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Holomorphic Retractions of Bounded Symmetric Domains onto Totally Geodesic Complex Submanifolds

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Chinese Annals of Mathematics,Series B 2022年第6期43卷 1125-1142页

作者： Ngaiming MOK Department of Mathematics The University of Hong KongPokfulam RoadHong Kong

Given a bounded symmetric domain Ω the author considers the geometry of its totally geodesic complex submanifolds S■Ω.In terms of the Harish-Chandra realization Ω and taking S to pass through the origin 0∈Ω,so that S=E∩Ω for some complex vector subspace of C^(n),the author shows that the orthogonal projectionρ:Ω→E maps Ω onto S,and deduces that S■Ω is a holomorphic isometry with respect to the Caratheodory *** first theorem gives a new derivation of a result of Yeung’s deduced from the classification theory by Satake and Ihara in the special case of totally geodesic complex submanifolds of rank 1 and of complex dimension≥2 in the Siegel upper half plane Hg,a result which was crucial for proving the nonexistence of totally geodesic complex sub or bifolds of dimension≥2 on the open Torelli locus of the Siegel modular variety Ag by the same *** proof relies on the characterization of totally geodesic submanifolds of Riemannian symmetric spaces in terms of Lie triple systems and a variant of the Hermann Convexity Theorem giving a new characterization of the Harish-Chandra realization in terms of bisectional curvatures.

关键词： Bounded symmetric domain Harish-Chandra embedding Holomorphic retraction Totally geodesy

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

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Cellular & Molecular Immunology 2022年第5期19卷 588-601页

作者： Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong21 Sassoon RoadPokfulamHong KongChina

Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to ***,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point *** virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission *** also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse *** neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 *** immunoglobulin A was detected in the blood and nasal wash of vaccinated *** work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy.

关键词： Live attenuated vaccine NSP16 2'-O-methyltransferase T-cell response Mucosal immunity Sterilizing immunity

Laser Induced Fluorescence Spectroscopy of IrN

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Chinese Journal of Chemical Physics 2009年第2期22卷 157-161页

作者： H. F. Pang A. S. C. Cheung Department of Chemistry The University of Hong Kong Pokfulam Road Hone Kong China

High resolution laser induced fluorescence, spectra of IrN in the spectral region between 394 and 520 nm were recorded using laser vaporization/reaction free jet expansion and laser induced fluorescence spectroscopy. Seven new vibronic transition bands were observed and analyzed. Two Ω=1 and five Ω=0 new states were identified. Least squares fit of rotationally resolved transition lines yielded accurate molecular constants for the upper states. Spectra of isotopic molecules were observed, which provided confirmation for the vibrational assignment. Comparison of the observed electronic states of IrB, IrC, and IrN provides a good understanding of the chemical bonding of this group of molecules.

关键词： Electronic transition Rotational analysis Iridium mononitride Laser induced fluorescence spectroscopy

Synthesis and thermal conductivity of microfluidic copper nanofluids

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Particuology 2010年第3期8卷 262-271页

作者： Xiaohao Wei Liqiu Wang Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong China

A microfluidic chemical solution method is developed for the synthesizing Cu nanofluids. The method replaces batch-based macroreactors in the conventional chemical solution method by continuous-flow microfluidic microreactors, thereby enabling the synthesis of nanofluids with various microstructures. The Cu nanofluids synthesized by this technology show a better stability, remaining stable even after more than 100 h standing. The measured thermal conductivity shows that the presence of nanoparticles can either upgrade or downgrade fluid conductivity, a phenomenon predicted by the recent thermal-wave theory of nanofluids.

关键词： Nanofluids Heat conduction Thermal conductivity Synthesis

Oil-mediated high-throughput generation and sorting of water-in-water droplets

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Microsystems & Nanoengineering 2020年第1期6卷 484-493页

作者： Lang Nan Yang Cao Shuai Yuan Ho Cheung Shum Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongChina Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongChina

Aqueous two-phase system(ATPS)droplets have demonstrated superior compatibility over conventional water-in-oil droplets for various biological ***,the ultralow interfacial tension hampers efficient and stable droplet generation,limiting further development and more extensive use of such ***,we present a simple strategy to employ oil as a transient medium for ATPS droplet *** methods based on passive flow focusing and active pico-injection are demonstrated to generate water-water-oil double emulsions,achieving a high generation frequency of~2.4 *** evaporation of the oil to break the double emulsions,the aqueous core can be released to form uniform-sized water-in-water ***,this technique can be used to fabricate aqueous microgels,and the introduction of the oil medium enables integration of droplet sorting to produce single-cell-laden hydrogels with a harvest rate of over 90%.We believe that the demonstrated high-throughput generation and sorting of ATPS droplets represent an important tool to advance droplet-based tissue engineering and single-cell analyses.

关键词： limiting sized compatibility

Quantum transport in topological semimetals under magnetic fields

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Frontiers of physics 2017年第3期12卷 43-60页

作者： Hai-Zhou Lu Shun-Qing Shen Department of Physics The University of Hong Kong Pokfulam Road Hong Kong China

Topological semimetals are three-dimensional topological states of matter, in which the conduction and valence bands touch at a finite number of points, i.e., the Weyl nodes. Topological semimetals host paired monopoles and antimonopoles of Berry curvature at the Weyl nodes and topologically protected Fermi arcs at certain surfaces. We review our recent works on quantum transport in topo- logical semimetals, according to the strength of the magnetic field. At weak magnetic fields, there are competitions between the positive magnetoresistivity induced by the weak anti-localization effect and negative magnetoresistivity related to the nontrivial Berry curvature. We propose a fitting formula for the magnetoconductivity of the weak anti-localization. We expect that the weak localization may be induced by inter-valley effects and interaction effect, and occur in double-Weyl semimetals. For the negative magnetoresistance induced by the nontrivial Berry curvature in topological semimetals, we show the dependence of the negative magnetoresistance on the carrier density. At strong magnetic fields, specifically, in the quantum limit, the magnetoconductivity depends on the type and range of the scattering potential of disorder. The high-field positive magnetoconductivity nmy not be a com- pelling signature of the chiral anomaly. For long-range Gaussian scattering potential and half filling, the magnetoconductivity can be linear in the quantum limit. A minimal conductivity is found at the Weyl nodes although the density of states vanishes there.

关键词： topological semimetal magnetoconductivity magnetoresistance localization,anti-localization chiral anomaly

Design, Synthesis, Photophysical Studies and Electrochemistry of Carbazole-, Oxadiazole-, and Oxadiazole-Triarylamine-Containing Rhenium(Ⅰ) Diimine Alkynyl Complexes

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Chinese Journal of Chemistry 2014年第10期32卷 1015-1021页

作者： Wai-Kin Chung Keith Man-Chung Wong Vivian Wing-Wah Yam and Department of ChemistryThe University of Hong KongPokfulam RoadHong KongChina

A series of rhenium(I)diimine alkynyl complexes with various electron-and hole-transporting moieties has been synthesized and *** electronic absorption,emission and electrochemical properties have also been studied.

关键词： electrochemistry luminescence metal alkynyl rhenium(Ⅰ)diimine,UV/Vis spectroscopy

Prevention of recurrent hepatitis B infection after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 465-472页

作者： Tiffany CL Wong James YY Fung Chung Mau Lo Department of Surgery Queen Mary Hospital The University of Hong Kong102 Pokfulam Road Department of Medicine Queen Mary Hospital The University of Hong Kong102 Pokfulam Road

BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term *** purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant *** SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were ***:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and *** the development of newer and stronger antiviral agents,the need for life-long HBIG is *** their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent ***:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation.

关键词： hepatitis B liver transplantation hepatitis B immune globulin antiviral therapy adoptive immunity transfer HBV vaccination

Electrospun multifunctional tissue engineering scaffolds

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Frontiers of Materials Science 2014年第1期8卷 3-19页

作者： Chong WANG Min WANG Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong China

Tissue engineering holds great promises in providing successful treat- ments of human body tissue loss that current methods are unable to treat or unable to achieve satisfactory clinical outcomes. In scaffold-based tissue engineering, a high- performance scaffold underpins the success of a tissue engineering strategy and a major direction in the field is to create multifunctional tissue engineering scaffolds for enhanced biological performance and for regenerating complex body tissues. Electrospinning can produce nanofibrous scaffolds that are highly desirable for tissue engineering. The enormous interest in electrospinning and electrospun fibrous structures by the science, engineering and medical communities has led to various developments of the electrospinning technology and wide investigations of eiectrospun products in many industries, including biomedical engineering, over the past two decades. It is now possible to create novel, multicomponent tissue engineering scaffolds with multiple functions. This article provides a concise review of recant advances in the R ＆ D of electrospun multifunctional tissue engineering scaffolds. It also presents our philosophy and research in the designing and fabrication of electrospun multicomponent scaffolds with multiple functions.

关键词： electrospinning monocomponent multicomponent scaffold corHhell drug biomolecule growth factor controlled release