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Basal physiological parameters in domesticated tree shrews(Tupaia belangeri chinensis)

Zoological research 2013年第2期34卷 69-74页

作者： Jing WANG Xin-Li XU Ze-Yang DING Rong-Rong MAO Qi-Xin ZHOU Long-Bao LV Li-Ping WANG Shuang WANG Chen ZHANG Lin XU Yue-Xiong YANG Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and MemoryKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming Primate research center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Anhui UniversityHefei 230601China Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Tree Shrew Inbreeding center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational *** advantages such as simplicity of breeding,low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model *** features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human ***,basal physiological indexes of tree shrew,especially those related to human disease,have not been systematically ***,we established important basal physiological indexes of domesticated tree shrews including several factors:(1)body weight,(2)core body temperature and rhythm,(3)diet metabolism,(4)locomotor rhythm,(5)electroencephalogram,(6)glycometabolism and(7)serum and urinary hormone level and urinary cortisol *** compared the physiological parameters of domesticated tree shrew with that of rats and *** showed that(a)the core body temperature of the tree shrew was 39.59±0.05°C,which was higher than that of rats and macaques;(b)Compared with wild tree shrews,with two activity peaks,domesticated tree shrews had only one activity peak from 17:30 to 19:30;(c)Compared with rats,tree shrews had poor carbohydrate metabolism ability;and(d)Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews,which matched activity peaks in wild tree *** results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.

关键词： Domesticated tree shrew Basal physiological indexes Rhythm Glycometabolism Stress-related hormone

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of diabetes Mellitus and center for translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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Primary malignant melanoma of the esophagus successfully treated with camrelizumab:A case report and literature review

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Oncology and translational Medicine 2022年第4期8卷 201-208页

作者： Gaoyang Lin Xin Zheng Fuman Wang Daijun Xing Yufeng Cao Department of Cardiothoracic Surgery The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China Department 3 of the Cancer center The Affiliated Qingdao Hiser Hospital of Qingdao University(Qingdao Hospital of Traditional Chinese Medicine)Qingdao 266033China

An 83-year-old Chinese woman presented with a 3-month history of *** also had a history of hypertension,type 2 diabetes,fundus hemorrhage,and cataract but no history of cutaneous,ocular,or other-site *** gastrointestinal tract angiography revealed gastritis and duodenal diverticulum;thus,an endoscopic review was *** computed tomography of the chest and upper abdomen revealed the following:(1)Esophageal space-occupying lesions and mediastinal lymph node enlargement(considering the high possibility of esophageal cancer,further endoscopy was recommended)and(2)A small amount of right pleural effusion,with no significant lymph node infiltration or distant *** identified a bulge mass blocking the esophagus from 23 to 30 cm from the *** upper mass had a spherical clustering,while the lower mass significantly *** biopsy samples were obtained from the esophagus 23 and 28 cm from the *** biopsy showed proliferation of large round tumor cells and *** showed positive findings for HMB45 and MelanA;partially positive findings for S100,CK7,CK5/6,CAM5.2,LCA,P63,and TTF-1;and negative findings for *** Ki-67 positivity index was approximately 60%.Based on these findings,the patient was diagnosed with malignant esophageal melanoma with enlarged mediastinal lymph *** was then treated with five cycles of camrelizumab therapy combined with chemotherapy from October 18,2019,to May 5,*** review following two courses of combination therapy revealed that the esophagus was 23-25 cm away from the incisors,and there were two continuous uplifted and beaded masses that had a smooth and black surface,with each of them having a length and diameter of approximately 1 *** of the mucosa around the lumen was observed at 40 cm from the incisors to the cardia;the dentate margin was clear;and the cardia had no *** patient then received fiv

关键词： primary malignant melanoma of the esophagus PD-1 mAb camrelizumab immunotherapy

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Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis

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Liver research 2021年第4期5卷 224-231页

作者： Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian UCLA-Olive View Internal Medicine Residency Program Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA Keck School of Medicine University of Southern CaliforniaLos AngelesCAUSA Department of Surgery David Geffen School of Medicine at UCLALos AngelesCAUSA Vatche and Tamar Manoukian Division of Digestive Diseases David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA

Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance *** aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained *** logistic regression was used to identify predictors of ERCP-confirmed *** were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to ***:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed *** regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed *** the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,*** high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD di

关键词： Machine learning models(MLMs) Endoscopic retrograde cholangiopancreatography(ERCP) Noninvasive imaging Bile duct disorders Common bile duct stones Gallstones

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Longitudinal assessment of liver stiffness by transient elastography for chronic hepatitis C patients

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World Journal of Clinical Cases 2022年第17期10卷 5566-5576页

作者： Anya Mezina Arunkumar Krishnan Tinsay A Woreta Kevin B Rubenstein Eric Watson Po-Hung Chen Carla Rodriguez-Watson Department of Medicine Johns Hopkins School of MedicineBaltimoreMD 21287United States Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21231United States Mid-Atlantic Permanente research Institute Kaiser Permanente Mid-Atlantic StatesRockville 20852United States Department of Health Policy and Management Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21287United States Innovation in Medical Evidence Development and Surveillance(IMEDS)Program Reagan-Udall Foundation for the FDAWashington20036United States

BACKGROUND Liver fibrosis is a common pathway of liver injury and is a feature of most chronic liver *** progression varies markedly in patients with hepatitis C virus(HCV).Liver stiffness has been recommended as a parameter of fibrosis progression/regression in patients with *** To investigate changes in liver stiffness measured by transient elastography(TE)in a large,racially diverse cohort of United States patients with chronic hepatitis C(CHC).METHODS We evaluated the differences in liver stiffness between patients treated with direct-acting antiviral(DAA)therapy and untreated *** had≥2 TE measurements and no prior DAA *** used linear regression to measure the change in liver stiffness between first and last TE in response to treatment,controlling for age,sex,race,diabetes,smoking status,human immunodeficiency virus status,baseline alanine aminotransferase,and baseline liver *** regression models analyzed the change in liver stiffness as measured by kPa,stratified by cirrhosis *** Of 813 patients,419(52%)initiated DAA *** liver stiffness was 12 kPa in 127(16%).Median time between first and last TE was 11.7 and 12.7 mo among treated and untreated patients,*** was no significant change in liver stiffness observed over time in either the group initiating DAA treatment(0.016 kPa/month;CI:-0.051,0.084)or in the untreated group(0.001 kPa/mo;CI:-0.090,0.092),controlling for covariates.A higher baseline kPa score was independently associated with decreased liver *** DAA treatment was not associated with a differential change in liver stiffness over time in patients with CHC compared to untreated patients.

关键词： Chronic hepatitis C Liver stiffness Cirrhosis Transient elastography Direct-acting antiviral therapy

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Sotagliflozin in Patients with diabetes and Chronic Kidney Disease

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四川生理科学杂志 2020年第4期42卷 391-391页

作者： Deepak L Bhatt From Brigham and Women’s Hospital Heart and Vascular center and Harvard Medical School Boston (D.L.B. C.P.C. B.M.S.) Colorado Prevention center Clinical research and Department of Medicine Division of Cardiovascular Medicine University of Colorado Anschutz Medical Campus Aurora (M.S.) the State University of New York Downstate School of Public Health Brooklyn (M.S.) the University of michigan Ann Arbor (B.P.) Li Ka Shing Knowledge Institute and the Division of Endocrinology and Metabolism St. Michael’s Hospital and the Departments of Medicine and Nutritional Sciences University of Toronto (L.A.L.) and the Division of Nephrology (D.Z.I.C.) and the Cardiovascular Division Department of Medicine Women’s College Hospital and Peter Munk Cardiac Centre (J.A.U.) University Health Network University of Toronto — all in Toronto the University of Texas Southwestern Medical center and Parkland Health and Hospital System Dallas (D.K.M.) and Lexicon Pharmaceuticals The Woodlands (P.L.) — both in Texas Vanderbilt University Medical center Nashville (J.B.L. J.P.D.) the Division of Endocrinology Diabetes and Clinical Nutrition Oregon Health and Science University Portland (M.C.R.) the Section of Endocrinology Yale School of Medicine New Haven CT (S.E.I.) Saint Luke’s Mid America Heart Institute University of Missouri–Kansas City Kansas City (M.N.K.) the School of Life and Health Sciences Aston University Birmingham (C.J.B.) and the Imperial Centre for Cardiovascular Disease Prevention Department of Primary Care and Public Health Imperial College London London (K.K.R.) — both in the United Kingdom the Department of Medicine Estudios Clínicos Latinoamérica Instituto Cardiovascular de Rosario Rosario Argentina (R.D.) Duke Clinical research Institute Duke University School of Medicine Durham NC (R.D.L.) and Université de Paris French Alliance for Cardiovascular Trials Assistance Publique–Hôpitaux de Paris Hôpital Bichat INSERM Unité 1148 Paris (P.G.S.).

Background:The efficacy and safety of sodium-glucose cotransporter 2 inhibitors such as sotagliflozin in preventing cardiovascular events in patients with diabetes with chronic kidney disease with or without albuminur... 详细信息

关键词： Kidney cardiovascular diabetes

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The etiology,clinical features and medical treatment of somatotroph adenomas

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Journal of translational Neuroscience 2018年第1期3卷 23-31页

作者： Hua Gao Jianhua Li Yazhuo Zhang Key Laboratory of Central Nervous System Injury research Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050 China Department of Neurosurgery Binzhou People’s Hospital Binzhou Shandong 256610 China Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Beijing Neurosurgical Institute Center of Brain Tumor Beijing Institute for Brain Disorder Capital Medical UniversityBeijing 100050 China

Somatotroph adenomas lead to hypersecretion of growth hormones(GH)and may cause mass *** with somatotroph adenomas may present with acral and soft tissue enlargement,joint pain,heart and respiratory failure,diabetes mellitus and hypertension,resulting in increased morbidity and *** diagnosis and treatment are therefore important in prolonging life and improving quality of *** studies depicted the landscape of genetic and epigenetic changes in sporadic somatotroph *** approaches are being developed for genetic testing,diagnosis and surveillance,which are helpful in early diagnosis,treatment and disease control of somatotroph *** suggest that patients with somatotroph adenomas are best treated with multidisciplinary teams composed of neuro-endocrinologists,neurosurgeons,radiation oncologists and other *** mini-review summarizes in a concise way the up-to-date discussion on the etiology,new diagnostic techniques and novel treatments of somatotroph adenomas.

关键词： somatotroph adenomas growth hormone(GH) somatic mutation apparent genetics treatment management

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Rapid identification of chronic kidney disease in electronic health record database using computable phenotype combining a common data model

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Chinese Medical Journal 2023年第7期136卷 874-876页

作者： Huai-Yu Wang Jian Du Yu Yang Hongbo Lin Beiyan Bao Guohui Ding Chao Yang Guilan Kong Luxia Zhang National Institute of Health Data Science at Peking University Beijing 100191China School of Public Health Peking UniversityBeijing 100191China Yinzhou District center for Disease Control and Prevention NingboZhejiang 315199China Renal Division Ningbo Yinzhou No.2 HospitalNingbo Urology and Nephrology HospitalNingboZhejiang 315192China School of Computer Science Shenyang Aerospace UniversityShenyangLiaoning 110136China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijingChina Advanced Institute of Information Technology Peking UniversityHangzhouZhejiang 311215China

To the Editor:Chronic kidney disease(CKD)is a global burden of the public *** global prevalence of CKD exceeded 10%while the awareness was around 10%.[1]In the era of big data,improving the identification of CKD using informatic tools is *** phenotype is proven as an efficient tool to facilitate the process of patient identification using electronic health record(EHR)data.

关键词： kidney record prevalence

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Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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Association between serum uric acid level and mortality in China

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Chinese Medical Journal 2021年第17期134卷 2073-2080页

作者： Dong-Yuan Chang Jin-Wei Wang Min Chen Lu-Xia Zhang Ming-Hui Zhao Renal Division Department of MedicinePeking University First HospitalInstitute of NephrologyPeking UniversityBeijing 100034China Key Laboratory of Renal Disease National Health Commission of the People’s Republic of ChinaBeijing 100034China Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking UniversityMinistry of EducationBeijing 100034China research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China

Background:Whether there is an association between serum uric acid(SUA)level and risk of mortality in the general population remains *** on the China National Survey of Chronic Kidney Disease linked to mortality data,a population-based cohort study was performed to investigate the association between SUA level and all-cause mortality,cardiovascular disease(CVD)mortality,and cancer mortality in ***:The survival status of participants in the cross-sectional survey was identified from January 1,2006 to December 31,*** 33,268 individuals with complete SUA data among the 47,204 participants were included in the *** determined the rates of all-cause mortality,CVD mortality,and cancer *** used Cox proportional hazards regression models to evaluate the effect of the SUA level on ***:During a total of 297,538.4 person-years of follow-up,1282 deaths *** the Cox proportional hazards regression model,the rate of all-cause mortality,CVD mortality,and cancer mortality had a U-shaped association with SUA levels only in men,whereas no significant associations were detected in *** all-cause mortality in men,the multivariable-adjusted hazard ratios(HRs)in the first,second,and fourth quartiles compared with the third quartile were 1.31(95%confidence interval[CI]1.04–1.67),1.17(95%CI 0.92–1.47),and 1.55(95%CI 1.24–1.93),*** CVD mortality,the corresponding HRs were 1.47(95%CI 1.00–2.18),1.17(95%CI 0.79–1.75),and 1.67(95%CI 1.16–2.43),*** the cancer mortality rate,only a marginally significant association was detected in the fourth quartile compared with the third quartile with an HR of 1.43(95%CI 0.99–2.08).Conclusions:The association between SUA and mortality differed by *** demonstrated a U-shaped association with SUA levels for all-cause and CVD mortalities among men in China.

关键词： Cardiovascular diseases Sex characteristics Serum uric acid China Cohort study Mortality Population-based

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