Genomic evidence of lung carcinogenesis associated with coal smoke in Xuanwei area, China

作     者：Honglei Zhang Chao Liu Li Li Xu Feng Qing Wang Jihua Li Shaobin Xu Shuting Wang Qianlu Yang Zhenghai Shen Jinhua Su Xiaosan Su Ruifen Sun Xuhong Zhou Junliang Wang Yongchun Zhou Baowei Jiao Wanbao Ding Xianbao Cao Yue Wang Yunchao Huang Lianhua Ye Honglei Zhang;Chao Liu;Li Li;Xu Feng;Qing Wang;Jihua Li;Shaobin Xu;Shuting Wang;Qianlu Yang;Zhenghai Shen;Jinhua Su;Xiaosan Su;Ruifen Sun;Xuhong Zhou;Junliang Wang;Yongchun Zhou;Baowei Jiao;Wanbao Ding;Xianbao Cao;Yue Wang;Yunchao Huang;Lianhua Ye

作者机构：Center for Scientific Research Yunnan University of Chinese Medicine Department of Nuclear Medicine Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer Hospital Biotherapy CenterThird Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Oncology Qujing First People's Hospital Qujing Center for Disease Control and Prevention Supercomputing Platform of Kunming Institute of Zoology Kunming Biological Diversity Center of Instruments Kunming Institute of Zoology Chinese Academy of Sciences Department of Thoracic Surgery Ⅱ Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Thoracic Surgery Ⅰ Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Department of Thoracic Surgery Xuanwei People's Hospital State Key Laboratory of Genetic Resources and EvolutionKunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences Department of Oncology Yan'an Affiliated Hospital of Kunming Medical University Department of Otolaryngology First People's Hospital of Yunnan Province the Affiliated Hospital of Kunming University of Science and Technology The Affiliated Hospital of Guizhou Medical University 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2021年第8卷第12期

页      面：15-19页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China (31801249,81860325, 81860513, 81760519 and 81760818,82060519, 81960322) Scientific Research Fund Project of Yunnan Education Department(2019J1313, 2017zzx197 and 2019J1061) The National Key Research and Development Program of China (2017YFC0907902 and2016YFE0103400-01) High-level Health Technology Personnel Training Program of Yunnan Province (L-2017006) Joint Program of Applied Basic Research of Yunnan Provincial Department of Science and Technology-Kunming Medical University (2019FE001 (-066), 2018FE001 (-247),2018FE001(-247)) Health research project of Kunming Health Committee (2019-03-10-006) Reserve talent project of young and middle-aged academic and technical leaders in Yunnan province(202005AC160048) Medical edible flowers technology innovation team of universities in Yunnan province (2020YGC01) Applied Basic Research Project of Yunnan (202001AU070096) Medical Reserve Personnel Training Program of Yunnan Provincial Health Commission (H-2018097) 

主　　题：MUTATIONS 

摘      要：Xuanwei area, in southwestern China,harbors the highest female lung cancer rate in the country(Supplementary Table 1) [1]. Epidemiological studies have shown that lung cancer incidence in Xuanwei area is associated with the use of different types of local coal for household cooking and heating [2]. The genomic landscape of Xuanwei female adenocarcinoma(XWFA), the most distinctive feature of lung cancer in Xuanwei, has yet to be elucidated systematically. Here,we provide the fundamental resource of genomic datasets for further exploration of XWFA molecular mechanisms and development of targetable therapy.