Association between serum uric acid level and mortality in China

作     者：Dong-Yuan Chang Jin-Wei Wang Min Chen Lu-Xia Zhang Ming-Hui Zhao Chang Dong-Yuan;Wang Jin-Wei;Chen Min;Zhang Lu-Xia;Zhao Ming-Hui

作者机构：Renal DivisionDepartment of MedicinePeking University First HospitalInstitute of NephrologyPeking UniversityBeijing 100034China Key Laboratory of Renal DiseaseNational Health Commission of the People’s Republic of ChinaBeijing 100034China Key Laboratory of Chronic Kidney Disease Prevention and TreatmentPeking UniversityMinistry of EducationBeijing 100034China Research Units of Diagnosis and Treatment of Immune-mediated Kidney DiseasesChinese Academy of Medical SciencesBeijing 100034China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第17期

页      面：2073-2080页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Nos.91846101,81771938,81900665,82003529,82090021) Beijing Nova Programme Interdisciplinary Cooperation Project(No.Z191100001119008) National Key R&D Program of the Ministry of Science and Technology of China(No.2019YFC2005000) Chinese Scientific and Technical Innovation Project 2030(No.2018AAA0102100) the University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research(Nos.BMU2018JI012,BMU2019JI005) CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-046) PKU-Baidu Fund(No.2019BD017) 

主　　题：Cardiovascular diseases Sex characteristics Serum uric acid China Cohort study Mortality Population-based 

摘      要：Background:Whether there is an association between serum uric acid(SUA)level and risk of mortality in the general population remains *** on the China National Survey of Chronic Kidney Disease linked to mortality data,a population-based cohort study was performed to investigate the association between SUA level and all-cause mortality,cardiovascular disease(CVD)mortality,and cancer mortality in ***:The survival status of participants in the cross-sectional survey was identified from January 1,2006 to December 31,*** 33,268 individuals with complete SUA data among the 47,204 participants were included in the *** determined the rates of all-cause mortality,CVD mortality,and cancer *** used Cox proportional hazards regression models to evaluate the effect of the SUA level on ***:During a total of 297,538.4 person-years of follow-up,1282 deaths *** the Cox proportional hazards regression model,the rate of all-cause mortality,CVD mortality,and cancer mortality had a U-shaped association with SUA levels only in men,whereas no significant associations were detected in *** all-cause mortality in men,the multivariable-adjusted hazard ratios(HRs)in the first,second,and fourth quartiles compared with the third quartile were 1.31(95%confidence interval[CI]1.04–1.67),1.17(95%CI 0.92–1.47),and 1.55(95%CI 1.24–1.93),*** CVD mortality,the corresponding HRs were 1.47(95%CI 1.00–2.18),1.17(95%CI 0.79–1.75),and 1.67(95%CI 1.16–2.43),*** the cancer mortality rate,only a marginally significant association was detected in the fourth quartile compared with the third quartile with an HR of 1.43(95%CI 0.99–2.08).Conclusions:The association between SUA and mortality differed by *** demonstrated a U-shaped association with SUA levels for all-cause and CVD mortalities among men in China.