Human genetic and immunological determinants of critical COVID-19 pneumonia
作者机构：St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaires Saint-Luc Brussels Belgium Institut de Recherche Expérimentale et Clinique (IREC) Université Catholique de Louvain Brussels Belgium Laboratory of Medical Genetics IRCCS Bambino Gesù Children’s Hospital Rome Italy Ankara City Hospital Yildirim Beyazit University Ankara Turkey Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL) L’Hospitalet de Llobregat Barcelona Spain Catalan Institution of Research and Advanced Studies (ICREA) Barcelona Spain Center for Biomedical Research on Rare Diseases (CIBERER) ISCIII Barcelona Spain Ankara City Hospital Ankara Turkey School of Medicine and Public Health University of Wisconsin Madison WI USA Grupo de Inmunodeficiencias Primarias Departamento de Microbiología y Parasitología Facultad de Medicina Universidad de Antioquia UDEA Medellín Colombia Research Unit Hospital Universitario Nuestra Señora de Candelaria Santa Cruz de Tenerife Spain CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III Madrid Spain Genomics Division Instituto Tecnológico y de Energías. Renovables (ITER) Santa Cruz de Tenerife Spain Department of Immunology University Hospital of Gran Canaria Dr Negrín Canarian Health System Las Palmas de Gran Canaria Spain Department of Clinical Sciences University Fernando Pessoa Canarias Las Palmas de Gran Canaria Spain Faculdades Pequeno Príncipe Instituto de Pesquisa Pelé Pequeno Príncipe Curitiba Brazil Department of Pediatrics BC Children’s and St. Paul’s Hospitals University of British Columbia Vancouver British Columbia Canada Groupe Hospitalier Pitié-Salpêtrière Paris France Department of Anatomy Physiology & Genetics Uniformed Services University of the Health Sciences Bethesda MD USA Comparative Immunology Group School of Biochemistry and Immunology Trinity Biomedical Sciences Institute Trinity College Dublin Dublin Ireland Hospital Universitari Mútua Terrassa Terrasa Spain Fundació Docència i Recerca Mutua Terrassa Terrasa Spain Universitat de Barcelona Barcelona Spain Center for Discovery and Innovation Hackensack Meridian Health Nutley NJ USA Department of Clinical Immunology and Infectious Diseases National Research Institute of Tuberculosis and Lung Diseases The Clinical Tuberculosis and Epidemiology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Masih Daneshvari Hospital Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurology Amsterdam Neuroscience Amsterdam University Medical Center University of Amsterdam Amsterdam The Netherlands Department of Medicine Division of Infectious Diseases McGill University Health Centre Montreal Quebec Canada Infectious Disease Susceptibility Program Research Institute McGill University Health Centre Montréal Québec Canada Fundacion Rioja Salud Logroño Spain Departments of Pediatrics Immunology and Microbiology University of Colorado School of Medicine Aurora CO USA Ondokuz Mayis University Samsun Turkey Pediatric Intensive Care Unit University of Health Sciences Bakirkoy Dr Sadi Konuk Research and Training Hospital Istanbul Turkey Università degli Studi di Brescia Brescia Italy Laboratory of Immunobiology Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece Department of Medicine Haukeland University Hospital Bergen Norway Immunology Research Lab Department of Pediatrics College of Medicine King Saud University Riyadh Saudi Arabia Department of Paediatric Immunology and Pulmonology Centre for Primary Immunodeficiency Ghent (CPIG) PID Research Laboratory Jeffrey Modell Diagnosis and Research Centre Ghent University Hospital Ghent Belgium Clinical Genomics IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University Milan Italy Department of Biomedicine and Prevention Tor Vergata University of Rome Rome Italy Konya City Hospital Konya Turkey CHU Kremlin-Bicêtre Paris France Department of Pediatrics Division of Pediatric Infectious Diseases Faculty of Medicine Selcuk University Konya Turkey The Genetics Institute Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA Department of Pediatric Pneumology Immunology and Intensive Care Charité Universitätsmedizin Berlin University Hospital Center Berlin Germany Department of Immunology Labor Berlin Berlin Germany Berlin Institutes of Health (BIH) Berlin-Brandenburg Center for Regenerative Therapies Berlin Germany University Hospital St Marina Varna Bulgaria Universidad de La Sabana Chia Colombia Department of Pediatrics University Hospitals Leuven Leuven Belgium Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium Laboratory for Inborn Errors of Immunity KU Leuven Leuven Belgium Center of Human Genetics Université Libre de Bruxelles (ULB) Brussels Belgium Department of Internal Medicine II Medical University of Innsbruck Innsbruck Austria School of Life Sciences Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland Precision Medicine Unit Lausanne University Hospital and University of Lausanne Lausanne Switzerland Genetics Unit Military Hospital Mohamed V Rabat Morocco IrsiCaixa IGTP CIBERINFEC UVic-UCC ICREA Barcelona Spain Murdoch Children’s Research Institute and Department of Paediatrics University of Melbourne Melbourne Victoria Australia Group of Primary Immunodeficiencies University of Antioquia Medellin Colombia Center for Autoimmune Diseases Research (CREA) School of Medicine and Health Sciences Universidad del Rosario Bogota Colombia Zukerman Mind Brain Behavior Institute Columbia University New York NY USA Centre for Precision Therapeutics Genetics & Genomic Medicine Centre NeuroGen Children’s Healthcare Holy Family Red Crescent Medical College Dhaka Bangladesh Department of Infectious Diseases and Clinical Microbiology Bakirkoy Dr Sadi Konuk Training and Research Hospital University of Health Sciences Istanbul Turkey Molecular Pathology Department of Biomedicine Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia Tokyo Medical and Dental University Tokyo Japan Centre Hospitalier Universitaire Avicenne Bobigny France University Clinic for Children’s Diseases Department of Pediatric Immunology Medical Faculty University St Cyril and Methodij Skopje North Macedonia Primary Immunodeficiency Clinical Unit and Laboratory Department of Dermatology Venereology and Dermatooncology Semmelweis University Budapest Hungary A*STAR Infectious Disease Labs Agency for Science Technology and Research Singapore Singapore Lee Kong Chian School of Medicine Nanyang Technology University Singapore Singapore Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden Human Evolutionary Genetics Unit CNRS U2000 Institut Pasteur Paris France Human Genomics and Evolution Collège de France Paris France Universidad de La Sabana Bogotá Colombia Hospital Universitario 12 de Octubre Madrid Spain ASST Spedali Civili di Brescia Brescia Italy Diabetes Center University of California San Francisco San Francisco CA USA Centre Nacional d’Anàlisi Genòmica (CNAG-CRG) Barcelona Spain Adult Immunodeficiency Unit Infectious Diseases Inflammation Center University of Helsinki and Helsinki University Hospital Helsinki Finland Rare Diseases Center and Pediatric Research Center Children’s Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland College of Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai United Arab Emirates Cellular Intelligence (Ci) Lab GenomeArc Toronto Ontario Canada Specialized Immunology Laboratory of Dr Shahrooei Ahvaz Iran Department of Microbiology and Immunology Clinical and Diagnostic Immunology KU Leuven Leuven Belgium Pediatric Infectious Diseases Unit Bakirkoy Dr Sadi Konuk Training and Research Hospital University of Health Sciences Istanbul Turkey I. Horbachevsky Ternopil National Medical University Ternopil Ukraine Central European Institute of Technology & Department of Biology Faculty of Medicine Masaryk University Brno Czech Republic Necmettin Erbakan University Konya Turkey Pediatric Infectious Diseases and Immunodeficiencies Unit Vall d’Hebron Barcelona Hospital Barcelona Catalonia Spain Feinstein Institute for Medical Research Northwell Health Manhasset NY USA SciLifeLab Department Of Women’s and Children’s Health Karolinska Institutet Stockholm Sweden GHEF Marne-la-Vallée Jossigny France Assistance Publique des Hopitaux de Marseille Marseille France Clinical Allergy and Immunology Children’s Hospital of Fudan University Shanghai China Sharjah Institute of Medical Research College of Medicine University of Sharjah Sharjah United Arab Emirates Institute of Biomedical Research of IdiPAZ University Hospital La Paz Madrid Spain Instituto Nacional de Pediatria Mexico City Mexico Department of Pediatrics Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan Bursa City Hospital Bursa Turkey Necmettin Erbakan University Meram Medical Faculty Konya Turkey Faculty of Medical Sciences University Goce Delcev Štip Republic of North Macedonia de Duve Institute and Ludwig Cancer Research Brussels Belgium BC Children’s Hospital The University of British Columbia Vancouver British Columbia Canada Garvan Institute of Medical Research Darlinghurst New South Wales Australia St Vincent’s Clinical School Faculty of Medicine UNSW Sydney Syndey New South Wales Australia Department of Molecular Biology and Genetics Bilkent University Ankara Turkey Tokyo Medical & Dental University Hospital Tokyo Japan Department of Biomedicine Aarhus University Aarhus Denmark Department of Paediatric Infectious Diseases and Virology Imperial College London London UK Centre for Paediatrics and Child Health Faculty of Medicine Imperial College London London UK Hospital Universitari de Bellvitge L’Hospitalet de Llobregat Barcelona Spain Department of Medicine Center for Hematology and Regenerative Medicine Karolinska Institutet Stockholm Sweden Department of Paediatrics & Adolescent Medicine The University of Hong Kong Hong Kong China Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA
出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)
年 卷 期：2021年第43卷第11期
页 面：1947-1947页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：ANRS Nord-Sud, (21-COVR-0039, ANR-20-CE93-003, ANR-20-CO11-0001, ANRS-COV05) Emergent Ventures Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence, (ANR-10-LABX-62-IBEID) Square Foundation Yale High Performance Computing Center National Institutes of Health, NIH Howard Hughes Medical Institute, HHMI National Human Genome Research Institute, NHGRI, (U24HG008956, UM1HG006504) National Human Genome Research Institute, NHGRI NIH Office of the Director, OD, (S10OD018521) NIH Office of the Director, OD National Institute of Allergy and Infectious Diseases, NIAID, (R01AI088364, R01AI163029) National Institute of Allergy and Infectious Diseases, NIAID Fisher Center for Alzheimer's Research Foundation Glenn Foundation for Medical Research, GFMR St. Giles Foundation Meyer Foundation National Center for Advancing Translational Sciences, NCATS, (UL1 TR001866) National Center for Advancing Translational Sciences, NCATS JPB Foundation, JPBF Horizon 2020 Framework Programme, H2020, (824110) Horizon 2020 Framework Programme, H2020 Rockefeller University Fondation du Souffle, FdS Institut des maladies génétiques Imagine Center for Mendelian Genomics, University of Washington, UWCMG SCOR Corporate Foundation for Science Ministry of Higher Education, Research and Innovation, MoHERI, (MESRI-COVID-19) Ministry of Higher Education, Research and Innovation, MoHERI Agence Nationale de la Recherche, ANR, (ANR-10-IAHU-01) Agence Nationale de la Recherche, ANR Institut National de la Santé et de la Recherche Médicale, Inserm Fondation pour la Recherche Médicale, FRM, (ANR-20-COVI-0003, EQU201903007798) Fondation pour la Recherche Médicale, FRM Université Paris-Saclay, (EA20170638020) Université Paris-Saclay Fondation Bettencourt Schueller Regione Lazio, (A0375-2020-36663) Regione Lazio
摘 要：SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.
维普期刊数据库