慢性腰背痛患者的P50潜伏中期听觉诱发电位

作     者：Fann A.V. Preston M.A. Bray P. 江山 

作者机构：Dept.of Phys. Med. and Rehab . Ctrl. Arkansas Vet. Hlthcare.System 2200 Fort Roots Dr North Little Rock A R72114 United States 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第7期

页      面：16-17页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：慢性腰背痛 P50 听觉诱发电位 抗抑郁治疗 auditory sensory 郁症 evoked deficit medication 

摘      要：Objective: Patients with Chronic Low Back Pain (CLBP) show arousal, attentiona l and cognitive disturbances. The sleep state dependent P50 midlatency auditory evoked potential was used to determine if patients with CLBP [with and without c o-morbid depression (DEP)] show quantitative disturbances in the manifestation of the P50 potential. Methods: P50 potential latency,amplitude and habituation t o repetitive stimuli at 250,500and 1000 ms interstimulus intervals (ISIs) was re corded, along with the McGill Pain Questionnaire-Short Form (MPQ-SF).CLBP subj ects (n=42) were compared with Controls (n=43), and with subjects with DEP only (n=6). Of the CLBP subjects, 20/42 had clinical depression (CLBP+DEP); 8/20 wer e taking anti-depressant medication (CLBP+DEP+med), the others were not (CLBP +DEP-med). Results: There were no differences (ANOVA) in age, sex or P50 poten tial latency, although there was a trend towards increased latencies in CLBP gro ups. P50 potential amplitude was lower in CLBP groups, but not in sub-groups, a gain indicating a trend. P50 potential habituation was decreased in the DEP only subjects at the 250 m ISI, and decreased in CLBP+DEPmed subjects at the 500 ms ISI. This difference was not present in CLBP+DEP+med subjects. The MPQ-SF re vealed that patients with CLBP and CLBP+DEP-med showed lower pain scores than CLBP+DEP+med patients. Conclusions: There is decreased habituation of the P50 potential habituation in unmedicated patients with CLBP+DEP compared to C ***: Patients with CLBP+DEP-med may be less able to disregard incoming sensory information, including painful sensations, but anti-depressan t medications help correct this deficit. However, their perception of pain may b e increased by medication.