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Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms:A bioinformatics study

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2150-2168页

作者： Wen-Jing Zhang Ke-Lin Yue Jing-Zhai Wang Yu Zhang Department of medical Oncology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina

BACKGROUND We previously demonstrated that heat shock factor protein 4(HSF4)facilitates colorectal cancer(CRC)*** methylation,a major modifier of gene expression and stability,is involved in CRC development and *** To investigate the correlation between HSF4 methylation and CRC risk,and to uncover the underlying molecular *** Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource ***4 methylation-related genes were identified by LinkedOmics in CRC,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE *** A total of 19 CpG methylation loci were identified in HSF4,and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA ***,the prognostic and diagnostic performance of these CpG loci in CRC patients was *** CRC,there were 1694 HSF4 methylation-related genes;1468 of which displayed positive and 226 negative associations,and they were involved in regulating phenotypes such as immune,inflammatory,and metabolic ***,RELA,STAT3,FCGR3A,POLR2K,and AXIN1 are hub genes among the HSF4 methylation-related *** HSF4 is highly methylated in CRC,but there is no significant correlation between it and the prognosis and diagnosis of ***4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.

关键词： Colorectal cancer DNA methylation Prognosis Diagnosis Bioinformatics Heat shock factor protein 4

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Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 525-534页

作者： Wei Zhao Le Dai Xiao-Ting Xi Qian-Bo Chen Mei-Xia An Yan Li Department of Ophthalmology the First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina Department of Ophthalmology the Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina

AIM: To investigate the relationships between the changes of heat shock protein 27 antibody(anti-HSP27) in serum/cerebrospinal fluid(CSF), intraocular pressure(IOP), retinal ganglion cell(RGC) apoptosis in a rat glaucoma model and disclose the underlying pathogenesis of ***: A total of 115 Wistar rats were randomly divided into 4 groups. Group 1 was the ocular hypertension group by condensing 3 episcleral & limbal veins or episcleral area of right eye(HP group, n=25) and sham operation group with conjunctiva incision without coagulation(n=25). Group 2: HSP27 or dose-matched PBS was injected into the vitreous(V-HSP27 group, n=15;V-PBS group, n=15). Group 3: HSP27 and complete Freund's adjuvant or dosematched PBS was injected subcutaneously into the hind limb accompanied intraperitoneal injection of pertussis toxin [sensitized group(I-HSP27 group), n=15;I-PBS group, n=15)]. Group 4 was normal group without any treatment(n=5). IOPs of the rats were measured before, day 3, weeks 1, 2, 4, 6, and 8 after treatment. Paraffin-embedded sections were prepared for HE staining and RGCs apoptosis were detected by TUNEL. Anti-HSP27 level in serum and CSF were examined by ELISA. RESULTS: IOPs were elevated significantly in HP and V-HSP27, V-PBS groups(P<0.01) and positively related to anti-HSP27 levels in serum and CSFs. Anti-HSP27 levels in serum and CSF were elevated significantly in I-HSP27group compared to other groups(P<0.05). However, the IOPs did not show any relationship with the high-level antiHSP27 in serum and CSFs. RGC apoptosis were all elevated significantly in the HP, V-HSP27, V-PBS and I-HSP27 groups and also positively relative with anti-HSP27 level in serum and CSFs except that high-level of anti-HSP27 in the serum of I-HSP ***: The increases of anti-HSP27 levels in serum and CSFs both promote IOP escalation and the increase of RGC apoptosis in retina when anti-HSP27 is at low level. The case of high-level anti-HSP27 is opposite and show

关键词： intraocular pressure heat shock protein 27 retinal ganglion cells autoimmune apoptosis glaucoma rats

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Genomic evidence of lung carcinogenesis associated with coal smoke in Xuanwei area, China

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National Science Review 2021年第12期8卷 15-19页

作者： Honglei Zhang Chao Liu Li Li Xu Feng Qing Wang Jihua Li Shaobin Xu Shuting Wang Qianlu Yang Zhenghai Shen Jinhua Su Xiaosan Su Ruifen Sun Xuhong Zhou Junliang Wang Yongchun Zhou Baowei Jiao Wanbao Ding Xianbao Cao Yue Wang Yunchao Huang Lianhua Ye Center for Scientific Research Yunnan University of Chinese Medicine Department of Nuclear Medicine Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer Hospital Biotherapy Center Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Oncology Qujing First People's Hospital Qujing Center for Disease Control and Prevention Supercomputing Platform of kunming Institute of Zoology Kunming Biological Diversity Center of Instruments Kunming Institute of Zoology Chinese Academy of Sciences Department of Thoracic Surgery Ⅱ Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Thoracic Surgery Ⅰ Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Thoracic Surgery Xuanwei People's Hospital State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences Department of Oncology Yan'an Affiliated Hospital of Kunming Medical University Department of Otolaryngology First People's Hospital of Yunnan Province the Affiliated Hospital of Kunming University of Science and Technology The affiliated hospital of Guizhou medical university

Xuanwei area, in southwestern China,harbors the highest female lung cancer rate in the country(Supplementary Table 1) [1]. Epidemiological studies have shown that lung cancer incidence in Xuanwei area is associated with the use of different types of local coal for household cooking and heating [2]. The genomic landscape of Xuanwei female adenocarcinoma(XWFA), the most distinctive feature of lung cancer in Xuanwei, has yet to be elucidated systematically. Here,we provide the fundamental resource of genomic datasets for further exploration of XWFA molecular mechanisms and development of targetable therapy.

关键词： MUTATIONS

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Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet’s disease: A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3377-3383页

作者： Juan Luo Ying-Han Jiang Zi Lei Ying-Lei Miao Department of Gastroenterology the First Affiliated Hospital of Kunming Medical UniversityInstitute of Digestive DiseaseKunming 650000Yunnan ProvinceChina Department of Pathology the First People’s Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Pathology the First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a CD30-positive T cell lymphoma,a rare type of non-Hodgkin *** current World Health Organization classification system divides ALCLs into anaplastic lymphoma kinase(ALK)-positive and ALK-negative *** rarely presents in the gastrointestinal *** SUMMARY A 54-year-old male was admitted to the department of gastroenterology for abdominal *** presented with lower abdominal pain,diarrhea and recurrent oral and penile *** was misdiagnosed with Behcet's disease and treated with *** after one month,he was hospitalized in another hospital for *** time,the lesion on the penis was biopsied for histological *** final pathological diagnosis was ALCL,*** patient was treated with cyclophosphamide,doxorubicin,vincristine,prednisolone ***,he died within one *** Gastrointestinal ALCL needs to be considered in the differential diagnosis to avoid delaying *** biopsy is the most important for early diagnosis and treatment.

关键词： Anaplastic large cell lymphoma Anaplastic lymphoma kinase Behcet's disease Colon ulcer Penis ulcer Case report

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Hsa_circ_0136666 mediates the antitumor effect of curcumin in colorectal carcinoma by regulating CXCL1 via miR-1301-3p

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2120-2137页

作者： Shi Chen Wei Li Chen-Gong Ning Feng Wang Li-Xing Wang Chen Liao Feng Sun Department of Gastrointestinal Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of Blood Transfusion The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina

BACKGROUND This study investigate the anti-tumor effect of curcumin and whether its mediated by hsa_circ_0136666 through miR-1301-3p/CXCL1 in colorectal carcinoma(CRC).Through multiple experiments,we have drawn the conclusion that curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/CXCL1 axis,hinting at a novel treatment option for curcumin to prevent CRC *** To determine whether hsa_circ_0136666 involvement in curcumin-triggered CRC progression was mediated by sponging *** Cell counting kit-8,colony-forming cell,5-ethynyl-2’-deoxyuridine,and flow cytometry assays were carried out to determine cell proliferation,apoptosis,and cell cycle ***-time quantitative polymerase chain reaction quantified hsa_circ_0136666,miR-1301-3p,and chemokine(C-X-C motif)ligand 1(CXCL1),and western blot analysis determined CXCL1,B-cell lymphoma-2(Bcl-2),and Bcl-2 related X protein(Bax)protein *** or starbase software was first used for the prediction of miR-1301-3p binding with hsa_circ_0136666 and CXCL1,followed by RNA pull-down,RNA immunoprecipitation,and dualluciferase reporter assay *** vivo experiments were implemented in a murine xenograft *** Curcumin blocked CRC cell proliferation but boosted ***,elevated hsa_circ_0136666 Levels were observed in CRC cells,which were reduced by *** vitro,hsa_circ_0136666 overexpression abolished the antitumor activity of CRC *** analysis revealed the ability of hsa_circ_0136666 to sponge miR-1301-3p to modulate CXCL1 *** Curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/CXCL1 axis,hinting at a novel treatment option for curcumin to prevent CRC development.

关键词： Curcumin Hsa_circ_0136666 MiR-1301-3p CXCL1 Colorectal carcinoma

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Rare primary rectal mucosa-associated lymphoid tissue lymphoma with curative resection by endoscopic submucosal dissection:A case report and review of literature

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World Journal of Clinical Cases 2022年第21期10卷 7599-7608页

作者： Yan Tao Qiong Nan Zi Lei Ying-Lei Miao Jun-Kun Niu Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityYunnan Province Clinical Research Center for Digestive DiseasesKunming 650032Yunnan ProvinceChina Department of Pathology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)occurs in approximately 9%of non-Hodgkin B-cell *** gastrointestinal tract is the most commonly affected site of the extranodal forms of primary non-Hodgkin’s ***,it rarely occurs within the rectum,and at present,there is no consensus on its diagnosis and treatment at this *** SUMMARY We report a rare laterally spreading tumour-like rectal MALT lymphoma case in which the diagnosis and the depth of infiltration were determined by magnifying endoscopy and ultrasonic ***,the lesion was en bloc resected by endoscopic submucosal dissection(ESD)*** lesion was confirmed as MALT lymphoma by haematoxylin and eosin staining,immunohistochemical staining and gene arrangement *** exams have indicated a 2-year disease-free survival for this *** We report a rare primary rectal MALT lymphoma that was curable with resection by *** is a safe and effective therapeutic option for rectal MALT lymphoma.

关键词： Rectum Mucosa-associated lymphoid tissue lymphoma Endoscopic submucosal dissection En bloc resection Case report

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A rare complication after radiofrequency ablation in the treatment of colorectal liver metastasis: A case report

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Journal of Interventional Medicine 2020年第4期3卷 213-215页

作者： Rong Ding Jinmei Zhou Yinshan Yang Ling Zhao Shuai Luo Ming Huang Minimally Invasive Interventional Medicine Third Affiliated Hospital of Kunming Medical UniversityTumor Hospital of Yunnan ProvinceKunming650118PR China

Radiofrequency ablation(RFA)is one of the safe and effective treatments of colorectal cancer with liver metastasis,which has the advantages of minimally invasive,fewer complications,short hospitalization time and repeatable operation.A special case with advanced transverse colon carcinoma was treated by RFA in our *** the procedures were performed,which were recommended by the *** intestinal perforation occurred on the second day after the RFA,then surgeon performed emergency surgery,unfortunately,anastomotic leakage occurred on the 21st day after the operation,yet after conservative medical treatment,the patient achieved remission of symptoms and discharged from the *** complications occurred after RFA in the treatment of colorectal cancer with liver metastasis are unpredictable,which could affect the efficacy of RFA and performance status of *** investigation of the mechanism of these complications is warranted urgently,which might offer more effective methods against these rare complications.

关键词： metastasis treatment after

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Primary adrenal diffuse large B-cell lymphoma with normal adrenal cortex function:A case report

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World Journal of Clinical Cases 2022年第2期10卷 709-716页

作者： Zhi-Nan Fan Hong-Jin Shi Bo-Bo Xiong Jin-Song Zhang Hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma,which accounts for about approximately 30%to 40%of non-Hodgkin's lymphomas,is the most common type and is a class of aggressive B-cell ***,diffuse large B-cell lymphomas primary to the adrenal gland are *** SUMMARY A 73-year-old man was admitted with abdominal pain and *** admission,enhanced adrenal computed tomography indicated irregular masses on both adrenal glands,with the larger one on the left side,approximately 8.0 cm×4.3 cm in *** boundary was irregular,and surrounding tissues were *** obvious enhancement was observed in the arterial *** of the left adrenal gland was *** diagnosis revealed diffuse large B-cell *** surgery,the patient received RCHOP *** the fourth immunochemotherapy,patient condition deteriorated,and he eventually died of respiratory *** R-CHOP is the conventional immunochemotherapy for primary adrenal diffuse large B-cell *** is mainly used to diagnose the ***,the ideal treatment plan remains to be confirmed.

关键词： Large B-cell lymphoma Adrenal glands Immunochemotherapy Surgical procedures Case report

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Hypoparathyroidism with Fahr’s syndrome: A case report and review of the literature

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World Journal of Clinical Cases 2019年第21期7卷 3662-3670页

作者： Yuan-Yuan Zhou Ying Yang Hong-Mei Qiu Department of Endocrinology and Metabolism Fourth Affiliated Hospital of Kunming Medical University and The Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and Metabolism Sixth Affiliated Hospital of Kunming Medical University and The People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina

BACKGROUND Hypoparathyroidism with basal ganglia calcification is clinically ***,we report a case of Fahr’s syndrome due to hypoparathyroidism and review the literature in terms of etiology,clinical manifestation,diagnosis,and *** SUMMARY A 62-year-old man experienced repeated twitching of both hands in recent 10 *** July 28,2017,the patient was admitted to our hospital due to slow response and speech *** medical examinations,he had a positive Chvostek sign,while no Albright’s hereditary osteodystrophy signs or history of neck surgery or radiation,and his family members had no similar medical *** examinations revealed hypocalcemia,hyperphosphatemia,and low parathyroid hormone(PTH)*** tomography revealed basal ganglia *** on these investigations,a diagnosis of Fahr’s syndrome due to hypoparathyroidism was *** receiving intravenous calcium gluconate to relieve symptoms,the patient continued to take oral calcium carbonate and calcitriol for *** The possibility of hypoparathyroidism should be considered in patients with chronic hypocalcemia,recurrent tetany,and even neuropsychiatric *** is a common cause of basal ganglia ***,it is recommended that blood calcium,phosphorus,and PTH levels should be measured in all individuals with basal ganglia calcification to exclude hypoparathyroidism.

关键词： Hypoparathyroidism Hypocalcemia Fahr’s syndrome Case report

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Small-cell carcinoma of the prostate with negative CD56,NSE,Syn,and CgA indicators:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1630-1638页

作者： Hong-Jin Shi Zhi-Nan Fan Jin-Song Zhang Bo-Bo Xiong Hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting for<1%of all prostate ***,negativity for all SCCP neuroendocrine markers is ***,we report a case of SCCP with completely negative neuroendocrine markers and explore its clinicopathologic features,thus improving the understanding of its clinical diagnosis and *** SUMMARY We report the case of a 48-year-old patient with SCCP negative for common sensitive neuroendocrine-staining *** was the first symptom,and rectal examination revealed a hard prostate,palpable nodules,diffuse prostate enlargement,no pressure pain,no blood staining in the finger sleeve,1.33 ng/mL total prostate-specific antigen level,and a free-to-total prostate-specific antigen ratio of 0.21 ng/*** suggested a prostate size of 5.3 cm×5.8 cm×5.6 cm,and magnetic resonance imaging suggested prostate *** lower posterior bladder wall,rectal mesentery,and bilateral seminal vesicles were invaded,with multiple lymph node metastases in the pelvis.A whole-body bone scan suggested an abnormally active multiple bone metabolism and possible bone *** and lungs computed tomography revealed no significant nodal *** a pathological diagnosis of SCCP after a prostate puncture,with negative indicators of common sensitive neuroendocrine staining,chemotherapy was administered;the patient died 4-5 mo after SCCP *** SCCP is a rare disease characterized by atypical clinical symptoms,limited treatment options,a short survival period,and a poor prognosis.

关键词： Prostate cancer Small cell carcinoma Neuroendocrine tumor Therapeutics Diagnosis Case report

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