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Vehicular volatile organic compounds losses due to refueling and diurnal process in China: 2010–2050

Journal of Environmental Sciences 2015年第7期27卷 88-96页

作者： Xiaofan Yang Huan Liu Hongyang Cui Hanyang Man Mingliang Fu Jiming Hao Kebin He School of Environment State Key Joint Laboratory of Environment Simulation and Pollution Control Tsinghua University state Environmental Protection key laboratory of Sources and Control of Air Pollution Complex Collaborative Innovation Center for Regional Environmental quality

Volatile organic compounds（VOCs） are crucial to control air pollution in major chinese cities since VOCs are the dominant factor influencing ambient ozone level, and also an important precursor of secondary organic aerosols. Vehicular evaporative emissions have become a major and growing source of VOC emissions in China. This study consists of lab tests, technology evaluation, emissions modeling, policy projections and cost-benefit analysis to draw a roadmap for China for controlling vehicular evaporative emissions. The analysis suggests that evaporative VOC emissions from China＇s light-duty gasoline vehicles were approximately 185,000 ton in 2010 and would peak at 1,200,000 ton in 2040 without control. The current control strategy implemented in China, as shown in business as usual（BAU） scenario, will barely reduce the long-term growth in emissions. Even if Stage II gasoline station vapor control policies were extended national wide（BAU ＋ extended Stage II）, there would still be over 400,000 ton fuel loss in 2050. In contrast, the implementation of on-board refueling vapor recovery（ORVR） on new cars could reduce 97.5% of evaporative VOCs by 2050（BAU ＋ ORVR/BAU ＋ delayed ORVR）. According to the results, a combined Stage II and ORVR program is a comprehensive solution that provides both short-term and long-term benefits. The net cost to achieve the optimal total evaporative VOC control is approximately 62 billion CNY in 2025 and 149 billion CNY in 2050.

关键词： Evaporative VOC emissions China roadmap Vehicle Refueling emission control

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Natural products against hematological malignancies and identification of their targets

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Science China(Life Sciences) 2015年第12期58卷 1191-1201页

作者： XU Ying LIU JinBao WU YingLi GUO QingLong SUN HanDong CHEN GuoQiang Department of Pathophysiology Chemical Biology Division of Shanghai Universities E-Institutes Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education Shanghai Jiao Tong University School of Medicine Institute of Health Sciences Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences-Shanghai Jiao Tong University School of Medicine state key laboratory of Respiratory Disease Protein Modification and Degradation Lab Department of Pathophysiology Guangzhou Medical University state key laboratory of Natural medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University state key laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Naturally occurring molecules derived from higher plants, animals, microorganisms and minerals play an important role in the discovery and development of novel therapeutic agents. The identification of molecular targets is of interest to elucidate the mode of action of these compounds, and it may be employed to set up target-based assays and allow structure-activity relationship studies to guide medicinal chemistry efforts toward lead optimization. In recent years, plant-derived natural compounds possessing potential anti-tumor activities have been garnering much interest and efforts are underway to identify their molecular targets. Here, we attempt to summarize the discoveries of several natural compounds with activities against hematological malignancies, such as adenanthin, oridonin, gambogic acid and wogonoside, the identification of their targets, and their modes of actions.

关键词： natural products adenanthin hematological malignancies target identification

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Prediction of quality markers of traditional chinese medicines based on network pharmacology

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chinese Herbal medicines 2019年第4期11卷 349-356页

作者： Yu-li Wang Tao Cui Ya-zhuo Li Mao-liang Liao Hong-bing Zhang Wen-bin Hou Tie-jun Zhang Liang Liu He Huang Chang-xiao Liu key laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China Tianjin key laboratory of quality-marker of Traditional chinese medicines Tianjin Institute of Pharmaceutical ResearchTianjin 300193China state key laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China Tianjin University of Traditional chinese Medicine Tianjin 300193China state key laboratory of quality research of chinese medicines Macao University of Science and TechnologyMacao SARChina

Network pharmacology is a powerful tool to reflect the pharmacologically active effects,mechanism of action and toxic activity of traditional chinese medicines(TCMs).The ingredients of TCMs,associated with quality control of TCM products,are those fundamental chemicals that exhibit biological activities.A great amount of effort has been made by scientists in that field in order to improve the quality of TCMs,though the approaches to determine their quality and the TCM theory and compatibility rules remain *** some methods and technologies must be applied to predict and explore the quality marker(Q-marker)for quality control,as well as to clarify the factors affecting the quality of TCM,which may give new insight into rational ground of establishment of appropriate quality control and assessment *** this review paper,authors focus on the prediction of quality markers of TCMs by network pharmacology based on three aspects:(1)from network medicine to network pharmacology,(2)complex network system of traditional chinese medicine,and(3)predicting TCM quality markers based on network *** proposed the research pattern on network pharmacology based on biological and medical networks,and further TCM network pharmacology based on substantial basis of TCM formulae,and the idea of"effect-ingredient-target-fingerprint"to predict and recognize the TCM Qmarker was the ultimate *** addition,authors yet noted how to make full use of the advantages of network toxicology to provide new ideas for the toxicity study of complex TCM systems and the prediction of TCM toxicity markers.

关键词： network pharmacology network toxicology prediction quality marker traditional chinese medicines

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Stable-isotope probing of bacterial community for dissolved inorganic carbon utilization in Microcystis aeruginosa-dominated eutrophic water

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Journal of Environmental Sciences 2019年第5期31卷 264-272页

作者： Weiguo Zhang Jiangye Li Chengcheng Wang Xue Zhou Yan Gao Zhongjun Jia Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural Sciences key lab of Food quality and Safety of Jiangsu Province-state key laboratory Breeding Base China Ministry of Agriculture key laboratory at Yangtze River Plain for Agricultural Environment College of Resources and Environmental Sciences Nanjing Agricultural University College of Water Conservancy and Hydropower Engineering Hohai University Institute of Soil Science Chinese Academy of Sciences

Dissolved inorganic carbon(DIC) is an important source of carbon in aquatic ecosystems,especially under conditions of increased frequency of cyanobacterial bloom. However, the importance of bacteria in direct or indirect utilization of DIC has been widely overlooked in eutrophic freshwater. To identify the functional bacteria that can actively utilize DIC in eutrophic freshwater during cyanobacterial bloom, stable-isotope probing(SIP) experiments were conducted on eutrophic river water with or without inoculation with cyanobacteria(Microcystis aeruginosa). Our 16 S rRNA sequencing results revealed the significance of Betaproteobacteria, with similar relative abundance as Alphaproteobacteria, in the active assimilation of H^(13)CO^(3-) into their DNA directly or indirectly, which include autotrophic genera Betaproteobacterial ammonia-oxidizing bacteria. Other bacterial groups containing autotrophic members, e.g. Planctomycetes and Nitrospira, also presented higher abundance among free-living bacteria in water without cyanobacteria. Microcystis aggregates showed a preference for some specific bacterial members that may utilize H^(13)CO^(3-) metabolized by Microcystis as organic matter, e.g. Bacteroidetes(Cytophagales, Sphingobacteriales), and microcystindegrading bacteria Betaproteobacteria(Paucibacter/Burkholderiaceae). This study provides some valuable information regarding the functional bacteria that can actively utilize DIC in eutrophic freshwater.

关键词： Dissolved inorganic carbon Stable isotope probing Eutrophication Microcystis aeruginosa

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Voltage-gated K^+channels promote BT-474 breast cancer cell migration

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chinese Journal of Cancer research 2018年第6期30卷 613-622页

作者： Louis WC Chow Ka-Shun Cheng Kar-Lok Wong Yuk-Man Leung state key laboratory of quality research in chinese medicines Macao University of Science and TechnologyTaipaMacao 999078China UNIMED Medical Institute Hong Kong 999077China Organisation for Oncology and Translational research Hong Kong 999077China Department of Anesthesiology China Medical University HospitalTaiehung 40447TaiwanChina Department of Anesthesiology the Qingdao University Yuhuangding HospitalYantai 264000China Department of Physiology China Medical UniversityTaichung 40402TaiwanChina

Objective: A variety of ion channels have been implicated in breast cancer proliferation and *** K+(Kv) channels not only cause repolarization in excitable cells,but are also involved in multiple cellular functions in non-excitable *** this study we investigated the role of Kv channels in migration of BT474 breast cancer ***: Transwell technique was used to separate migratory cells from non-migratory ones and these two groups of cells were subject to electrophysiological examinations and microfluorimetric measurements for cytosolic *** migration was examined in the absence or presence of Kv channel ***: When compared with non-migratory cells,migratory cells had much higher Kv current densities,but rather unexpectedly,more depolarized membrane potential and reduced *** transcriptasepolymerase chain reaction(RT-PCR) analysis revealed the presence of Kv1.1,Kv1.3,Kv1.5,Kv2.1,Kv3.3,Kv3.4 and Kv4.3 *** migration was markedly inhibited by tetraethylammonium(TEA),a delayed rectifier Kv channel blocker,but not by 4-aminopyridine,an A-type Kv channel ***: Taken together,our results show that increased Kv channel expression played a role in BT474 cell migration,and Kv channels could be considered as biomarkers or potential therapeutic targets for breast cancer *** mechanism(s) by which Kv channels enhanced migration appeared unrelated to membrane hyperpolarization and Cainflux.

关键词： Breast cancer Kv channels migration biomarkers

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Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cαand inhibiting deposition of extracellular matrix

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中国天然药物:英文版 2023年第8期21卷 599-609页

作者： LIU Yue YANG Yating WANG Hanghang LI Han LV Qi WANG Xiachang WU Dalei HU Lihong ZHANG Yinan Jiangsu key laboratory for Functional Substances of chinese Medicine School of PharmacyNanjing University of Chinese MedicineNanjing 210023China Helmholtz International lab State Key Laboratory of Microbial TechnologyShandong UniversityQingdao 266237China

Gypenosides,structurally analogous to ginsenosides and derived from a sustainable source,are recognized as the principal active compounds found in Gynostemma pentaphyllum,a chinese medicinal plant used in the treatment of the metabolic *** bioactive tracking isolation of the plants collected from different regions across China,we obtained four new gypenosides(1−4),together with nine known gypenosides(5−13),from the methanol extract of the *** structures of new gypenosides were elucidated by one-dimensional(1D)and two-dimensional(2D)nuclear magnetic resonance(NMR)spectra,complemented by chemical degradation *** comprehensive evaluation involving COL1A1 promoter assays and PP2Cαactivity assays,we established a definitive structure-activity relationship for these dammarane-type triterpenoids,affirming the indispensability of the C-3 saccharide chain and C-17 lactone ring in effectively impeding extracellular matrix(ECM)deposition within hepatic stellate *** in vivo study on the CCl4-induced liver damage mouse model corroborated that compound 5 significantly ameliorated the process of hepatic fibrosis by oral *** results underscore the potential of dammarane-type triterpenoids as prospective antifibrotic leads and highlight their prevalence as key molecular frameworks in the therapeutic intervention of chronic hepatic disorders.

关键词： Dammarane-type triterpenoid Gypenoside Liver fibrosis Extracellular matrix

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Limitation standard of toxic aconitines in Aconitum proprietary chinese medicines using on-line extraction electrospray ionization mass spectrometry

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1511-1520页

作者： Zi-Dong Qiu Xu-Ya Wei Rui-Qi Sun Jin-Long Chen Ting Tan Jia-Quan Xu Guang-Hong Cui Tong Chen Juan Guo Chang-Jiang-Sheng Lai Lu-Qi Huang state key laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China The National Pharmaceutical Engineering Center for Solid Preparation in chinese Herbal Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330006China state key laboratory of Natural medicines China Pharmaceutical UniversityNanjing 210009China Jiangxi key laboratory for Mass Spectrometry and Instrumentation College of ChemistryBiology and Material SciencesEast China Institute of TechnologyNanchang 330013China

Development of rapid analytical methods and establishment of toxic component limitation standards are of great importance in quality control of traditional chinese medicine. Herein, an online extraction electrospray ionization mass spectrometry(oEESI-MS) coupled with a novel whole process integral quantification strategy was developed and applied to direct determination of nine key aconitine-type alkaloids in 20 Aconitum proprietary chinese medicines(APCMs). Multi-type dosage forms(e.g., tablets, capsules, pills, granules, and liquid preparation) of APCM could be determined directly with excellent versatility. The strategy has the characteristics of high throughput, good tolerance of matrix interference, small amount of sample(~0.5 mg) and reagent(~240 μL) consumption, and short analysis time for single sample(chinese Pharmacopoeia severally, and turned out that HWT-based toxicity evaluation results were closer to the real clinical applications. Hence,a more accurate and reliable APCM toxicity limitation was established and expected to play an important guiding role in clinics. The current study extended the power of ambient MS as a method for the direct quantification of molecules in complex samples, which is commonly required in pharmaceutical analysis,food safety control, public security, and many other disciplines.

关键词： Aconitum dosage tablets

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A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species

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chinese Journal of Natural medicines 2020年第1期18卷 1-27页

作者： YUE Han ZENG Hui DING Kan Glycochemistry and Glycobiology lab Key Laboratoty of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of chinese Academy of Sciences Beijing 100049China

Dendrobium,orchid,is a traditional chinese herb medicine applied extensively as tonic and precious food for thousands of years recorded in ancient chinese medical book"Shen Nong’s Materia Medica".It’s well known that bioactivities are usually related to the ingredients’*** on the previous research,Dendrobium species contain amino acid,sesquiterpenoids,alkaloids and *** the bioactive substances,carbohydrate shows extensive activities in antitumor,antiglycation,immune-enhancing,antivirus,antioxidant,antitumor and ***,as the main biologically active substance,the exact structures and latent activities of polysaccharides from Dendrobium species are widely focused *** this review,we focus on the advancements of extraction methods and diversity of structures and bioactivities of polysaccharides obtained from Dendrobium species.

关键词： Dendrobium Polysaccharides Bioactivities Structures

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Chromosome-level genome assembly of Salvia miltiorrhiza with orange roots uncovers the role of Sm2OGD3 in catalyzing 15,16-dehydrogenation of tanshinones

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Horticulture research 2023年第6期10卷 30-42页

作者： Xian Pan Yujie Chang Caili Li Xiaoxiao Qiu Xinyun Cui Fanqi Meng Sixuan Zhang Xian’en Li Shanfa Lu key lab of chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering research Center of chinese Medicine Resource Ministry of EducationBeijing 100193China

Salvia miltiorrhiza is well known for its clinical practice in treating heart and cardiovascular *** roots,used for traditional chinese medicine materials,are usually brick-red due to accumulation of red pigments,such as tanshinone IIA and tanshinone *** we report a *** line(shh)with orange *** with the red roots of normal *** plants,the contents of tanshinones with a single bond at C-15,16 were increased,whereas those with a double bond at C-15,16 were significantly decreased in *** assembled a high-quality chromosome-level genome of *** analysis showed that the relationship between two *** lines with red roots was closer than the relationship with *** indicates that shh could not be the mutant of an extant *** line with red *** genomic and transcriptomic analyses showed that a 1.0 kb DNA fragment was deleted in shh *** assay showed that overexpression of intact Sm2OGD3 in shh hairy roots recovered furan D-ring tanshinone ***,in vitro protein assay showed that Sm2OGD3 catalyzed the conversion of cyptotanshinone,15,16-dihydrotanshinone I and 1,2,15,16-tetrahydrotanshinone I into tanshinone IIA,tanshinone I and 1,2-dihydrotanshinone I,***,Sm2OGD3 functions as tanshinone 15,16-dehydrogenase and is a key enzyme in tanshinone *** results provide novel insights into the metabolic network of medicinally important tanshinone compounds.

关键词： OGD roots orange

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Genome-wide identification of abscisic acid(ABA) receptor pyrabactin resistance 1-like protein(PYL) family members and expression analysis of PYL genes in response to different concentrations of ABA stress in Glycyrrhiza uralensis

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chinese Journal of Natural medicines 2020年第8期18卷 606-611页

作者： CUI Ying-Xian XU Zhi-Chao CHEN Xin-Lian NIE Li-Ping WU Li-Wei WANG Yu SONG Jing-Yuan YAO Hui key lab of chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering research Center of chinese Medicine Resources Ministry of EducationBeijing 100193China

As abscisic acid(ABA)receptor,the pyrabactin resistance 1-like(PYR/PYL)protein(named PYL for simplicity)plays an important part to unveil the signal transduction of ABA and its regulatory *** uralensis,a drought-tolerant medicinal plant,is a good model for the mechanism analysis of ABA response and active compound ***,knowledge about PYL family in *** remains largely ***,10 PYLs were identified in *** *** analysis indicated that PYLs in ***(Gu PYLs)are relatively *** analysis showed that Gu PYL1-3 belongs to subfamily I,Gu PYL4-6 and Gu PYL10 belong to subfamily II and Gu PYL7-9 belongs to subfamily *** addition,transcriptome data presented various expression levels of Gu PYLs under different exogenous ABA *** expression pattern of Gu PYLs was verified by Quantitative real-time polymerase chain reaction(q RT-PCR).The study proved that Gu PYL4,Gu PYL5,Gu PYL8 and Gu PYL9 genes are significantly up-regulated by ABA stress and the response process is *** study paves the way for elucidating the regulation mechanism of ABA signal to secondary metabolites and improving the cultivation and quality of *** using agricultural strategies.

关键词： Glycyrrhiza uralensis Abscisic acid Pyrabactin resistance 1-like(PYR/PYL)protein family Gene expression Signaling pathway Stress responses

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