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Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters

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Journal of Bionic Engineering 2024年第2期21卷 866-876页

作者： Sina Khajei Abed Khorasani Mohammad Reza Afarinesh Vahid Sheibani Neuroscience research center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran Cognitive Neuroscience research center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran

In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from *** to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first *** a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the *** results showed reductions in responses to stimulation over ***,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from *** was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed *** negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,*** MS-CPP coefficients of determination(R-squared)were also between 0.76 and *** addition,the MS-NP coefficients of determination were between 0.63 and ***,it is concluded that the electrical stimulation parameters influence the behavioral outcomes ***,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关键词： Periaqueductal Gray(PAG) Navigation Ratbot Animal-robot Forward locomotion Movement slope

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Tuning electrochemical water activation over NiIr single-atom alloy aerogels for stable electrochemiluminescence

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Science Bulletin 2024年第15期69卷 2387-2394页

作者： Ling Ling Mengzhen Xi Hengjia Wang Runshi Xiao Lirong Zheng Liuyong Hu Wenling Gu Chengzhou Zhu State Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Hubei Key Laboratory of plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsWuhan Institute of TechnologyWuhan 430205China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The anodic oxygen evolution reaction is a well-acknowledged side reaction in traditional aqueous electrochemiluminescence(ECL) systems due to the generation and surface aggregation of oxygen at the electrode, which detrimentally impacts the stability and efficiency of ECL emission. However, the effect of reactive oxygen species generated during water oxidation on ECL luminophores has been largely overlooked. Taking the typical luminol emitter as an example, herein, we employed NiIr single-atom alloy aerogels possessing efficient water oxidation activity as a prototype co-reaction accelerator to elucidate the relationship between ECL behavior and water oxidation reaction kinetics for the first time. By regulating the concentration of hydroxide ions in the electrolyte, the electrochemical oxidation processes of both luminol and water are finely tuned. When the concentration of hydroxide ions in electrolyte is low,the kinetics of water oxidation is attenuated, which limits the generation of oxygen, effectively mitigates the influence of oxygen accumulation on the ECL strength, and offers a novel perspective for harnessing side reactions in ECL systems. Finally, a sensitive and stable sensor for antioxidant detection was constructed and applied to the practical sample detection.

关键词： Electrochemiluminescence Luminol Water activation Single-atom doping Sensing

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Lattice Boltzmann simulation study of anode degradation in solid oxide fuel cells during the initial aging process

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 405-411页

作者： Shixue Liu Zhijing Liu Shuxing Zhang Hao Wu Hydrogen Energy Industrial technology Innovation center China Nuclear Power Technology Research InstituteShenzhen 518031China Shenzhen Engineering research center for Hydrogen Safety Shenzhen 518031China

For present solid oxide fuel cells(SOFCs),rapid performance degradation is observed in the initial aging process,and the dis-cussion of the degradation mechanism necessitates quantitative ***,focused ion beam-scanning electron microscopy was em-ployed to characterize and reconstruct the ceramic microstructures of SOFC *** lattice Boltzmann method(LBM)simulation of multiphysical and electrochemical processes in the reconstructed models was *** samples collected from industrial-size cells were characterized,including a reduced reference cell and a cell with an initial aging *** parameters of the reconstructed microstructures revealed a significant decrease in the active triple-phase boundary and Ni connectivity in the aged cell compared with the reference *** LBM simulation revealed that activity degradation is dominant compared with microstructural degradation during the initial aging process,and the electrochemical reactions spread to the support layer in the aged *** microstructural and activity de-gradations are attributed to Ni migration and coarsening.

关键词： solid oxide fuel cell anode degradation focused ion beam-scanning electron microscopy lattice Boltzmann method

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Cognitive impairment in cerebral small vessel disease induced by hypertension

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Neural Regeneration research 2024年第7期19卷 1454-1462页

作者： Weipeng Wei Denglei Ma Lin Li Lan Zhang Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Geriatric medical research center Beijing Engineering Research Center for Nervous System DrugsNational Center for Neurological DisordersNational Clinical Research Center for Geriatric DiseasesBeijingChina

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular *** r,the causal relationship between hypertension and cerebral small vessel disease remains *** has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular *** hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and *** is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of *** review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive *** also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

关键词： blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter high signal intensity

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Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis

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Journal of Environmental Sciences 2024年第7期141卷 139-150页

作者： Shahrzad Molavinia Dian Dayer Mohammad Javad Khodayar Gholamreza Goudarzi Maryam Salehcheh Cellular and Molecular research center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Toxicology School of PharmacyAhvaz Jundishapur University of Medical SciencesAhvazIran Student research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Toxicology research center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Air Pollution and Respiratory Diseases research center Ahvaz Jundishapur University of Medical SciencesAhvazIran Iranian Scientific Association of Clean Air TehranIran

Epidemiological evidence presents that dust storms are related to respiratory diseases,such as pulmonary fibrosis(PF).However,the precise underlying mechanisms of SPM-elicited adverse effects still need to be ***-mesenchymal transition(EMT)process is a characteristic of *** discussed whether suspended particulate matter(SPM)is involved in EMT induction via transforming growth factor-β1(TGF-β1).In this study,a detailed elemental analysis(55 elements),particle size,and morphology were *** investigate the toxicity of SPM,an MTT test was performed to detect cell ***,A549cells were exposed to selected concentrations of SPM(20 and 40μg/mL)for single and repeated *** DCFH-DA assay showed that exposure to SPM could produce reactive oxygen species(ROS).The ELISA assay demonstrated increased levels of interleukin-8(IL-8)and TGF-β1 in the *** blot was used to detect the expression of proteins associated with EMT and the SMAD3-dependent *** of western blot demonstrated that E-cadherin was reduced,whereas p-SMAD3,vimentin,andα-smooth muscle actin were *** findings indicated that SPM triggered EMT by induction of oxidative stress,inflammation,and the TGF-β1/SMAD3 pathway activation.

关键词： Particulate matter TGF-β1 Oxidative stress Epithelial-mesenchymal transition Pulmonary fibrosis Cells

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An impact sensitivity assessment method of spacecraft based on virtual exterior wall

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Defence technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang Chi Yuyan Liu Diqi Hu Baojun Pang Hypervelocity Impact research center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the *** PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： Sensitivity OD/M Spacecraft Virtual exterior wall

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Control of electromechanical performance in 3D printing latticestructured BaTiO_(3) piezoelectric ceramics

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Journal of Advanced Ceramics 2024年第7期13卷 987-1001页

作者： Zhujun Jiang Yinghong Sun Jimin Chen Yong Zeng Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Beijing Engineering research center of 3D Printing for Digital medical Health Beijing University of TechnologyBeijing 100124China

Barium titanate(BaTiO_(3))piezoelectric ceramics with triply periodic minimal surface(TPMS)structures have been frequently used in filters,engines,artificial bones,and other fields due to their high specific surface area,high thermal stability,and good heat ***,only a limited number of studies have analyzed the effect of various parameters,such as different wall thicknesses and porosities of TPMS structures,on ceramic electromechanical *** this study,we first employed vat photopolymerization(VPP)three-dimensional(3D)printing technology to fabricate high-performance BaTiO_(3) *** investigated the slurry composition design and forming process and designed a stepwise sintering postprocessing technique to achieve a density of 96.3%and a compressive strength of 250±25 MPa,with the piezoelectric coefficient(d33)reaching 263 pC/***,we explored the influence of three TPMS structures,namely,diamond,gyroid,and Schwarz P,on the piezoelectric and mechanical properties of BaTiO_(3) ceramics,with the gyroid structure identified as exhibiting optimal ***,we examined the piezoelectric and mechanical properties of BaTiO_(3) ceramics with the gyroid structure of varying wall thicknesses and porosities,thus enabling the modulation of ceramic electromechanical performance.

关键词： three-dimensional(3D)printing piezoelectric ceramics porous structure mechanical properties electrical properties

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Virtual source approach for maximizing resolution in high-penetration gamma-ray imaging

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Matter and Radiation at Extremes 2024年第3期9卷 19-30页

作者： Yuchi Wu Shaoyi Wang Bin Zhu Yonghong Yan Minghai Yu Gang Li Xiaohui Zhang Yue Yang Fang Tan Feng Lu Bi Bi Xiaoqin Mao Zhonghai Wang Zongqing Zhao Jingqin Su Weimin Zhou Yuqiu Gu National Key Laboratory of plasma Physics Laser Fusion Research CenterCAEPMianyangSichuan 621900China College of Physics Sichuan UniversityChengdu 610065China

High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various *** high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray *** conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung *** size of the gamma-ray source is dependent on the dimensional characteristics of the electron *** research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in *** our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial *** this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission *** the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission *** optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm.

关键词： resolution approach utilizing

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Influence of syngas components and ash particles on the radiative heat transfer in a radiant syngas cooler

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Chinese Journal of Chemical Engineering 2024年第4期68卷 203-215页

作者： Chen Han Youmin Situ Huaxing Zhu Jianliang Xu Zhenghua Dai Guangsuo Yu Haifeng Liu National Energy Coal Gasification technology research and Development center East China University of Science and TechnologyShanghai 200237China Shanghai Engineering research center of Coal Gasification East China University of Science and TechnologyShanghai 200237China

Radiant syngas cooler(RSC)is widely used as a waste heat recovery equipment in industrial *** this work,an RSC with radiation screens is established and the impact of gaseous radiative property models,gas components,and ash particles on heat transfer is investigated by the numerical simulation *** the syngas components and the pressure environment of the RSC,a modified weighted-sum-of-gray-gases model was *** modified model shows high accuracy in *** computational fluid dynamics simulation,the calculated steam production is only 0.63%in error with the industrial *** with Smith's model,the temperature decay along the axial direction calculated by the modified model is *** components are of great significance to heat recovery capacity,especially when the absorbing gas fraction is less than 10%.After considering the influence of particles,the outlet temperature and the proportion of radiative heat transfer are less affected,but the difference in steam output reaches 2.7 t·h^(-1).The particle deposition on the wall greatly reduces the heat recovery performance of an RSC.

关键词： Radiant syngas cooler Weighted-sum-of-gray-gases model Numerical simulation Particle radiation

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Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

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Current medical Science 2024年第3期44卷 642-647页

作者： Wan-rong LU Ping WU Gong SONG Mei-qi GU Zhe XU Li HE National Clinical research center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,P<0.001),third trimester trauma(OR=3.878,95%CI:1.343–11.204,P=0.012),abdominal pain(OR=3.032,95%CI:1.221–7.527,P=0.017),vaginal bleeding(OR=3.226,95%CI:1.093–9.523,P=0.034),positive scan in focused assessment with sonography for trauma(FAST)positive(OR=8.496,95%CI:2.825–25.555,P<0.001),9≤injury severity score(ISS)<16(OR=3.039,95%CI:1.046–8.835,P=0.041)and ISS≥16(OR=5.553,95%CI:1.387–22.225,P=0.015)increased the probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

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