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Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

Journal of Genetics and Genomics 2024年第3期51卷 338-351页

作者： Qian Zhang Yongjie Wang Jie Tao Ruixue Xia Yijie Zhang Zhirui Liu Jiwei Cheng Department of Neurology and Central Laboratory Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China school of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Department of Respiratory and Critical Care Medicine Henan University Huaihe HospitalKaifengHenan 475099China

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the *** exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is ***,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic *** transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune *** type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and *** microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like ***,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of *** pioneering study describes the landscape of the transcriptome in the hippocampus of autistic *** elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

关键词： Autistic spectrum disorder(ASD) Sex Single cell Neurons Microglia

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Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-Li Zheng Department of Basic Medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal *** To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying *** To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with *** determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance *** a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic *** effectively controlled blood glucose and food intake while protecting islet *** analysis revealed significant differences between the HFD and HFDLGZG *** intervention reduced branched-chain amino acid *** of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased *** may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by *** Our study strongly suggests that LGZG decoction reduces HFD-induced *** may activate S6K1 via metabolic *** findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

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Energy Efficiency Analysis of Multi-Antenna Cellular Networks with Strategic Sleep Relay

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China Communications 2018年第9期15卷 136-146页

作者： Yonghong Chen Jie Yang Xuehong Cao Shibing Zhang Department of Communication and Information Engineering Nanjing University of Posts and Telecommunications xinglin College Nantong University Department of Communication Engineering Nanjing Institute of Technology school of Electronics and Information Nantong University

Energy efficiency(EE) of cellular networks has attracted considerable attention recently. However, EE of relay-assisted cellular networks where the macro base stations(MBSs) are equipped with the multi-antenna has not been thoroughly addressed. This paper considered the downlink transmission of multi-antenna relay-assisted cellular networks, meanwhile, a strategic sleep scheme was used in relay stations(RSs), which dynamically adjusted the RS working mode according to whether the number of users serviced by the relay exceeds a given threshold. A geometric model was built to derive the coverage probability and mean achievable rate from the MBSs to user(UE), the MBS to RS, the RS to UE links and analyze the system EE. It is shown that the energy efficiency of cellular network with strategic sleep RS is slightly higher than that of cellular network with non-sleeping strategy. Furthermore, the MBS equipped with multi-antenna has better impact on energy efficiency and spectral efficiency than the MBS with single antenna.

关键词：多天线网络细胞精力睡觉效率分析接力继电器

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Remote stereocontrol in the(4+2)cycloadditions of 1,7-zwitterions:Asymmetric synthesis of multifunctionalized tetrahydroquinoline derivatives

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Chinese Chemical Letters 2024年第1期35卷 222-226页

作者： Chen Chen Jin Zhou Jing Jiang Yang Li Ting Mao Cheng Peng Gu Zhan Wei Huang State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

The scope of stereochemistry recognition usually occurs near the chiral scaffold of a ligand or *** stereocontrol,which can surpass the limits of stereorecognition of remote prochiral centers,has long been a challenging object of great interest in asymmetric *** current work realized the remote stereocontrol of 1,7-zwitterion intermediates formed from Huang's o-amino aryl MBH *** simple and easily accessibleβ-ICD as the bifunctional catalyst,multifunctionalized tetrahydroquinoline derivatives could be synthesized via(4+2)cycloadditions with excellent enantioselectivity and diastereoselectivity under mild *** strategy possesses broad substrate scope,and three types of electron-deficient enones are successfully *** studies disclosed the Lewis base-catalyzed reaction pathway,and H-bonding between the catalyst and enones is crucial for long-range ***-up reaction and transformations of the tetrahydroquinoline products demonstrated the potential of this strategy.

关键词： Asymmetric synthesis Tetrahydroquinoline Remote stereocontrol Pyrazolone Lewis base catalysis 1,7-Zwitterion

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Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

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World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-Fu Yuan Qin Cao Xiao-Yan Chen Yuan-Ye Jiang Wen-Min Dong Li-Li Guo Department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China Department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis©The Author(s)2024.Published by Baishideng Publishing Group Inc.All rights reserved.

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Joint Beamforming and Time Switching Designs for Energy-Constrained Cognitive Two-Way Relay Networks

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China Communications 2020年第5期17卷 110-118页

作者： Meijuan Zhang Shibing Zhang Zhihua Bao Wei Wang Xiaoge Zhang Yonghong Chen school of Information Science and Technology Nantong UniversityNantong 226019China Nantong Research Institute for Advanced Communication Technology Nantong 226019China xinglin College Nantong UniversityNantong 226019China

In this paper, we investigate a joint beamforming and time switching(TS) design for an energy-constrained cognitive two-way relay(TWR) network. In the network, the energy-constrained secondary user(SU) relay employs TS protocol to harvest energy from the signals sent by the circuit-powered primary user(PU) transmitter, and then exploits the harvested energy to perform information forwarding. Our aim is to maximize the sum rate of SUs under the constraints of the data rate of PU, the energy harvesting and the transmit power of the SU relay. To determine the beamforming matrix and TS ratio, we decouple the original non-convex problem into two subproblems which can be solved by semidefinite relaxation and successive convex optimization methods. Furthermore, we derive closed form expressions of the optimal solutions for each subproblem, which facilitates the design of a suboptimal iterative algorithm to handle the original sum rate maximization problem. Simulation results are presented to illustrate the effectiveness and superior performance of the proposed joint design against other conventional schemes in the literature.

关键词： cognitive networks two-way relay sum rate energy harvesting beamforming

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A Survey on Heliumspeech Communications in Saturation Diving

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China Communications 2020年第6期17卷 68-79页

作者： Shibing Zhang Lili Guo Hongjun Li Zhihua Bao Xiaoge Zhang Yonghong Chen school of Information Science and Technology Nantong UniversityNantong 226019China Nantong Research Institute for Advanced Communication Technology Nantong 226019China xinglin College Nantong UniversityNantong 226019China

With the development of society and the progress of technology,more and more ocean activities are carried *** results in booming of deep-sea *** use of helium-oxygen mixture(as a kind of breathing gas)solves the physiological problems of divers in saturated diving,but it brings about the Heliumspeech voice communication problem,the drop of speech *** is no doubt that the effective speech communication must be provided for supporting the life and work of divers in *** paper describes the mechanism of forming heliumspeech,discusses the effects of pressure and helium environment on the speech spectrum,compares the pros and cons of the time-domain and frequency-domain unscrambling techniques,shows the challenges in heliumspeech ***,it briefly introduces the deep learning,and points out that deep learning/machine learning may be a perfectly unscrambling technique.

关键词： maritime communications saturation diving heliumspeech unscrambling challenging deep learning

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Cordyceps as potential therapeutic agents for atherosclerosis

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Journal of Integrative Medicine 2024年第2期22卷 102-114页

作者： Yi Zhang Si-jing Liu school of Marxism Chengdu University of Traditional Chinese MedicineChengdu 61137Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases with Integrated Chinese and Western Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina

Atherosclerosis is a leading cause of mortality and morbidity *** the challenges in managing atherosclerosis,researchers continue to investigate new treatments and complementary *** is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for *** studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions,including anti-inflammatory and antioxidant activities,lowering cholesterol,inhibiting platelet aggregation,and modulating apoptosis or autophagy in vascular endothelial ***,the current misuse of the terms cordyceps and Ophiocordyceps sinensis has caused confusion among researchers,and complicated the current academic research on *** review focuses on the chemical composition,pharmacological actions,and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of Ophiocordyceps *** review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.

关键词： Atherosclerosis Cordyceps Ophiocordyceps sinensis

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The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

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Journal of Pharmaceutical Analysis 2024年第2期14卷 157-176页

作者： Tao Zhang Lei Xu Xiaowei Guo Honglin Tao Yue Liu Xianfeng Liu Yi Zhang Xianli Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China school of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620032China

Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic *** addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately *** information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,*** play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).

关键词： Heart failure Silent information regulator 1 Adenosine monophosphate-activated protein kinase Traditional Chinese medicine

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Energy Efficiency Optimization for Heterogeneous Cellular Networks Modeled by Matérn Hard-Core Point Process

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China Communications 2020年第8期17卷 70-80页

作者： Yonghong Chen Jie Yang Xuehong Cao Shibing Zhang Department of Communication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China xinglin College Nantong UniversityNantong 226019China Department of Communication Engineering Nanjing Institute of TechnologyNanjing 211167China school of Information Science and Technology Nantong UniversityNantong 226019China

The Poisson point process(PPP) has been widely used in wireless network modeling and performance analysis due to the independence between its nodes. Therefore, it may not be a suitable model for many of the exclusive networks between the nodes. This paper analyzes the energy efficiency(EE) and optimizes the two-tier heterogeneous cellular networks(Het Nets). Considering the mutual exclusion between macro base stations(MBSs) distribution, the deployment of MBSs is modeled by the Matérn hard-core point process(MHCPP), and the deployment of pico base stations(PBSs) is modeled by the PPP. We adopt a simple approximation method to study the signal to interference ratio(SIR) distribution in two-tier MHCPP-PPP networks and then derive the coverage probabilities, the average data rates and the energy efficiency of Het Nets. Finally, an optimization algorithm is proposed to improve the EE of Het Nets by controlling the transmit power of PBSs. The simulation results show that the EE of a system can be effectively improved by selecting the appropriate transmit power for the PBSs. In addition, two-tier MHCPP-PPP Het Nets have higher energy efficiency than two-tier PPP-PPP Het Nets.

关键词： energy efficiency heterogeneous cellular networks coverage probability matérn hard-core point process

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