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Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

World Journal of Biological Chemistry 2011年第5期2卷 73-89页

作者： Sergiy Kostenko Gianina Dumitriu Kari Jenssen Lgreid Ugo Moens Faculty of Health Sciences Institute of Medical BiologyUniversity of TromsφNO-9037 TromsφNorway

Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and *** MAPK pathways can be divided into conventional and atypical MAPK *** first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and *** MAPK pathways are not organized into this three-tiered *** that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein *** latter are referred to as MAPK-activated protein *** review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK *** findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed.

关键词： Mitogen-activated protein kinase p38- regulated/activated protein kinase Extracellular signalregulated kinase Protein kinase A Subcellular localization Phosphorylation Protein interaction

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