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Four Pins Assisted Reduction of Complex Segmental Femoral Fractures: a Technique for Closed Reduction

Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第6期34卷 912-916页

作者：郑占乐于贤许国强陈伟张英泽焦振清 Orthopedic Trauma Center and Key biomechanical laboratory of orthopedics The Third Hospital of Hebei Medical University Department of Endocrinology The General Hospital of Hebei Province Hebei Medical University

Complex segmental femoral fractures are usually not amenable to closed reduction. The purpose of this study was to evaluate a series of patients who had undergone four pins assisted reduc- tion and intramedullary nail fixation to determine the therapeutic effect of this closed reduction tech- nique. Between December 2010 and January 2013, 15 consecutive patients with segmental femoral fractures were treated with four pins assisted reduction at our hospital. The patient was placed in a supine position on a radiolucent fracture table and a. gentle traction was attempted on the limb. Usu- ally, the proximal fracture segment exhibited the typical deformity of flexion, external rotation, and abduction, the middle segment exhibited adduction and distal fracture segment exhibited flexion. Four Schanz pins were placed percutaneously to fix one cortex and did not penetrate into the me- dullary cavity, and the ＂T＂ sharp handles were fixed on the Schanz pins. The fragments were then re- duced by reversing the deforming forces for segmental fractures by two assistants~ And then, the re- duction could be easily achieved and intramedullary nail fixation was performed. Radiographs were evaluated for the quality of the reduction and fracture union. Closed reduction was achieved in all pa- tients using the four pins technology. All 15 fractures united uneventfully. No patient had a rotational malunion or limb length discrepancy at the time of the last follow-up. Thirteen of the fifteen （86.7%） patients had anatomic reduction and two of them （13.3%） had minor varus alignment of 3° and 5°. Knee stiffness was Observed in 2 patients and no implant failure was observed. Surgical treatment of complex segmental femoral fractures With four pins assisted reduction and intramedullary nail fixation techniques can result in excellent reductions and a high union rate.

关键词： fracture closed reduction segmental fracture femur

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Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum:report of six cases

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Regenerative Biomaterials 2022年第1期9卷 156-162页

作者： Yitian Wang Xiangfeng Li Yi Luo Li Zhang Hezhong Chen Li Min Qing Chang Yong Zhou Chongqi Tu Xiangdong Zhu Xingdong Zhang Department of orthopedics Orthopedics Research InstituteWest China HospitalSichuan UniversityChengdu 610041China Bone and Joint 3D-Printing&biomechanical laboratory Department of OrthopedicsWest China HospitalSichuan UniversityNo.37 GuoxuexiangChengdu 610041SichuanChina National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Sichuan Baiameng Bioactive Materials Limited Liability Company No.37 GuoxuexiangChengdu 610041SichuanChina

This study aimed at evaluating the possibility and effectiveness of osteoinductive bioceramics to fill the tumor cavity following the curettage of sacral giant cell tumor(GCT).Six patients(four females and two males,25–45 years old)underwent nervesparing surgery,in which the tumor was treated by denosumab,preoperative arterial embolization and extensive *** remaining cavity was filled with commercial osteoinductive calcium phosphate(CaP)bioceramics,whose excellent osteoinductivity was confirmed by intramuscular implantation in beagle *** patients were followed by computed tomography(CT)scans *** to the modified Neer criterion,five cases obtained Type I healing status,and one case had Type *** the latest follow-up,no graft-related complications and local recurrence were *** CT scan indicated a median time of healing initiation of 3months postoperatively,and the median time for relatively complete healing was *** excellent bone regenerative ability of the ceramics was also confirmed by increased CT attenuation value,blurred boundary and cortical rim *** conclusion,osteoinductive CaP bioceramics could be an ideal biomaterial to treat the large remaining cavity following extensive curettage of sacral ***,further investigation with more cases and longer follow-up was required to confirm the final clinical effect.

关键词： calcium phosphate bioceramics giant cell tumor sacrum osteoinductivity

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Classification and reduction manipulation of fractures in Chinese traditional Mongolian osteopathy

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Journal of Traditional Chinese Medicine 2014年第1期34卷 122-126页

作者： Mei Wang Zhanhong Bao Namula Zhao Department of orthopedics and Traumatology Inner Mongolia International Hospital of Mongolian Medicine Department of orthopedics andTraumatology Hospital of Inner Mongolian Osteopathy of Tongliao Municipality Department of orthopedics andTraumatology Inner Mongolia International Hospital of Mongolian Medicine Science Research Base of orthopedics and Traumatology Inner Mongolia Nation University

OBJECTIVE:To explore the concept of classification and reduction manipulation of fractures in Chinese traditional Mongolian ***:Based on the linear classification of fractures in Chinese traditional Mongolian osteopathy and the practice of reduction manipulation,a dynamic classification and reduction manipulation concept of fractures was established with the use of modern biomechanical principles and ***:We classified the linear classification and reduction manipulation of fractures in Chinese traditional Mongolian osteopathy based on the achievement of fracture line and used the cause of the formation of the fracture line for our dynamic classification and reduction manipulation of fractures ***:The etiology of the formation of fracture lines can be used to decrease diagnostic error,increase therapeutic effects of manipulation,and further provide a new concept and method for the development of the reduction concept of fractures.

关键词： Fractures bone Traditional Mongolian osteopathy Linear classification Dynamic classifica-tion Reduction manipulation

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biomechanical evaluation of anterior transpedicular screw-artificical vertedral body fixation in lower cervical spine

Biomechanical evaluation of anterior transpedicular screw-ar...

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第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议

作者： Jinyuan Zhang Weidong Wu Peidong Sun Zhenyu Bi Jun Ouyang Department of Anatomy Southern Medical UniversityGuandong Provincial Medical Biomechanical Key Laboratory Department of orthopedics Wuzhou Red Cross Hospital

Objective:To evaluate the biomechanical characteristics of anterior transpedicular screw-artificial vertebral body(AVB).AVB is a new fusion instrumentationation which was independent design based on the anterior transpedicular screw(ATPS).ATPS combines advantages of anterior approach and pedicle screw,which has outstanding pull-out resistance,large surgery field,little damage,and close to the *** biomechanics of

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Jumbo Bionic Trabecular Metal Acetabular Cups Improve Cup Stability During Acetabular Bone Defect Reconstruction:A Finite Element Analysis Study

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Journal of Bionic Engineering 2023年第6期20卷 2814-2825页

作者： Jianlin Xiao Haowen Xue Zhihui Qian Shenghao Xu Xianyue Shen Zhuo Zhang Lei Ren Luquan Ren Department of orthopedics China-Japan Union Hospital of Jilin UniversityChangchun130033China Key laboratory of Bionic Engineering Ministry of Education Changchun130025China Department of orthopedics The Second Hospital of Jilin UniversityChangchun130041China Department of orthopedics The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial HospitalHefei230001China Weihai Institute for Bionics-Jilin University Weihai264400China

The biomechanical effects of acetabular revision with jumbo cups are *** study aimed to compare the biomechanical effects of bionic trabecular metal *** jumbo cups for the revision of acetabular bone *** designed and reconstructed American Academy of Orthopaedic Surgeons(AAOS)type I–III acetabular bone defect models using computed tomography scans of a man without acetabular bone *** implantation of titanium and trabecular metal jumbo cups was *** distribution and relative micromotion between the cup and host bone were assessed using finite element *** stress on the screws fixing the cups was also *** contact stress analysis showed that the peak contact stress between the titanium jumbo cup and the host bone was 21.7,20.1,and 23.8 MPa in the AAOS I–III models,respectively;the corresponding values for bionic tantalum jumbo cups decreased to 4.7,6.7,and 11.1 *** of the relative micromotion showed that the peak relative micromotion between the host bone and the titanium metal cup was 10.2,9.1,and 11.5μm in the AAOS I–III models,respectively;the corresponding values for bionic trabecular metal cups were 17.2,18.2,and 31.3μ*** peak contact stress on the screws was similar for the 2 cup types,and was concentrated on the screw ***,acetabular reconstruction with jumbo cups is biomechanically *** recommend trabecular metal cups due to their superior stress distribution and higher relative micromotion,which is within the threshold for adequate bone ingrowth.

关键词： Acetabular bone defect Finite element analysis Trabecular metal Jumbo cup

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Biological conduits combining bone marrow mesenchymal stem cells and extracellular matrix to treat long-segment sciatic nerve defects

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Neural Regeneration Research 2015年第6期10卷 965-971页

作者： Yang Wang Zheng-wei Li Min Luo Ya-jun Li Ke-qiang Zhang Department of orthopedics China-Japan Friendship HospitalJilin University Department of orthopedics Second HospitalJilin University Mathematics School Jilin University

The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors related to the sciatic nerve are available. In the present study, rabbit models of 10-mm sciatic nerve defects were prepared. The rabbit models were repaired with autologous nerve, a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells, or a polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel. After 24 weeks, mechanical testing was performed to determine the stress relaxation and creep parameters. Following sciatic nerve injury, the magnitudes of the stress decrease and strain increase at 7,200 seconds were largest in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group, followed by the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group, and then the autologous nerve group. Hematoxylin-eosin staining demonstrated that compared with the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells group and the autologous nerve group, a more complete sciatic nerve regeneration was found, including good myelination, regularly arranged nerve fibers, and a completely degraded and resorbed conduit, in the polylactic glycolic acid conduit ＋ bone marrow mesenchymal stem cells ＋ extracellular matrix gel group. These results indicate that bridging 10-mm conduit ＋ bone marrow mesenchymal stem sciatic nerve defects with a polylactic glycolic acid cells ＋ extracellular matrix gel construct increases the stress relaxation under a constant strain, reducing anastomotic tension. Large elongations under a constant physiological load can limit the anastomotic opening and shift, which is beneficial for the regeneration and functional reconstruction of sciatic nerve. Better regeneration was fou

关键词： nerve regeneration peripheral nerve injury rabbits sciatic nerve injury autologous nerye repair polylactic glycolic acid conduit extracellular matrix gel grafting stress relaxation creep viscoelasticity histomorphology electrophysiology neural regeneration

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biomechanical properties of acellular sciatic nerves treated with a modified chemical method

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Neural Regeneration Research 2011年第4期6卷 252-256页

作者： Xinlong Ma Zhao Yang Xiaolei Sun Jianxiong Ma Xiulan Li Zhenzhen Yuan Yang Zhang Honggang Guo Department of orthopedics Tianjin Hospital Tianjin 300211 China Department of orthopedics General Hospital of Tianjin Medical University Tianjin 300052 China

Nerve grafts are able to adapt to surrounding biomechanical environments if the nerve graft itself exhibits appropriate biomechanical properties （load, elastic modulus, etc.）. The present study was designed to determine the differences in biomechanical properties between fresh and chemically acellularized sciatic nerve grafts. Two different chemical methods were used to establish acellular nerve grafts. The nerve was chemically extracted in the Sondell method with a combination of Triton X-100 （nonionic detergent） and sodium deoxycholate （anionic detergent）, and in the modified method with a combination of Triton X-200 （anionic detergent）, sulfobetaine-10 （SB-10, amphoteric detergents）, and sulfobetaine-16 （SB-16, amphoteric detergents）. Following acellularization, hematoxylin-eosin staining and scanning electron microscopy demonstrated that the effect of acellularization via the modified method was similar to the traditional Sondell method. However, effects of demyelination and nerve fiber tube integrity were superior to the traditional Sondell method. biomechanical testing showed that peripheral nerve graft treated using the chemical method resulted in decreased biomechanical properties （ultimate load, ultimate stress, ultimate strain, and mechanical work to fracture） compared with fresh nerves, but the differences had no statistical significance （P 〉 0.05）. These results demonstrated no significant effect on biomechanical properties of nerves treated using the chemical method. In conclusion, nerve grafts treated via the modified method removed Schwann cells, preserved neural structures, and ensured biomechanical properties of the nerve graft, which could be more appropriate for implantation studies.

关键词： biomechanics acellular nerve sciatic nerve Schwann cells nerve implantation neural regeneration

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Anterior Lumbar Intervertebral Fusion with Artificial Bone in Place of Autologous Bone

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第3期23卷 300-301页

作者：徐卫国陈安民冯旭印卫锋 Department of orthopedics

The feasibility of anterior lumbar intervertebral fusion with artificial bone in place of autogenous bone was investigated Porous hydroxyapatite(HA)/ZrO 2 ceramics loading bone morphogenetic protein (BMP) were implanted after removal of lumbar vertebral disc in rabbits The adjacent intervertebral discs were also removed by the same way and autogenous illic bone was implanted SEM observation and biomechanical test were carried out Compound bone had a bit lower osteoinductive activity than autogenous bone by SEM(Osteoindutive activity of artificial bone in 12 weeks was the same as that of autogenous bone in 9 weeks) biomechanical test revealed that compound bone had lower anti-pull strength than autogenous bone ( P0 05) It was concluded that compound bone could be applied for anterior spinal fusion, especially for those patients who can't use autogenous bone

关键词： bioceramics bone morphogenetic protein spinal fusion bone implant

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Connexin 43 hemichannels protect bone loss during estrogen deficiency

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Bone Research 2019年第2期7卷 183-194页

作者： Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang Department of Orthopaedics Jinan Central Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Biochemistry and Structural Biology UT Health San AntonioSan AntonioTX 78229USA Department of orthopedics UT Health San AntonioSan AntonioTX 78229USA Department of biomechanical Engineering University of Texas at San AntonioSan AntonioTX 78249USA

Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone *** 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and *** showed here that estrogen deficiency reduced Cx43 expression and HC *** determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were *** results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty ***,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 *** data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency.

关键词： hemichannels protect estrogen deficiency

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Immediate versus delayed primary nerve repair in the rabbit sciatic nerve

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Neural Regeneration Research 2013年第36期8卷 3410-3415页

作者： Ahmet Piskin Berrin Zühal Altunkaynak Atilla tlak Hicabi Sezgin Ozgür Yazici Süleyman Kaplan Department of orthopedics and Traumatology School of Medicine Ondokuz Mayis University Department of Histology and Embryology School of Medicine Ondokuz Mayis University Department of orthopedics and Traumatology School of Medicine Giresun University

It is well known that peripheral nerve injury should be treated immediately in the clinic, but in some instances, repair can be delayed. This study investigated the effects of immediate versus delayed （3 days after injury） neurorrhaphy on repair of transected sciatic nerve in New Zealand rabbits using stereological, histomorphological and biomechanical methods. At 8 weeks after immediate and delayed neurorrhaphy, axon number and area in the sciatic nerve, myelin sheath and epineurium thickness, Schwann cell morphology, and the mechanical property of nerve fibers did not differ obviously. These results indicate that delayed neurorrhaphy do not produce any deleterious effect on sciatic nerve repair.

关键词： neural regeneration delayed peripheral nerve repair sciatic nerve peripheral nerve injurystereology microscopy biomechanics neuroregeneration

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