Dissecting the theranostic potential of exosomes in autoimmune disorders
作者机构：Biomedical Research Unit and Laboratory Animal Centre-Dental Research CellSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamil Nadu 600077India
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2019年第16卷第12期
页 面：935-936页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
主 题：disorders autoimmune eventually
摘 要：The biology of exosomes is a fascinating field of science that has attracted much attention from clinical researchers due to the plethora of associated *** biological cargoes serve as a hub of information about the health status of a cell or a group of *** reports on exosome-derived biomolecules in relation to diseases such as cancer,neurodegenerative diseases,and infectious diseases have spurred interest in exploring their role in the pathogenesis of other debilitating disease *** research into autoimmune disorders(ADs)in relation to exosome biology has identified novel therapeutic leads aiming to improve the life expectancy of individuals suffering from such disorders.1 One such important,notable contribution was recently shared by Guay et *** provided concreate evidence on the mechanism ofβcell apoptosis induced by the transfer of exosomal miRNAs derived from T cells,which eventually leads to type I diabetes *** crucial mediators of the process were T-lymphocyte-derived exosomes harboring miR-142-3p,miR-142-5p,and ***-miRs designed to block the interactions of miRNAs with their target genes insideβcells prevented the process of apoptosis,eventually rescuingβcells.2 Thus,targeting the mediators of crosstalk or blocking the function of exosomal miRNAs could serve as an interesting therapeutic strategy for type I diabetes mellitus(Fig.1).Consistent with the above report,this review highlights the contribution of exosomes to the development of autoimmune *** addition,this review also reveals the possible“theranosticmarkers(therapeutic and diagnostic biomarkers)associated with ADs.
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