Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas

作     者：唐立华 刘胜洪 王芳 刘子龙 许耘 王小丽 李肇春 TANG Lihua 1,LIU Shenghong 1,WANG Fang , LIU Zilong 2, XU Yun , WANG Xiaoli , LI Zhaochun 1Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 2Department of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030

作者机构：Department of Histology and Embryology Department of Reproductive Medicine 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2003年第23卷第4期

页      面：332-334页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：matrix metalloproteinases 1 in situ hybridization pancreas rat 

摘      要：In situ hybridization and immunocytochemical techniques were employed to examine the expression of matrix metalloproteinases 1 (MMP 1) and to identify the pattern of its distribution in rat pancreas. The results indicated that the signal of MMP 1 mRNA and MMP 1 positive immunoreaction were detected in some fiberoblasts around interlobular ducts and exocrine cell in margin acinus of some lobules, but the signal of MMP 1 mRNA and MMP 1 positive immunoreaction could not be detected in most of other acinus and islets of pancreas. It is concluded that the expression of MMP 1 in above cells of rat might play an important role in acinar proliferation and differentiation of rat pancreatic tissues.