中国结直肠肿瘤经自然腔道取标本手术患者短期疗效与肿瘤学预后分析:一项5055例患者的数据库研究

作     者：关旭 胡茜玥 姜争 韦烨 孙东辉 吴淼 周海涛 姚宏亮 宋军民 王贵玉 胡军红 任明扬 徐庆 蔡建春 彭健 马丹 郑阳春 何庆泗 江波 王泽军 李太原 燕速 陈路川 李铁钢 熊治国 池畔 康亮 于刚 邓小东 张宏 谢铭 韦建宝 宫红彦 孙学军 臧卫东 宋永茂 赫鹏 文政琦 张春旭 王昱晟 陈瑛罡 谢光伟 李明章 俞少俊 刘海鹰 蒲敏 傅传刚 王锡山 中国经自然腔道取标本手术联盟 Xu Guan;Xiyue Hu;Zheng Jiang;Ye Wei;Donghui Sun;Miao Wu;Haitao Zhou;Hongliang Yao;Junmin Song;Guiyu Wang;Junhong Hu;Mingyang Ren;Qing Xu;Jianchun Cai;Jian Peng;Dan Ma;Yangchun Zheng;Qingsi He;Bo Jiang;Zejun Wang;Taiyuan Li;Su Yan;Luchuan Chen;Tiegang Li;Zhiguo Xiong;Pan Chi;Liang Kang;Gang Yu;Xiaodong Deng;Hong Zhang;Ming Xie;Jianbao Wei;Hongyan Gong;Xuejun Sun;Weidong Zang;Yongmao Song;Peng He;Zhengqi Wen;Chunxu Zhang;Yusheng Wang;Yinggang Chen;Guangwei Xie;Mingzhang Li;Shaojun Yu;Haiying Liu;Min Pu;Chuangang Fu;Xishan Wang;on behalf of China NOSES Alliance

作者机构：Department of Colorectal SurgeryNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General SurgeryZhongshan HospitalFudan UniversityShanghai 200032China Department of Gastrointestinal and Anal SurgeryJilin University First HospitalChangchun 130021China Department of Gastrointestinal SurgeryThe Second People’s Hospital of YibinYibin 644000China Department of Gastrointestinal SurgeryThe Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Anorectal SurgeryFirst Affiliated HospitalZhengzhou UniversityZhengzhou 450052China Department of Colorectal Cancer SurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal SurgeryAffiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Gastrointestinal SurgeryRenji HospitalShanghai JiaoTong University School of MedicineShanghai 200240China Department of Gastrointestinal SurgeryZhongshan Hospital of Xiamen UniversityXiamen 361004China Department of General SurgeryXiangya HospitalCentral South UniversityChangsha 410008China Department of General SurgeryXinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Gastrointestinal SurgerySichuan Cancer HospitalChengdu 610041China Department of General SurgeryShandong University Qilu HospitalJinan 250012China Department of Colorectal and Anal SurgeryShanxi Cancer HospitalTaiyuan 030013China Department of Gastrointestinal SurgeryThe Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550008China Department of General SurgeryThe First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Gastrointestinal SurgeryQinghai University Affiliated HospitalXining 810012China Department of Gastrointestinal SurgeryFujian Medical University Cancer HospitalFuzhou 350014China Department of Gastrointestinal SurgeryHubei Provincial Cancer HospitalWuhan 430079China Department of Colorectal SurgeryUnion HospitalFujian Medical UniversityFuzhou 350001China Department of Colorectal SurgeryThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of General SurgeryQilu Hospital of Shandong University(Qingdao)Qingdao 266035China Department of Colorectal SurgeryShengjing Hospital of China Medical UniversityShenyang 110022China Department of Gastrointestinal SurgeryAffiliated Hospital of Zunyi Medical UniversityZunyi 563099China Department of Gastrointestinal SurgeryRuikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011China Department of Gastrointestinal SurgeryYantaishan HospitalYantai 264008China Department of General SurgeryFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710065China Department of Colorectal SurgeryThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Colorectal and Anal SurgeryThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100China Department of Surgical OncologyFirst Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of General SurgeryHospital No.988 of the Chinese People’s Liberation Army Joint Support ForceZhengzhou 450006China Department of General SurgeryJincheng People’s HospitalJincheng 048026China Department of Colorectal SurgeryNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China Department of Gastrointestinal SurgeryXuzhou Central HospitalXuzhou 221009China Department of General SurgeryBaotou Central HospitalBaotou 014042China Department of Gastrointestinal SurgeryAffiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Gastrointestinal and Hernia SurgeryAffiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Gastrointestinal SurgeryShanghai East HospitalTongji University School of MedicineShanghai 200120China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2022年第67卷第13期

页      面：1331-1334,M0003页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Beijing Municipal Science&Technology Commission(D171100002617004)。 

主　　题：结直肠肿瘤 肿瘤学 并发症发生率 无病生存率 吻合口瘘 回顾性研究 总生存率 经直肠 

摘      要：经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOSES患者数据,进一步探讨NOSES的短期疗效与预后.研究对象中,经直肠NOSES占整体比例的90.3%,经阴道NOSES占9.7%.NOSES术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOSES具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据.