Effect of awareness,quarantine and vaccination as control strategies on COVID-19 with Co-morbidity and Re-infection

作     者：Amit Kumar Saha Shikha Saha Chandra Nath Podder 

作者机构：Department of MathematicsUniversity of DhakaDhaka1000Bangladesh Department of MathematicsBangladesh University of Engineering and Technology(BUET)Dhaka1000Bangladesh 

出 版 物：《Infectious Disease Modelling》 (传染病建模（英文）)

年 卷 期：2022年第7卷第4期

页      面：660-689页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：COVID-19 Co-morbidity Face-mask Quarantine Vaccination Optimal control Re-infection 

摘      要：In this paper,a deterministic compartmental model is presented to assess the impact of vaccination and non-pharmaceutical interventions(social distance,awareness,face mask,and quarantine)on the transmission dynamics of COVID-19 with co-morbidity and *** expression for the basic reproduction number is then derived for this *** analysis shows that the model exhibits backward bifurcation phenomenon when the basic reproduction number is less than *** for the case of no reinfection,the model has a globally asymptotically stable disease-free equilibrium(DFE)when the basic reproduction number is less than ***,it is shown that in the case of no re-infection,a unique endemic equilibrium point(EEP)of the model exists which is globally asymptotically stable whenever the reproduction number is greater than *** the global sensitivity and uncertainty analysis,we have identified mask coverage,mask efficacy,vaccine coverage,vaccine efficacy,and contact rate as the most influential parameters influencing the spread of *** simulation results show that the use of effective vaccines with proper implementation of non-pharmaceutical interventions could lead to the elimination of COVID-19 from the *** simulations also suggest that the control strategy that ensures a continuous and effective mass vaccination program is the most cost-effective control *** study also shows that in the presence of any co-morbidity and with the occurrence of re-infection,the disease burden may increase.