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Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.Kong Jingying Zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several diseases.Here,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold condition.All major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown remodeling.Our findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to cold.The adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is potentiated.Furthermore,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)adipocyte.Beige adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to cold.Our data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

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Transcriptomic and Macroscopic Architectures of Multimodal Covariance Network Reveal Molecular–Structural–Functional Co-alterations

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Research 2024年第1期2023卷 471-487页

作者： Lin Jiang Yueheng Peng Runyang He Qingqing Yang Chanlin Yi Yuqin Li Bin Zhu Yajing Si Tao Zhang Bharat B.Biswal Dezhong Yao Lan Xiong Fali Li Peng Xu The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Life Science and Technology Center for Information in BioMedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Psychology Xinxiang Medical UniversityXinxiang 453003China School of Science Xihua UniversityChengdu 610039China Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJUSA School of Electrical Engineering Zhengzhou UniversityZhengzhou 450001China Research Unit of NeuroInformation Chinese Academy of Medical Sciences2019RU035ChengduChina Montreal Neurological Institute and Hospital McGill UniversityMontrealQCCanada Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Radiation Oncology Key Laboratory of Sichuan Province 610041 ChengduChina Rehabilitation Center Qilu Hospital of Shandong UniversityJinan 250012China

Human cognition is usually underpinned by intrinsic structure and functional neural co-activation in spatially distributed brain regions.Owing to lacking an effective approach to quantifying the covarying of structure and functional responses,how the structural–functional circuits interact and how genes encode the relationships,to deepen our knowledge of human cognition and disease,are still unclear.Here,we propose a multimodal covariance network(MCN)construction approach to capture interregional covarying of the structural skeleton and transient functional activities for a single individual.We further explored the potential association between brain-wide gene expression patterns and structural–functional covarying in individuals involved in a gambling task and individuals with major depression disorder(MDD),adopting multimodal data from a publicly available human brain transcriptomic atlas and 2 independent *** analysis showed a replicable cortical structural–functional fine map in healthy individuals,and the expression of cognition-and disease phenotype-related genes was found to be spatially correlated with the corresponding MCN differences.Further analysis of cell type-specific signature genes suggests that the excitatory and inhibitory neuron transcriptomic changes could account for most of the observed correlation with task-evoked MCN differences.

关键词： alterations evoked spatially

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SeHed,a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2698-2700页

作者： Ning Huang Honghan Chen Hui Gong Haoran Tai Xiaojuan Han Xiaobo Wang Chuhui Gong Tingting Zhao Yu Yang Hengyi Xiao The Lab for Aging Research National Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China HospitalSichuan University1 Keyuan 4 RoadGaopeng AvenueChengdu 610041China Development and Regeneration Key Lab of Sichuan Province Department of Anatomy and Histology and EmbryologyChengdu Medical CollegeChengduChina Shaanxi Key Laboratory of Brain Disorders and Institute of Basic and Translational Medicine Xi’an Medical UniversityXi’an 710049China School of Basic Medicine Dali UniversityDaliYunnan 671000China

Dear Editor,The moderate level of reactive oxygen species(ROS)contributes to cellular functions such as proliferation,differentiation,and infection resistance,but the excessive level of ROS causes oxidative damage which underlies the basic mechanism for aging and geriatric diseases.1 Therefore,precisely managing cellular ROS levels,meaning to keep redox homeostasis properly,stands as an aim for health and longevity.Actually,this aim is challenging,as it asks not only to restrain excessive ROS accumulation at the right time and right place but also to guarantee proper ROS levels for fitting physiological requirements.Traditional ways for eliminating ROS put more attention on the efficiency and identified a variety of drugs and enzymes with antioxidant properties,known as enzymatic and non-enzymatic ROS scavengers,respectively.However,how to accurately manage the integrative effect of ROS scavengers in vivo remains a problem.Actually,the effectiveness of non-enzymatic antioxidants in vivo is controversial,explained mostly by the uncertainty to reach a given organ with the appropriate concentration or to work there persistently.2 As to enzymatic ROS scavengers,although their overexpression in a given place can be achieved,this mode is often unwieldy or harmful to intrinsic physiologic functions in cases.3 For this reason,we attempt to develop new ways for in vivo antioxidation,for establishing a high-quality balance between efficiency and safety.As the consequence,we innovated a gene expression system that can limit the excessive ROS accumulation but keep the physiological level of ROS.

关键词： evoked aging effect

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Effect of digit ratio on contact heat evoked potentials in China

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Chinese Medical Journal 2022年第4期135卷 480-481页

作者： Bo Sun Hongfen Wang Zhengqing He Xusheng Huang Zhaohui Chen Fei Yang Department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Geriatric Neurology The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China

To the Editor:Contact heat evoked potentials(CHEPs)has become an important electrophysiologic diagnostic approach for small fiber neuropathy,[1]which is characterized by involvement of myelinated Aδand unmyelinated C fibers as a result of various etiologies.[1,2]CHEPs are affected by gender,age,body height,and so on.[1,2]The effect of the second to fourth(2D:4D)digit ratio on CHEP parameters has not been investigated.Digit ratio is defined as the length of the index finger dividing the length of the ring finger,which is smaller in men than in women.[3]We aimed to find out whether digit ratio has any role influencing CHEPs,and to strengthen the understanding and improve the methodology of CHEPs.

关键词： evoked involvement digit

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The potential utility of evoked potentials in thetreatment of mental illnesses

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Psychoradiology 2023年第1期3卷 33-35页

作者： Salvatore Campanella Labor atoir e de Psychologie Médicale et d’Addictologie ULB Neuroscience Institute(UNI)CHU Brugmann-UniversitéLibre de Bruxelles(U.L.B.)1020 BrusselsBelgium

The“Decade of the Brain”referred to the 1990s,as the emergence of various brain imaging techniques allo w ed the analysis of both normal and pathological behaviors with specific patterns of distributed neural activi... 详细信息

关键词： evoked treatment potential

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Cortical and spinal evoked potential response to electrical stimulation in human rectum

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World Journal of Gastroenterology 2010年第43期16卷 5440-5446页

作者： Brian Garvin Lisa Lovely Alex Tsodikov Danielle Minecan Shaungson Hong John W Wiley Department of Internal Medicine University of Michigan Michigan Clinical Research Unit Level 1 Room 1702 Cardiovascular Center 1500E Medical Center Drive Ann Arbor MI 48109 United States Department of Neurology University of Michigan Ann Arbor MI 48109 United States Department of Biostatistics University of Michigan Ann Arbor MI 48109 United States

AIM: To study a novel technique to record spinal and cortical evoked potentials (EPs) simultaneously in response to electrical stimulation in the human rectum. METHODS: Eight male and nine female healthy volunteers participated. Stimulating electrodes were attached to the rectal mucosa at 15 cm and 12 cm above the dentate line. Recording skin electrodes were positioned over vertebrae L4 through S2. The electrical stimulus was a square wave of 0.2 ms duration and the intensity of the stimulus varied between 0 and 100 mA. EP responses were recorded using a Nicolet Viking IV programmable signal conditioner.RESULTS: Simultaneous recording of cortical and spinal EPs was obtained in > 80% of the trials. The EP responses increased with the intensity of the electrical stimulation, were reproducible overtime, and were blocked by application of Lidocaine jelly at the site of stimulation. The morphology (N1/P1), mean ± SD for latency (spinal N1, 4.6 ± 0.4 ms; P1, 6.8 ± 0.5 ms; cortical N1, 136.1 ± 4.2 ms; P1, 233.6 ± 12.8 ms) and amplitude (N1/P1, spinal, 38 ± 7 μV; cortical 19 ± 3 μV) data for the EP responses were consistent with those in the published literature. Reliable and reproducible EP recordings were obtained with the attachment of the electrodes to the rectal mucosa at predetermined locations between 16 and 8 cm above the anal verge, and the distance between the attachment sites of the electrodes (the optimal distance being approximately 3.0 cm between the two electrodes). CONCLUSION: This technique can be used to assess potential abnormalities in primary afferent neural pathways innervating the rectum in several neurodegenerative and functional pain disorders.

关键词： Spinal evoked potentials Cortical evoked potentials Rectum Electrical stimulation Primary afferent neurons Visceral sensation

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Contact heat evoked potentials in knowledge workers and unskilled labors

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Chinese Medical Journal 2020年第5期133卷 537-541页

作者： Bo Sun Yan-Ran Li Hong-Fen Wang Fang Cui Li Ling Fei Yang Zhao-Hui Chen Xu-Sheng Huang Geriatric Neurological Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China Neurological Department of the First Medical Center Chinese People’s Liberation Army General HospitalBeijing 100853China

Background:Whether occupation has an impact on contact heat evoked potential(CHEP)results has not been investigated.In this study,we investigated the difference of CHEP parameters between knowledge workers and unskilled labors.Methods:A total of 137 healthy participants were recruited between November 20,2014 and December 31,2016.All participants underwent neurologic examination,laboratory examination,and nerve conduction studies.CHEP was performed on four body sites:the upper border of the distal third of the volar forearm,the upper border of the distal third of the lateral leg,the spinous process of seventh cervical vertebrae(C7),and the spinous process of 12th thoracic vertebrae(T12).Independent t test and nonparametric test were performed using SPSS software to compare the difference of the CHEP parameters between knowledge workers and unskilled labors.Results:The“N2 latency/height”(Z=-2.290,P=0.022)and“P2 latency/height”(Z=-2.020,P=0.043)on the volar forearm of unskilled labors significantly increased than those of knowledge workers.The“N2 latency/height”(F=6.348,P=0.016)and“P2 latency/height”(F=5.920,P=0.018)in the distal leg of unskilled labors significantly prolonged than those of knowledge workers.The N2-P2 amplitude(F=5.797,P=0.020)in the distal leg of unskilled labors significantly decreased than those of knowledge workers.Conclusions:Our study found that significantly prolonged N2 latency and P2 latency and significantly decreased N2-P2 amplitude in the distal leg and the volar forearm in unskilled labors as to knowledge workers.

关键词： Contact heat evoked potential Occupation Nerve conduction studies

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Ipsilateral motor evoked potentials in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis

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Neural Regeneration Research 2019年第6期14卷 1025-1028页

作者： Raffaele Nardone Patrick B.Langthaler Andrea Orioli Viviana Versace Giuditta Ilaria Scarano Francesco Brigo Leopold Saltuari Luca Carnicelli Eugen Trinka Luca Sebastianelli Department of Neurology Franz Tappeiner HospitalMeranoItaly Department of Neurology Hochzirl HospitalZirlAustria Centre for Cognitive Neurosciences Salzburg SalzburgAustria University for Medical Informatics and Health Technology UMITHall in TirolAustria Department of Neurology Christian Doppler KlinikParacelsus Medical UniversitySalzburgAustria Spinal Cord Injury and Tissue Regeneration Center SalzburgAustria Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie SalzburgAustria Department of Mathematics Paris Lodron University of SalzburgAustria Department of Neurorehabilitation Hospital of VipitenoVipitenoItaly Research Unit for Neurorehabilitation South Tyrol BolzanoItaly Department of Psychology Franz Tappeiner HospitalMeranoItaly Department of Neuroscience Biomedicine and Movement ScienceUniversity of VeronaVeronaItaly

The role of the ipsilaterally descending motor pathways in the recovery mechanisms after unilateral hemispheric damage is still poorly understood. Motor output reorganization was investigated in a 56-year-old male patient with acquired unilateral hemispheric atrophy due to Rasmussen encephalitis. In particular,the ipsilateral corticospinal pathways were explored using focal transcranial magnetic stimulation. In the first dorsal interosseous and wrist extensors muscles, the median amplitudes of the ipsilateral motor evoked potentials induced by transcranial magnetic stimulation in the patient were higher than those of 10 age-matched healthy control subjects. In the biceps brachii muscle, the median amplitudes of the ipsilateral motor evoked potentials were the second largest in the patient compared to the controls. This study demonstrated a reinforcement of ipsilateral motor projections from the unaffected motor cortex to the hemiparetic hand in a subject with acquired unihemispheric cortical damage.

关键词： transcranial magnetic stimulation motor cortex ipsilateral motor evoked potentials ipsilateral motor pathways Rasmussen encephalitis cortical atrophy hemispheric damage

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Vestibular evoked myogenic potentials in patients with diabetes mellitus

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Journal of Otology 2019年第3期14卷 89-93页

作者： Ali Bayram Department of ENT Kayseri City Hospital Seker Mah.Molu Village

Although the exact mechanism and most involved region of the vestibular system have not yet been fully clarified, vestibular dysfunction has been demonstrated in patients with diabetes mellitus (DM). Vestibular evoked myogenic potential (VEMP) is a short latency electromyographic response to sound or vibration stimuli that may reflect otolith organ or related reflex functions. Since its first description in 1992, VEMP has become a significant part of the vestibular test battery as an objective measurement tool. In diabetic patients, VEMP responses have been studied in order to determine any otolith organ or related reflex dysfunctions. Here, we review the literature with regard to VEMP findings representing any peripheral vestibular end-organ dysfunction in patients with DM. Distinctive vestibular end-organ impairments seem to be demonstrated in patients with DM either with or without DNP via objective vestibular testing tools including VEMP recordings according to relevant studies. However, further studies with larger sample sizes are required to reveal the more definitive findings of VEMP recordings regarding the vestibular pathologies in patients with DM.

关键词： Diabetes mellitus Vestibular diseases Cervical vestibular evoked myogenic potentials Ocular vestibular evoked myogenic potentials

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Local Electroretinogram and Pattern Visual evoked Potential in Maculopathies

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Eye Science 1996年第1期16卷 40-45页

作者： De-zheng Wu, Guangwei Luo, Yi HuangZhongshan Ophtalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510050, China Department of Ophthalmology, Xiang Fan Centre Hospital, Hubei 441021, China Zhongshan Ophtalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

Purposes: To observe the characteristics of local electroretinogram (LERG) in normal subjects and patients with maculopathies, and to evaluate the applied worth of LERG and pattern visual evoked potential (PVEP) in maculopathies. Methods: LERGs at 5° and 15° macular regions were recorded from 27 normal subjects (54 eyes). The factors of age, different eyes and stimulate areas for LERG influence were observed. Meanwhile, the LERG and PVEP were recorded from 25 patients (35 eyes) with maculopathies for making contrast study. Results: In normal subjects, there was no significant influence of age to LERG. As the stimulated areas increased, the a- and b-wave amplitudes of LERG increased. In the patients with maculopathies, the a- and b-wave amplitudes of LERG at 5°, 10°and 15° macular regions were significantly lowered and the mean values of P1 latency were prolonged and N1-P1 amplitudes of VEP were lowered, comparing with the control group. In the nearing stimulated area (5°LERG and 14. 9×19°PVEP.),

关键词： maculopathy local electroretinogram (LERG) pattern visual evoked potential (PVEP)

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