Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms:A bioinformatics study
作者机构：Department of Medical OncologyThe First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第12期
页 面：2150-2168页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.82260601 Joint Foundation of Kunming Medical University and Yunnan Provincial Science and Technology Department,No.202201AY070001-256 Grant for Clinical Medical Center of Yunnan Provincial Health Commission,No.2021LCZXXF-XH03 Young Academic Talents Cultivation Foundation of Yunnan Province,No.202205AC160070
主 题：Colorectal cancer DNA methylation Prognosis Diagnosis Bioinformatics Heat shock factor protein 4
摘 要：BACKGROUND We previously demonstrated that heat shock factor protein 4(HSF4)facilitates colorectal cancer(CRC)*** methylation,a major modifier of gene expression and stability,is involved in CRC development and *** To investigate the correlation between HSF4 methylation and CRC risk,and to uncover the underlying molecular *** Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource ***4 methylation-related genes were identified by LinkedOmics in CRC,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE *** A total of 19 CpG methylation loci were identified in HSF4,and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA ***,the prognostic and diagnostic performance of these CpG loci in CRC patients was *** CRC,there were 1694 HSF4 methylation-related genes;1468 of which displayed positive and 226 negative associations,and they were involved in regulating phenotypes such as immune,inflammatory,and metabolic ***,RELA,STAT3,FCGR3A,POLR2K,and AXIN1 are hub genes among the HSF4 methylation-related *** HSF4 is highly methylated in CRC,but there is no significant correlation between it and the prognosis and diagnosis of ***4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.
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