Fabrication of chitosan/silica hybrid coating on AZ31 Mg alloy for orthopaedic applications

作     者：M.Kalaiyarasan S.Pugalmani N.Rajendran 

作者机构：Department of ChemistryCEG CampusAnna UniversityChennai600025Tamil NaduIndia Department of OrthodonticsSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical ScienceSaveetha UniversityChennai-600077India 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2023年第11卷第2期

页      面：614-628页

核心收录：

学科分类：0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：Basic Scientific Research UGC-DRS Department of Science and Technology, Ministry of Science and Technology, India, डीएसटी University Grants Commission, UGC 

主　　题：AZ31 Mg alloy Chitosan/silica Hemocompatibility MTT assay and antibacterial Studies 

摘      要：Biocompatible conversion of chitosan and chitosan/silica hybrid coating were prepared to enhance the biocompatibility and corrosion resistance of biodegradable AZ31 Mg alloy. The coatings were optimized and analysed with potentiodynamic polarization, SEM, ATR-IR and XPS studies. Potentiodynamic polarization studies, revealed that the coatings exhibited high corrosion resistance. The surface morphology of the Ch-3/Si coating showed small globular rough structure. The presence of functional groups was confirmed by ATR-IR. For a better understanding of chitosan/silica hybrid coating, the chemical states were examined by XPS studies. The in-vitro bioactivity of the coated samples was evaluated in Earle’s solution, which formed a dense layer of coral-like structure and calcium-deficient apatite with less stoichiometric ratio than the hydroxyapatite. In-vitro cell culture studies exhibited a good cell proliferation rate and the fabricated Ch-3/Si coating was found to be non-hemolytic. The bacterial studies proved that Ch-3/Si coating possessed inherent antibacterial activity.