Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats
Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats作者机构：Department of PharmacologyFaculty of Basic Medical SciencesCollege of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and TherapeuticsFaculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of Internal MedicineChukwuemeka Odumegwu Ojukwu University Teaching HospitalAwkaNigeria
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2018年第7卷第6期
页 面：274-279页
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 0901[农学-作物学] 100214[医学-肿瘤学] 0902[农学-园艺学] 10[医学]
主 题：Salacia lehmbachii Ovulation Estrous cycle Root bark Female sex hormones
摘 要：Objective:To evaluate the effect of Salacia lehmbachii (S. lehmbachii) ethanol root bark extract on estrous cycle and sex hormones in female rats. Methods: Forty-eight virgin rats with regular 4-day cycle were grouped into four and each group was further subdivided into a and b (n=6). Each group was orally treated for 28 days with 2 mL of distilled water (control), ethanol root bark extract ofS. lehmbachii in doses of 250, 500 and 750 mg/kg/body weight (groups 2, 3, 4, respectively). Estrous cycle was determined daily using the vaginal smear method. Rats in a subgroups were weighed and sacrificed on the 29th day, and blood was collected for serum generation which was used for hormonal assay and sex organs were removed and weighed. Rats in b subgroups were discontinued from treatment for 2 weeks and the parameters above were ***:The mean length of estrous cycle and duration of diestrous of treated rats were prolonged dose dependently compared to control. The increase was significant (P0.05) at 500 and 750 mg/kg. The other estrous phases were shortened in the same pattern. Relative weights of sex organs were reduced significantly (P0.05) at the highest dose. Sex hormones levels were significantly (P0.05) reduced compared to control. The above changes reverted towards the control values two weeks post ***: Ethanol root bark extract ofS. lehmbachii (high doses) has antifertility effect in female rats as it prolongs the estrous and diestrous cycle, and reduces serum sex hormones levels. The observed alterations were reversible.
维普期刊数据库