The etiology,clinical features and medical treatment of somatotroph adenomas
The etiology, clinical features and medical treatment of somatotroph adenomas作者机构：Key Laboratory of Central Nervous System Injury Research Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050 China Department of Neurosurgery Binzhou People’s Hospital Binzhou Shandong 256610 China Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Beijing Neurosurgical Institute Center of Brain Tumor Beijing Institute for Brain Disorder Capital Medical UniversityBeijing 100050 China
出 版 物：《Journal of Translational Neuroscience》 (转化神经科学电子杂志（英文）)
年 卷 期：2018年第3卷第1期
页 面：23-31页
学科分类：10[医学]
基 金：supported byBeijing Natural Science Foundation of China (7162035) Beijing High Level Program (2015-3-040) the NationalHigh Technology Research and Development Programof China (863 Program) (2015AA020504)
主 题：somatotroph adenomas growth hormone(GH) somatic mutation apparent genetics treatment management
摘 要：Somatotroph adenomas lead to hypersecretion of growth hormones(GH)and may cause mass *** with somatotroph adenomas may present with acral and soft tissue enlargement,joint pain,heart and respiratory failure,diabetes mellitus and hypertension,resulting in increased morbidity and *** diagnosis and treatment are therefore important in prolonging life and improving quality of *** studies depicted the landscape of genetic and epigenetic changes in sporadic somatotroph *** approaches are being developed for genetic testing,diagnosis and surveillance,which are helpful in early diagnosis,treatment and disease control of somatotroph *** suggest that patients with somatotroph adenomas are best treated with multidisciplinary teams composed of neuro-endocrinologists,neurosurgeons,radiation oncologists and other *** mini-review summarizes in a concise way the up-to-date discussion on the etiology,new diagnostic techniques and novel treatments of somatotroph adenomas.
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