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Effects of salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats

Asian pacific Journal of Reproduction 2018年第6期7卷 274-279页

作者： Grace A.Essiet Godwin C.Akuodor Daniel OJ Aja Mathew O.Nwokike Desmond O.Eke Anuli N.Chukwumobi Department of Pharmacology Faculty of Basic Medical SciencesCollege of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and Therapeutics Faculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of Internal Medicine Chukwuemeka Odumegwu Ojukwu University Teaching HospitalAwkaNigeria

Objective:To evaluate the effect of salacia lehmbachii (S. lehmbachii) ethanol root bark extract on estrous cycle and sex hormones in female rats. Methods: Forty-eight virgin rats with regular 4-day cycle were grouped into four and each group was further subdivided into 'a' and 'b' (n=6). Each group was orally treated for 28 days with 2 mL of distilled water (control), ethanol root bark extract ofS. lehmbachii in doses of 250, 500 and 750 mg/kg/body weight (groups 2, 3, 4, respectively). Estrous cycle was determined daily using the vaginal smear method. Rats in'a' subgroups were weighed and sacrificed on the 29th day, and blood was collected for serum generation which was used for hormonal assay and sex organs were removed and weighed. Rats in 'b' subgroups were discontinued from treatment for 2 weeks and the parameters above were ***:The mean length of estrous cycle and duration of diestrous of treated rats were prolonged dose dependently compared to control. The increase was significant (P<0.05) at 500 and 750 mg/kg. The other estrous phases were shortened in the same pattern. Relative weights of sex organs were reduced significantly (P<0.05) at the highest dose. Sex hormones levels were significantly (P<0.05) reduced compared to control. The above changes reverted towards the control values two weeks post ***: Ethanol root bark extract ofS. lehmbachii (high doses) has antifertility effect in female rats as it prolongs the estrous and diestrous cycle, and reduces serum sex hormones levels. The observed alterations were reversible.

关键词： salacia lehmbachii Ovulation Estrous cycle Root bark Female sex hormones

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Antiplasmodial,cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from salacia leptoclada Tul.(Celastraceae)originated from Madagascar

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 780-784页

作者： Fatiany Pierre Ruphin Robijaona Baholy Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187.University of Toliara601 Toliara Madagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.O.BOX 3833102 Antananarivo Madagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centre for Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.O.BOX 190 Kinshasa XIDemocratic.Republic of the Congo

Objective:To validate scientifically the traditional use of salacia leptoclada Tul.(Celastraceae)(***)and to isolate and elucidate the structure of the biologically active ***:Bioassay-guided fractionation of the acetonic extract of the stem barks of *** was carried out by a combination of chromatography technique and biological experiments in viro using Plasmodium falciparum and P388 leukemia cell lines as *** structure of the biologically active pure compound was elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological screening of *** extracts resulted in the isolation of a pentacyclic triterpenic quinone *** pure compound exhibited both in vitro a cytotoxic effect on murine P388 leukemia cells with IC_(50)value of(0.041±0.020)μg/mL and an antiplasmodial activity against the chloroquine-resistant strain FC29 of Plasmodium falciparum with an IC_(50)value of(0.052±0.030)μg/*** this interesting anti-malarial property of the lead compound,the therapeutic index was weak(0.788).In the best of our knowledge,the quinone methide pentacyclic triterpenoid derivative compound is reported for the first time in ***:The results suggest that furthers studies involving antineoplastic activity is needed for the development of this lead compound as anticancer drug.

关键词： salacia leptoclada Quinone methide Malaria Therapeutic index Cancer Madagascar

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