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Comparative Evaluation and Performance Analysis of Heat Exchangers Featured with Peened Surface

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Journal of Thermal Science 2025年第1期 50-61页

作者： DINESHBABU Chinnadurai SHIVA SANKARAN Nallasamy VENKATESH RAJA Krishnan VENKATESH Rathinavelu Department of Mechanical Engineering Kongunadu College of Engineering and Technology Department of Mechanical Engineering Selvam College of Technology Department of Mechanical Engineering Sona College of Technology Department of Mechanical Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences (SIMATS)Saveetha University

Heat exchangers have the potential for various engineering applications,and their performance is enriched by surface *** proposed system enriches the heat exchanger's performance by adapting a peened stainless steel（SS） surface blasted with copper,grinding,sand,and *** influences peened SS surface modified with a copper blast,grinding,sandblast,and iron blast on the surface morphology of shell and tube heat exchanger surface（STHE） is analyzed via tungsten heated cathode electron gun featured scanning electron microscope and observed coarse grain *** SS surface featured STHE performance is experimentally evaluated by different flow rates（30,60,90,and 120 L/min） underwater fluid medium functioned by the temperature ranges of 25-75℃ and its results are compared with computational fluid dynamic（CFD）/heat transfer research（HTRI） analyzed *** 60 L/min flow rate was spotted as an optimum value for both shell and tube side *** STHE is operated with a 60 L/min flow rate under the different peened surfaces and evaluated its Stanton number,Nusselt number,logarithmic mean temperature difference（LMTD）,overall heat transfer coefficient,number of transfer units（NTU）,effectiveness,and exergy *** iron blasted SS peened surface was observed to have better SHTE performance like Stanton number（0.0012）,Nusselt number（2180）,reduced LMTD of 31℃,improved overall heat transfer co-efficient of 2400 W/（m2·K）,better NTU of 0.5532,good effectiveness value of 0.451 62,and hiked exergy efficiency of 10% respectively.

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Fabrication of chitosan/silica hybrid coating on AZ31 Mg alloy for orthopaedic applications

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Journal of Magnesium and Alloys 2023年第2期11卷 614-628页

作者： M.Kalaiyarasan S.Pugalmani N.Rajendran Department of Chemistry CEG CampusAnna UniversityChennai600025Tamil NaduIndia Department of Orthodontics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical ScienceSaveetha UniversityChennai-600077India

Biocompatible conversion of chitosan and chitosan/silica hybrid coating were prepared to enhance the biocompatibility and corrosion resistance of biodegradable AZ31 Mg alloy. The coatings were optimized and analysed with potentiodynamic polarization, SEM, ATR-IR and XPS studies. Potentiodynamic polarization studies, revealed that the coatings exhibited high corrosion resistance. The surface morphology of the Ch-3/Si coating showed small globular rough structure. The presence of functional groups was confirmed by ATR-IR. For a better understanding of chitosan/silica hybrid coating, the chemical states were examined by XPS studies. The in-vitro bioactivity of the coated samples was evaluated in Earle’s solution, which formed a dense layer of coral-like structure and calcium-deficient apatite with less stoichiometric ratio than the hydroxyapatite. In-vitro cell culture studies exhibited a good cell proliferation rate and the fabricated Ch-3/Si coating was found to be non-hemolytic. The bacterial studies proved that Ch-3/Si coating possessed inherent antibacterial activity.

关键词： AZ31 Mg alloy Chitosan/silica Hemocompatibility MTT assay and antibacterial Studies

Identification of miR-802-5p and its involvement in type 2 diabetes mellitus

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World Journal of Diabetes 2020年第12期11卷 567-571页

作者： Kaushik Vishnu Rajkumar Ganesh Lakshmanan Durairaj Sekar Department of Anatomy Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical Science(SIMATS)Saveetha UniversityChennai 600077India dental Research Cell and Biomedical Research Unit(DRC-BRULAC) Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical Science(SIMATS)Saveetha UniversityChennai 600077India

MicroRNAs(miRNA)are recently discovered endogenous,small noncoding RNAs(of 22 nucleotides)that play pivotal roles in gene *** are involved in post-transcriptional control of gene *** are emerging as important regulators of cell proliferation,development,cancer formation,stress responses,cell death and physiological *** evidence has demonstrated the human miRNAs bind to their target mRNA sequences with perfect or near-perfect sequence *** provides a powerful strategy for discovering potential type 2 diabetes mellitus(T2DM)targets and gives the probability to exploit them for diagnostic and therapeutic *** 6%of the world population is affected by T2DM,and it is recognized as a global epidemic by the World Health *** present there is no valid biomarker to control or manage ***,the present study applied a mature sequence of miRNAs from publicly accessible databases to identify the miRNA from T2DM expressed sequence tags,and the results are detailed and discussed below.

关键词： MicroRNAs Type 2 diabetes mellitus miR-802-5p Biomarker Expressed sequence tags Disease

Dissecting the theranostic potential of exosomes in autoimmune disorders

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Cellular & Molecular Immunology 2019年第12期16卷 935-936页

作者： Vijayashree Priyadharsini Jayaseelan Paramasivam Arumugam Biomedical Research Unit and Laboratory Animal Centre-dental Research Cell Saveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamil Nadu 600077India

The biology of exosomes is a fascinating field of science that has attracted much attention from clinical researchers due to the plethora of associated *** biological cargoes serve as a hub of information about the health status of a cell or a group of *** reports on exosome-derived biomolecules in relation to diseases such as cancer,neurodegenerative diseases,and infectious diseases have spurred interest in exploring their role in the pathogenesis of other debilitating disease *** research into autoimmune disorders(ADs)in relation to exosome biology has identified novel therapeutic leads aiming to improve the life expectancy of individuals suffering from such disorders.1 One such important,notable contribution was recently shared by Guay et *** provided concreate evidence on the mechanism ofβcell apoptosis induced by the transfer of exosomal miRNAs derived from T cells,which eventually leads to type I diabetes *** crucial mediators of the process were T-lymphocyte-derived exosomes harboring miR-142-3p,miR-142-5p,and ***-miRs designed to block the interactions of miRNAs with their target genes insideβcells prevented the process of apoptosis,eventually rescuingβcells.2 Thus,targeting the mediators of crosstalk or blocking the function of exosomal miRNAs could serve as an interesting therapeutic strategy for type I diabetes mellitus(Fig.1).Consistent with the above report,this review highlights the contribution of exosomes to the development of autoimmune *** addition,this review also reveals the possible“theranostic”markers(therapeutic and diagnostic biomarkers)associated with ADs.

关键词： disorders autoimmune eventually

Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 333-345页

作者： Karthik Shree Harini Devaraj Ezhilarasan Department of Pharmacology Molecular Medicine and Toxicology LabSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiTamil Nadu 600077India

Nonalcoholic fatty liver disease(NAFLD)is a global health concern associated with significant morbidity and *** is a spectrum of diseases originating from simple steatosis,progressing through nonalcoholic steatohepatitis(NASH),fibrosis,and cirrhosis that may lead to hepatocellular carcinoma(HCC).The pathogenesis of NAFLD is mediated by the triglyceride accumulation followed by proinflam-matory cytokines expression leading to inflammation,oxidative stress,and mitochondrial dysfunction de-noted as“two-hit hypothesis”,advancing with a“third hit”of insufficient hepatocyte proliferation,lead-ing to the increase in hepatic progenitor cells contributing to fibrosis and ***/β-catenin signaling is responsible for normal liver development,regeneration,hepatic metabolic zonation,ammonia and drug detoxification,hepatobiliary development,etc.,maintaining the overall liver *** key regula-tors of canonical Wnt signaling such as LRP6,Wnt1,Wnt3a,β-catenin,GSK-3β,and APC are abnormally regulated in *** experimental studies have shown the aberrated Wnt/β-catenin signaling dur-ing the NAFLD progression and NASH to hepatic fibrosis and ***,in this review,we have em-phasized the role of Wnt/β-catenin signaling and its modulators that can potentially aid in the inhibition of NAFLD.

关键词： Steatosis Fatty liver Oxidative stress Chronic liver diseases Fibrosis Wnt/β-catenin

dental pulp stem cells and banking of teeth as a lifesaving therapeutic vista

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BIOCELL 2023年第1期47卷 71-80页

作者： SUKUMARAN ANIL RAMYA RAMADOSS NEBU GTHOMAS JASMIN MGEORGE VISHNUPRIYA KSWEETY Oral Health Institute Department of DentistryHamad Medical CorporationDohaQatar college of dental Medicine Qatar UniversityDohaQatar saveetha dental college Saveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiIndia Pushpagiri college of dental Sciences MedicityPerumthuruthyIndia

Exfoliated deciduous or an extracted healthy adult tooth can be used to harvest,process,and cryogenically preserve dental pulp stem *** stem cell-based regenerative medicine methods could benefit significantly from these mesenchymal stem *** serve as a substantial source of mesenchymal stem cells,otherwise disposed of as medical *** should be taken to store this treasure trove of stem *** responsibility of patients,dentists,and physicians is necessary to ensure that this valuable resource is not wasted and that every possible dental pulp stem cell is available for use in the *** dental pulp stem cells(DPSC)inside teeth represent a significant future source of stem cells for regenerative medicine *** review describes the ontogeny,the laboratory processing and collection,and isolation methods of *** review also discusses currently available stem cell banking facilities and their potential use in regenerative medicine procedures in dental and general medical applications in the future.

关键词： dental stem cell Stem cell therapy Differentiation Regeneration Tissue engineering Tooth banking

Advancing engineered approaches for sustainable wound regeneration and repair:Harnessing the potential of green synthesized silver nanoparticles

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Engineered Regeneration 2024年第3期5卷 306-325页

作者： J.Nandhini E.Karthikeyan E.Elizabeth Rani V.S.Karthikha D.Sakthi Sanjana H.Jeevitha S.Rajeshkumar Vijayan Venugopal A.Priyadharshan Department of Pharmaceutics Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India Department of Pharmaceutical Chemistry Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India Department of Pharmacology Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesChennaiIndia Department of Pharmaceutics School of PharmacySri Balaji Vidyapeeth(Deemed to be university)PuducherryIndia Department of conservative Dentistry and Endodontics Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia

Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and ***’s been a growing interest in exploring sustainable wound healing strategies in recent *** review examines the use of green-synthesized silver nanoparticles(AgNPs)in sustainable wound healing *** highlights the need for innovative approaches and the challenges posed by *** current wound therapies and treatments,highlighting gaps in existing methodologies,are *** review provides a com-prehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of *** properties and characterization of AgNPs are elucidated,providing insights into their *** biocompati-bility of AgNPs in wound healing is also explored,emphasizing safety in medical *** synthesized AgNPs incorporated wound dressings are detailed,showcasing their potential in clinical *** and future perspectives are discussed,addressing hurdles to widespread *** conclusion consolidates key findings,offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.

关键词： Green synthesis Wound healing AgNPs Wound healing mechanism Eco-friendly synthesis

Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 315-322页

作者： Devaraj Ezhilarasan Department of Pharmacology the Blue LabMolecular Medicine and Toxicology DivisionSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077Tamil NaduIndia

Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are less fibrogenic, migratory, and also have less proliferative potential. However, activated HSCs(a HSCs) are more fibrogenic and have a high migratory and proliferative MFBs phenotype. HSCs activation is a highly energetic process that needs abundant intracellular energy in the form of adenosine triphosphate(ATP) for the synthesis of extracellular matrix(ECM) in the injured liver to substantiate the injury. Data sources: The articles were collected through Pub Med and EMBASE using search terms "mitochondria and hepatic stellate cells", "mitochondria and HSCs", "mitochondria and hepatic fibrosis", "mitochondria and liver diseases", and "mitochondria and chronic liver disease", and relevant publications published before September 31, 2020 were included in this review. Results: Mitochondria homeostasis is affected during HSCs activation. Mitochondria in a HSCs are highly energetic and are in a high metabolically active state exhibiting increased activity such as glycolysis and respiration. a HSCs have high glycolytic enzymes expression and glycolytic activity induced by Hedgehog(Hh) signaling from injured hepatocytes. Increased glycolysis and aerobic glycolysis(Warburg effect) endproducts in a HSCs consequently activate the ECM-related gene expressions. Increased Hh signaling from injured hepatocytes downregulates peroxisome proliferator-activated receptor-γ expression and decreases lipogenesis in a HSCs. Glutaminolysis and tricarboxylic acid cycle liberate ATPs that fuel HSCs to proliferate and produce ECM during their activation. Conclusions: Available studies suggest that mitochondria functions can increase in parallel with HSCs activation. Therefore, mitochondrial modulators should be tested in an elaborate manner to control or prevent the HSCs activation

关键词： Hepatic stellate cells Glutaminolysis Glycolysis Hedgehog Myofibroblasts

Critical role of estrogen in the progression of chronic liver diseases

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 429-434页

作者： Devaraj Ezhilarasan Department of Pharmacology Biomedical Research Unit and Laboratory Animal CentreSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077Tamil NaduIndia

Background:Estrogens regulate sexual function and also have a significant role in various pathophysiological *** have a non-reproductive role as the modulators of the immune system,growth,neuronal function,and *** receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic *** purpose of the current review is to discuss the disparity role of estrogens on several forms of liver *** sources:A comprehensive search in PubMed and EMBASE was conducted using the keywords“estrogens and liver diseases”,“estradiol and liver diseases”,“hormones and liver diseases”,“endocrine function in liver diseases”,and“female hormones in liver diseases”.Relevant papers published before September 30,2019 were ***:The present review confirms the imperative role of estrogen in various forms of chronic liver *** play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal *** contrast,clinical studies also showed increased estrogen levels with chronic liver ***:Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat ***,in a few clinical studies,increased estrogen levels are also implicated in chronic liver ***,further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases.

关键词： Estrogen Hepatic fibrosis Chronic liver diseases Hepatic stellate cells