检索结果-南通市图书馆

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of histology and embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Application of task-driven teaching method in histology and embryology experiment teaching

在线全文

学校读者我要写书评

暂无评论

Application of task-driven teaching method in histology and ...

E2F transcription factors and digestive system malignancies:How much do we know?

中国解剖学会2019年年会

作者： Wa Yuan Tongqiang Chen Department of histology and embryology Gannan Medical University

＜正＞In order to promote students’understanding of the theoretical knowledge of histology and embryology,to enhance students’ability to observe and identify specimens,to enhance students’ability to solve problems with knowledge,and to improve the experimental teaching effect of histology and *** the experimental

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第29期20卷 10212-10216页

作者： Konstantinos Evangelou Sophia Havaki Athanassios Kotsinas laboratory histology-embryology Medical SchoolNational and Kapodistrian University of Athens

The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. Accumulating data suggest that there is no specific role for each individual E2F member. Instead, each E2F can exert a variety of cellular effects, some of which represent opposing ones. For instance, specific E2Fs can activate transcription and repression, promote or hamper cell proliferation, augment or inhibit apoptosis, all being dependent on the cellular context. This complexity reflects the importance that these transcription factors have on a cell’s fate. Thus, delineating the specific role for each E2F member in specific malignancies, although not easy, is a challenging and continuously pursued task, especially in view of potential E2F targeted therapies. Therefore, several reviews are continuously trying to evaluate available data on E2F status in various malignancies. Such reviews have attempted to reach a consensus, often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs. However they frequently miss spatial and temporal alterations of these factors during tumor development, which should also be considered in conjunction with the status of the regulatory networks that these factors participate in. In the current ‘‘Letter to the Editor’’, we comment on the flaws, misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies.

关键词： E2F Hepatocellular carcinoma Pancreatic ductal adenocarcinoma Gastrointestinal tract Digestive system p53 p73 Cancer Apoptosis Proliferation

Effect of Luteolin on Biochemical,Immunohistochemical,and Morphometrical Changes in Rat Spinal Cord following Exposure to a 900 MHz Electromagnetic Field

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第8期33卷 593-602页

作者： Ahmad Yahyazadeh Berrin Zuhal Altunkaynak Department of histology and embryology Faculty of MedicineKarabuk UniversityKarabukTurkey Department of histology and embryology Faculty of MedicineOkan UniversityIstanbulTurkey

Objective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field(EMF)on the cervical spinal cord(CSC)of rats and the possible protective effect of luteolin(LUT)against CSC tissue *** Quantitative data were obtained via stereological,biochemical,immunohistochemical,and histopathological *** investigated morphometric value,superoxide dismutase(SOD)level,and the expression of high-mobility group box 1 protein molecules,as well as histological *** The total number of motor neurons in the EMF group significantly decreased in comparison with that in the control group(P<0.05).In the EMF+LUT group,we found a significant increase in the total number of motor neurons compared with that in the EMF group(P<0.05).SOD enzyme activity in the EMF group significantly increased in comparison with that in the control group(P<0.05).By contrast,the EMF+LUT group exhibited a decrease in SOD level compared with the EMF group(P<0.05).Conclusion Our results suggested that exposure to EMF could be deleterious to CSC ***,the protective efficacy of LUT against SC damage might have resulted from the alleviation of oxidative stress caused by EMF.

关键词： Electromagnetic field Luteolin Motor neuron Oxidative stress Rat Spinal cord

Exploratory practice of bilingual education integrated with the PBL model in the teaching of histology and embryology

在线全文

学校读者我要写书评

暂无评论

Medical Bulletin of Shanghai Jiaotong University 2015年第2期27卷 165-168页

作者： Ting-ting WU Jian-guo LI Song YU Zhi-de DING Chen XU Department of Anatomy Histology and EmbryologyShanghai Jiao Tong University School of Medicine

The bilingual education integrated with PBL method is a new teaching model which gives consideration to knowledge,ability and professional foreign *** reflects the international integration for the reform idea of medical *** teaching practice indicated this model might be feasible in histology and *** brings not only the classic medical knowledge but also the latest medical developments to the *** new teaching model plays a role in the cultivation of the ability to solve problems independently and team spirit for *** helps students to improve their knowledge,skills,level of foreign language and quality.

关键词： reform of medical education bilingual education problem-based learning histology and embryology

Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas

在线全文

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第4期23卷 332-334页

作者：唐立华刘胜洪王芳刘子龙许耘王小丽李肇春 Department of histology and embryology Department of Reproductive Medicine

In situ hybridization and immunocytochemical techniques were employed to examine the expression of matrix metalloproteinases 1 (MMP 1) and to identify the pattern of its distribution in rat pancreas. The results indicated that the signal of MMP 1 mRNA and MMP 1 positive immunoreaction were detected in some fiberoblasts around interlobular ducts and exocrine cell in margin acinus of some lobules, but the signal of MMP 1 mRNA and MMP 1 positive immunoreaction could not be detected in most of other acinus and islets of pancreas. It is concluded that the expression of MMP 1 in above cells of rat might play an important role in acinar proliferation and differentiation of rat pancreatic tissues.

关键词： matrix metalloproteinases 1 in situ hybridization pancreas rat

MITOSIS OF NERVE CELLS IN THE CEREBRAL CORTEX OF ADULT RATS

在线全文

学校读者我要写书评

暂无评论

Science in China,Ser.B 1982年第3期25卷 286-291页

作者：徐静 Department of histology and embryology Chinese Capital Medical College

Adult rats 4--5 months old and 150--200g in body weight were used in this *** were made with antiseptic precaution by excising portions (0.7×0.4×0.1cm) of thecerebral cortices under ether anesthesia. The animals were sacrificed by decapitation at thetime intervals ranging from 1 to 30 days after the operation. Specimens of the brain wereremoved from the lesions with their adjacent normal areas, and processed for histological andhistochemical studies. Mitotic figures were observed in nerve cells adjacent to the lesions. The mitotic processof these neurons is similar to that of the other tissue cells, as it can also be divided into fourstages--prophase, metaphase, anaphase and telophase. However, neurons are entirely dif-ferent from the neuroglia and other tissue cells in that these have characteristic cell pro-cesses, i. e. axon and dendrites, while most of the neurons are pyramidal cells of layers Ⅱand Ⅴ of the cerebral cortex. The other characteristic feature is that the dividing neuroncontains Nissl bodies in the cytoplasm.

关键词： MITOSIS OF NERVE CELLS IN THE CEREBRAL CORTEX OF ADULT RATS