The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

作     者：Tao Zhang Lei Xu Xiaowei Guo Honglin Tao Yue Liu Xianfeng Liu Yi Zhang Xianli Meng Tao Zhang;Lei Xu;Xiaowei Guo;Honglin Tao;Yue Liu;Xianfeng Liu;Yi Zhang;Xianli Meng

作者机构：State Key Laboratory of Southwestern Chinese Medicine ResourcesInnovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese MedicineMeishanSichuan620032China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2024年第14卷第2期

页      面：157-176页

核心收录：

学科分类：09[农学] 090203[农学-茶学] 0902[农学-园艺学] 

基　　金：supported by the Natural Science Foundation of China(Grant No.:82130113) the“Xinglin Scholars”Research Promotion Program of Chengdu University of Traditional Chinese Medicine(Program No.:ZDZX2022005) the China Postdoctoral Science Foundation(Grant No.:2021MD703800) the Science Foundation for Youths of Science&Technology Department of Sichuan Province(Grant No.:2022NSFSC1449) 

主　　题：Heart failure Silent information regulator 1 Adenosine monophosphate-activated protein kinase Traditional Chinese medicine 

摘      要：Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic *** addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately *** information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,*** play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).