Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases

作     者：Karthik Shree Harini Devaraj Ezhilarasan Karthik Shree Harini;Devaraj Ezhilarasan

作者机构：Department of PharmacologyMolecular Medicine and Toxicology LabSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiTamil Nadu 600077India 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2023年第22卷第4期

页      面：333-345页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a grant from the Extramural Re-search Project Indian Council of Medical Research New Delhi In-dia(58/30/2020/PHA/BMS dtd 9.11.2021) 

主　　题：Steatosis Fatty liver Oxidative stress Chronic liver diseases Fibrosis Wnt/β-catenin 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is a global health concern associated with significant morbidity and *** is a spectrum of diseases originating from simple steatosis,progressing through nonalcoholic steatohepatitis(NASH),fibrosis,and cirrhosis that may lead to hepatocellular carcinoma(HCC).The pathogenesis of NAFLD is mediated by the triglyceride accumulation followed by proinflam-matory cytokines expression leading to inflammation,oxidative stress,and mitochondrial dysfunction de-noted as“two-hit hypothesis,advancing with a“third hitof insufficient hepatocyte proliferation,lead-ing to the increase in hepatic progenitor cells contributing to fibrosis and ***/β-catenin signaling is responsible for normal liver development,regeneration,hepatic metabolic zonation,ammonia and drug detoxification,hepatobiliary development,etc.,maintaining the overall liver *** key regula-tors of canonical Wnt signaling such as LRP6,Wnt1,Wnt3a,β-catenin,GSK-3β,and APC are abnormally regulated in *** experimental studies have shown the aberrated Wnt/β-catenin signaling dur-ing the NAFLD progression and NASH to hepatic fibrosis and ***,in this review,we have em-phasized the role of Wnt/β-catenin signaling and its modulators that can potentially aid in the inhibition of NAFLD.