Faculty of Health SciencesInstitute of Medical BiologyUniversity of TromsφNO-9037 TromsφNorway 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第5期

页      面：73-89页

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：Mitogen-activated protein kinase p38- regulated/activated protein kinase Extracellular signalregulated kinase Protein kinase A Subcellular localization Phosphorylation Protein interaction 

摘      要：Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and *** MAPK pathways can be divided into conventional and atypical MAPK *** first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and *** MAPK pathways are not organized into this three-tiered *** that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein *** latter are referred to as MAPK-activated protein *** review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK *** findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed.