Sleep,immunity and inflammation in gastrointestinal disorders
Sleep,immunity and inflammation in gastrointestinal disorders作者机构：Inflammatory Bowel Disease Center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Department of Medicine University of Oklahoma Health Science Center Oklahoma City OK 73104 United States Department of Medicine Section of Pulmonary and Critical Care Oklahoma City OK 73104 United States Department of Pediatrics University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States Lynn Health Science Institute Oklahoma City OK 73112 United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第48期
页 面：9231-9239页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Sleep Immune function Immunity Irritable bowel syndrome Inflammatory bowel disease Gastroesophageal reflux disease Liver disorders Colon cancer Circadian rhythm
摘 要：Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research *** estimated 70 million Americans suffer from some form of sleep *** sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance *** research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause *** research studies support the associations among sleep,immune function and ***,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal *** physiologic processes including immune system and inflammatory cytokines help regulate the *** inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep *** the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory *** in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal *** turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal *** of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients.
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