Small-cell carcinoma of the prostate with negative CD56,NSE,Syn,and CgA indicators:A case report

作     者：Hong-Jin Shi Zhi-Nan Fan Jin-Song Zhang Bo-Bo Xiong Hai-Feng Wang Jian-Song Wang 

作者机构：Department of UrologyThe Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第5期

页      面：1630-1638页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China No.81972395 and No.82060464 

主　　题：Prostate cancer Small cell carcinoma Neuroendocrine tumor Therapeutics Diagnosis Case report 

摘      要：BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting for1%of all prostate ***,negativity for all SCCP neuroendocrine markers is ***,we report a case of SCCP with completely negative neuroendocrine markers and explore its clinicopathologic features,thus improving the understanding of its clinical diagnosis and *** SUMMARY We report the case of a 48-year-old patient with SCCP negative for common sensitive neuroendocrine-staining *** was the first symptom,and rectal examination revealed a hard prostate,palpable nodules,diffuse prostate enlargement,no pressure pain,no blood staining in the finger sleeve,1.33 ng/mL total prostate-specific antigen level,and a free-to-total prostate-specific antigen ratio of 0.21 ng/*** suggested a prostate size of 5.3 cm×5.8 cm×5.6 cm,and magnetic resonance imaging suggested prostate *** lower posterior bladder wall,rectal mesentery,and bilateral seminal vesicles were invaded,with multiple lymph node metastases in the pelvis.A whole-body bone scan suggested an abnormally active multiple bone metabolism and possible bone *** and lungs computed tomography revealed no significant nodal *** a pathological diagnosis of SCCP after a prostate puncture,with negative indicators of common sensitive neuroendocrine staining,chemotherapy was administered;the patient died 4-5 mo after SCCP *** SCCP is a rare disease characterized by atypical clinical symptoms,limited treatment options,a short survival period,and a poor prognosis.