Prevention of recurrent hepatitis B infection after liver transplantation

作     者：Tiffany CL Wong James YY Fung Chung Mau Lo 

作者机构：Department of Surgery Queen Mary HospitalThe University of Hong Kong102 Pokfulam Road Department of Medicine Queen Mary HospitalThe University of Hong Kong102 Pokfulam Road 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2013年第12卷第5期

页      面：465-472页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：hepatitis B liver transplantation hepatitis B immune globulin antiviral therapy adoptive immunity transfer HBV vaccination 

摘      要：BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term *** purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant *** SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were ***:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and *** the development of newer and stronger antiviral agents,the need for life-long HBIG is *** their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent ***:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation.