Effect of awareness,quarantine and vaccination as control strategies on COVID-19 with Co-morbidity and Re-infection

作     者：Amit Kumar Saha Shikha Saha Chandra Nath Podder 

作者机构：Department of MathematicsUniversity of DhakaDhaka1000Bangladesh Department of MathematicsBangladesh University of Engineering and Technology(BUET)Dhaka1000Bangladesh 

出 版 物：《Infectious Disease Modelling》 (传染病建模（英文）)

年 卷 期：2022年第7卷第4期

页      面：660-689页

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：COVID-19 Co-morbidity Face-mask Quarantine Vaccination Optimal control Re-infection 

摘      要：In this paper,a deterministic compartmental model is presented to assess the impact of vaccination and non-pharmaceutical interventions(social distance,awareness,face mask,and quarantine)on the transmission dynamics of COVID-19 with co-morbidity and reinfection.An expression for the basic reproduction number is then derived for this model.Theoretical analysis shows that the model exhibits backward bifurcation phenomenon when the basic reproduction number is less than unity.But for the case of no reinfection,the model has a globally asymptotically stable disease-free equilibrium(DFE)when the basic reproduction number is less than unity.Furthermore,it is shown that in the case of no re-infection,a unique endemic equilibrium point(EEP)of the model exists which is globally asymptotically stable whenever the reproduction number is greater than unity.From the global sensitivity and uncertainty analysis,we have identified mask coverage,mask efficacy,vaccine coverage,vaccine efficacy,and contact rate as the most influential parameters influencing the spread of COVID-19.Numerical simulation results show that the use of effective vaccines with proper implementation of non-pharmaceutical interventions could lead to the elimination of COVID-19 from the community.Numerical simulations also suggest that the control strategy that ensures a continuous and effective mass vaccination program is the most cost-effective control strategy.The study also shows that in the presence of any co-morbidity and with the occurrence of re-infection,the disease burden may increase.