检索结果-南通市图书馆

Alternative Exposure Parameters and Post Process Noise Reduction Expect Considerable Dose Reduction in Single Mammography Views—Initial Experience on Mastectomy Specimens

引用

Advances in breast Cancer Research 2013年第3期2卷 91-96页

作者： Adriana M. J. Bluekens Ruben Evan Engen Nico Karssemeijer Klaas H. Schuur Mireille J. M. Broeders Gerard J. den Heeten Gerard J. den Heeten Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands national expert and training centre for breast Cancer Screening Nijmegen The Netherlands St. Elisabeth Hospital Department of Radiology Tilburg The Netherlands

Objective: To experimentally indicate a lower limit of dose in mammographic imaging yielding adequate image quality for complementary diagnostic views, by evaluation of image series with different exposure parameters and additional image processing on mastectomy specimens with diverse pathology. Methods: Image series were obtained on seven specimens with different target-filter combinations at different exposure values. Three experienced radiologists assessed the lowest acceptable dose level per specimen using a relative grading technique. With the standard image as reference, fibroglandular tissue and pathological structures, including microcalcifications, were evaluated. Subsequently, a series of pixel binning processes was tested and subjectively assessed on the selected images. Results: The lowest dose level at which image quality was acceptable, and achieved with a W/Ag target-filter combination at 32 kV and 4 mAs. These images can be acquired with 10.4% to 22.4% of the average glandular dose in standard images. Post process pixel binning added to the interpretability of such low dose images. Conclusion: This specimen study suggests that dose level of mammography images might be reduced substantially by general application of a W/Ag spectrum, particularly when combined with post process noise reduction. Future studies should focus on the feasibility of this technique in clinical mammography.

关键词： Digital Mammography Dose Reduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

荷兰乳腺筛查自检系统放射科医师实践的经验教训

引用

国际医学放射学杂志 2014年第2期 193-194页

作者： J.M.H,Timmers A.L.M,Verbeek R.M,Pijnappel M.J.M,Broeders G.J.den Heeten 刘靓 national expert and training centre for breast Cancer Screening PO Box 6873 6503 GJ Nijmegen The Netherlands

目的评估荷兰推荐的国民生存质量保障工程中放射科医师乳腺筛查自检系统的应用价值。方法邀请144名放射科医师参与完成一组60例病人乳腺X线片筛查研究

关键词：乳腺筛查自检测反馈观察者间一致性乳腺X线摄影术

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment

引用

Bone Research 2019年第2期7卷 157-170页

作者： Nathalie Bock Ali Shokoohmand Thomas Kryza Joan Rohl Jonelle Meijer Phong A. Tran Colleen C. Nelson Judith A. Clements Dietmar W. Hutmacher School of Biomedical Sciences Faculty of Health and Australian Prostate Cancer Research Centre (APCRC-Q)Institute of Health and Biomedical Innovation (IHBI)Queensland University of Technology (QUT)BrisbaneQLD 4000Australia Translational Research Institute (TRI) WoolloongabbaQLD 4102Australia centre in Regenerative Medicine QUTKelvin GroveQLD 4059Australia Bone and Joint Disorders Program School of ChemistryPhysics and Mechanical EngineeringScience and Engineering Faculty (SEF)QUTBrisbaneQLD 4000Australia Australian Research Council (ARC) training centre in Additive Biomanufacturing QUTKelvin GroveQLD 4059Australia

While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly ***,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this *** model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral *** co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in ***-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic *** led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone *** showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards *** unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment.

关键词： Engineering osteoblastic metastases the adaptive response metastatic microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乳腺癌风险预测模型:基于普通乳腺X线检查结果的列线图

引用

国际医学放射学杂志 2013年第6期 593-593页

作者： J.M.H.Timmers A.L.M.Verbeek J.IntHout R.M.Pijnappel M.J.M.Broeders G.J.den Heeten 时代刘倩 national expert and training centre for breast Cancer Screening PO Box 6873 6503 GJ NijmegenThe Netherlands

摘要目的确定一项以乳腺X线筛查结果为乳腺癌的预测模型方法,建立此模型目的是在分析BI-RADS时减少阅片者间的差异性。方法回顾性分析352例进行乳腺X线

关键词：乳腺癌肿块筛查乳腺摄影决策支持技术列线图

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

乳腺数字摄影与胶片摄影筛查对于早期发现临床相关癌症的比较:多中心研究

引用

国际医学放射学杂志 2013年第1期 71-71页

作者： A.M.J.Bluekens R.Holland N.Karssemeijer M.J.M.Broeders G.J.den Heeten 柴超 national expert and training centre for breast Cancer ScreeningPO Box 68736503 GJ Nijmegenthe Netherlands

目的比较胶片摄影与数字摄影在乳腺癌筛查中对于临床相关癌症的检出率。材料与方法研究经过地区医学伦理委员会批准,不需要知情同意书。在荷兰每两年1次的筛查项目中,全国广泛使用数字乳腺摄影之前,有3个筛查区进行了数字乳腺摄影。最... 详细信息

目的比较胶片摄影与数字摄影在乳腺癌筛查中对于临床相关癌症的检出率。材料与方法研究经过地区医学伦理委员会批准,不需要知情同意书。在荷兰每两年1次的筛查项目中,全国广泛使用数字乳腺摄影之前,有3个筛查区进行了数字乳腺摄影。最初的筛查检查中,每侧乳腺进行内外侧斜位和头尾位摄影。而在随后的检查中,常规进行内外侧斜位摄影。如果有需要才进行头尾位摄影。将最初和随后的乳腺胶片摄影和数字摄影的筛查结果,包括放射学与病理学特点进行比较。结果 2003—2007年间共进行1198493例筛查,18896例进行了复查(胶片摄影:最初的筛查为2.6%,随后的检查为1.3%;数字摄影:最初的筛查为4.4%,随后的检查为2.1%;两者P<0.001)。6410例妇女诊断为乳腺癌(胶片摄影:最初的检查每1000名妇女的检出率为5.6,随后的检出率为5.2;数字摄影:最初的检查中每1000名妇女的检出率为6.8,随后的检出率6.1;P=0.02和P<0.001)。不论哪次筛查,数字乳腺摄影均可发现更多的导管原位癌。在随后的检查中,可发现更多的浸润癌,特别是伴有微钙化者(P=0.047)。两种成像方法中发现的导管原位癌和浸润癌的组织病理学分化等级是相似的。但是,在随后的检查中数字乳腺摄影能检出更多高级别的导管原位癌(P=0.013)。结论在对人群的乳腺筛查项目中,乳腺数字摄影对于导管原位癌和浸润癌的检测显著优于胶片摄影。采用数字乳腺摄影进行筛查,低级别导管原位癌的检出并没有增加的迹象,表明有可能存在过度诊断。相反的,数字乳腺摄影似乎增加了高级别导管原位癌的检测。

关键词：胶片摄影筛查乳腺乳房数字摄影癌症

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

乳腺影像报告和数据系统(BI-RADS)在荷兰的乳腺癌筛查方案中具有评估和分级工具的作用

引用

国际医学放射学杂志 2012年第5期 506-506页

作者： J.M.H.Timmers H.J.van Doorne-Nagtegaal H.M.Zonderland H.van Tinteren O.Visser A.L.M.Verbeek 梁雪 national expert and training centre for breast Cancer Screening PO Box 68736503 GJ Nijmegenthe Netherlands

摘要目的评估乳腺影像报告和数据系统(BI-RADS)在荷兰的乳腺癌筛查质量评价中的适用性。方法对阿姆斯特丹地区(2005年11月—2006年7月)93793名女性筛查的数据进行回顾性分析。从筛查登记系统得到BI-RADS分级、影像诊断、年龄、最终诊断... 详细信息

摘要目的评估乳腺影像报告和数据系统(BI-RADS)在荷兰的乳腺癌筛查质量评价中的适用性。方法对阿姆斯特丹地区(2005年11月—2006年7月)93793名女性筛查的数据进行回顾性分析。从筛查登记系统得到BI-RADS分级、影像诊断、年龄、最终诊断和最终的TNM分期。通过癌症登记系统筛查出乳腺新发癌。阿姆斯特丹地区在全国推广数字化乳腺摄影(2009—2010年)之前,作为试点采用BI-RADS。

关键词： BI-RADS 阳性预测值质量评价性能乳腺X线摄影筛查

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

数字钼靶筛查乳腺癌:对转诊率的早期和长期影响

引用

国际医学放射学杂志 2010年第6期 581-581页

作者： A.M.J.Bluekens N.Karssemeijer D.Beijerinck J.J.M.Deurenberg R.E.van Engen M.J.M.Broeders 李瑞利 national expert and training centre for breast Cancer Screening P.O.Box 68736503 GJNijmegenthe Netherlands

目的研究采用全景数字乳腺摄影(FFDM)替代传统钼靶筛查乳腺癌对转诊方式的影响。材料与方法目前全国范围的数字化中,已采用FFDM。在第一次和后续的FFDM

关键词：乳腺癌数字乳腺摄影普查转诊率训练

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer

引用

Science China(Life Sciences) 2022年第11期65卷 2205-2217页

作者： Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineBreast Tumor CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Clinical Research Design Division Clinical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Medical Statistics School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Department of breast Surgery the Second Affiliated HospitalShandong UniversityJinan 250033China Department of breast Surgery Key Laboratory of Breast DiseasesThird Hospital of NanchangNanchang 330009China Department of breast Surgery the First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Experimental and Clinical Pharmacology University of MinnesotaMinneapolisMN 55455USA Department of Surgery College of MedicineUniversity of RzeszówRzeszów 35-959Poland Department of Radiation Oncology O’Neal Comprehensive Cancer CenterUniversity of Alabama at Birmingham School of MedicineBirminghamALUSA Laboratoty of Predictive Oncology Institut Paoli-CalmettesCentre de Recherche en Cancérologie de MarseilleINSERM UMR1068CNRS UMR725MarseilleFrance Department of Drug Development and Innovation(D3i) Institut CurieParis 75005France Comprehensive Cancer Center UOC di Oncologia MedicaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy Multidisciplinary breast Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy breast Surgery Department of Surgical OncologyRoswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Surgery MD Anderson Cancer CenterHoustonTX 77030USA Department of Plastic and Reconstructive Surgery

Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,*** who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer.

关键词： hormone receptor-positive breast cancer micro RNA signature neoadjuvant chemotherapy dynamic contrast-enhanced magnetic resonance imaging nomogram

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Scientific evidence is just the starting point: A generalizable process for developing sports injury prevention interventions

引用

Journal of Sport and Health Science 2016年第3期5卷 334-341页

作者： Alex Donaldson David G.Lloyd Belinda J.Gabbe Jill Cook Warren Young Peta White Caroline F.Finch Australian centre for Research into Injury in Sport and its Prevention (ACRISP) Federation University Australia centre for Musculoskeletal Research Griffith Health Institute Griffith University Department of Epidemiology and Preventive Medicine Monash University La Trobe Sport and Exercise Medicine Research centre La Trobe University School of Health Sciences Federation University Australia

Background: The 2 most cited sports injury prevention research frameworks incorporate intervention development, yet little guidance is available in the sports science literature on how to undertake this complex process. This paper presents a generalizable process for developing implementable sports injury prevention interventions, including a case study applying the process to develop a lower limb injury prevention exercise training program(Footy First) for community Australian ***: The intervention development process is underpinned by 2 complementary premises:(1) that evidence-based practice integrates the best available scientific evidence with practitioner expertise and end user values and(2) that research evidence alone is insufficient to develop implementable ***: The generalizable 6-step intervention development process involves(1) compiling research evidence, clinical experience, and knowledge of the implementation context;(2) consulting with experts;(3) engaging with end users;(4) testing the intervention;(5) using theory; and(6)obtaining feedback from early implementers. Following each step, intervention content and presentation should be revised to ensure that the final intervention includes evidence-informed content that is likely to be adopted, properly implemented, and sustained over time by the targeted intervention deliverers. For Footy First, this process involved establishing a multidisciplinary intervention development group, conducting 2targeted literature reviews, undertaking an online expert consensus process, conducting focus groups with program end users, testing the program multiple times in different contexts, and obtaining feedback from early implementers of the ***: This systematic yet pragmatic and iterative intervention development process is potentially applicable to any injury prevention topic across all sports settings and levels. It will guide researchers wishing to undertake interventio

关键词： Australian football Implementation Intervention development Lower limb injuries Research-to-practice Sports injury prevention Translation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties： Application in simultaneous amplification-free analysis of multiple RNA species

引用

Nano Research 2018年第2期11卷 940-952页

作者： Kevin M. Koo Laura G. Carrascosa Matt Trau centre for Personalized Nanomedicine Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane Australia School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Australia

The intrinsic affinity of DNA molecules toward metallic ions can drive the specific formation of copper nanostructures within the nucleic acid helix structure in a sequence-dependent manner. The resultant nanostructures have interesting fluorescent and electrochemical properties, which are attractive for novel biosensing applications. However, the potential of using DNA-templated nano- structures for precision disease diagnosis remains unexplored. Particularly, DNA- templated nanostructures show high potential for the universal amplification-free detection of different RNA biomarker species. Because of their low cellular levels and differing species-dependent length and sequence features, simultaneous detection of different messenger RNAs, microRNAs, and long non-coding RNAs species with a single technique is challenging. Here, we report a contemporary technique for facile in situ assembly of DNA-templated copper nanoblocks （CuNBs） on various RNA species targets after hybridization-based magnetic isolation. Our approach circumvents the typical limitations associated with amplification and labeling procedures of current RNA assays. The synthesized CuNBs enabled amplification-free fM-level RNA detection with flexible fluorescence or electrochemical readouts. Furthermore, our nanosensing technique displays potential for clinical application, as demonstrated by non-invasive analysis of three diagnostic RNA biomarkers from a cohort of 10 prostate cancer patient urinary samples with 100%-concordance （quantitative reverse transcription- polymerase chain reaction （PCR） validation）. The good analytical performance and versatility of our method may be useful in both diagnostics and research fields.

关键词： prostate cancer RNA detection DNA-templated coppernanostTuctures amplification-free fluorescence detection electrochemical detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：