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One-pot synthesis of MoSe2 hetero-dimensional hybrid self-assembled by nanodots and nanosheets for electrocatalytic hydrogen evolution and photothermal therapy

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Nano Research 2017年第8期10卷 2667-2682页

作者： Baoguang Mao Tao Bao Jie Yu Lirong Zheng Jinwen Qin Wenyan Yin Minhua Cao Key laboratory of Cluster Science Ministry of Education of China School of Chemistry and Chemical Engineering Beijing Institute ot Technology Beijing 100081 China Beijing Key laboratory of Photoelectronic/Electrophotonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety institute of High Energy Physics Chinese Academy of Sciences Beijing 700049 China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

We designed and prepared a hetero-dimensional hybrid （HDH） based on molybdenum selenide （MoSe2） nanodots （NDs） anchored in few-layer MoSe2 nanosheets （NSs）（MoSe2 HDH） via a one-pot hydrothermal process. The MoSe2 HDH exhibits excellent electrocatalytic activity toward hydrogen evolution reaction （HER）. This is because, on the one hand, the edge-abundant features of MoSe2 NDs and the unique defect-rich structure at the interface of MoSe2 NSs/NDs could bring in more active sites for HER; on the other hand, the random stacking of the flake-like MoSe2 NSs on the surface of the supporting electrode may achieve efficient charge transport. Additionally, the MoSe2 HDH shows good water stability, desirable biocompatibility, and high near infrared （NIR） photothermal conversion efficiency. Therefore, the MoSe2 HDH is investigated as a nanomedicine in NIR photothermal therapy （PTT） for cancer. Specifically, the MoSe2 HDH can be applied as a dual-modal probe for computed tomography （CT） and photoacoustic tomography （PA） imaging owing to its strong X-ray attenuation ability and NIR absorption. Therefore, the MoSe2 HDH, combining PTT with CT/PA imaging into one system, holds great potential for imaging-guided cancer theranostics. This work may provide an ingenious strategy to prepare other hetero-dimensional layered transition metal dichalcogenides.

关键词： layered transition merat dichalcogenides molybdenum selenide hetero-dimensional hybrid hydrogen evolution reaction photothermal therapy

Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy

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Nano Research 2023年第12期16卷 13134-13163页

作者： Fuming Liang Qing You Xiaopeng Ma Huayi Wang Chen Wang Zhaohui He Yanlian Yang Ling Zhu CAS Key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China National Center for Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China The First Affiliated Hospital University of Science and Technology of China Anhui Provincial HospitalHefei 230000China

Precise imaging is essential for the accurate diagnosis and surgical guidance of brain diseases but it is challenging due to the difficulties in crossing the blood-brain barrier(BBB),the difficulties in disease lesion targeting,and the limited contrast in the brain ***-imaging agents were characterized by functionalized modifications,high contrast,small size,and high biocompatibility,thus providing advantages in BBB crossing,brain targeting,imaging resolution,and real-time monitoring,holding great potential in brain disease *** characteristics in brain environment and brain diseases(e.g.,marker proteins on the BBB,the pathogenic proteins in the neurodegenerative diseases or brain tumors,and the tumor and inflammatory microenvironment)provide opportunities for the functionalized nano-imaging agents to improve BBB crossing and disease ***,the versatile nano-imaging agents are endowed with therapeutic agents to facilitate the theranostics of brain ***,we summarized the common materials and imaging techniques of nano-imaging agents and their imaging treatment *** discussed their BBB penetration,environmental response for disease targeting,and therapeutic *** also provided insights on the advantages,challenges,and application of nano-imaging agents in detecting and treating brain diseases such as neurodegenerative diseases,brain tumors,stroke,and traumatic brain *** discussions will help develop nano-imaging agents-based theranostic platforms for the precise diagnosis and treatment of brain diseases.

关键词： brain disease nano-imaging agent blood-brain barrier environmentally responsive imaging treatment

Construction of AIEgen functionalized nanomicelles and their stability study through‘seesaw-like'fluorescence changes

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Chinese Chemical Letters 2023年第6期34卷 382-386页

作者： Xiaotong Wang Shizhu Chen Yaru Jia Kaihan Zhang Lili Ma Luwei Li Xingjie Liang Jinchao Zhang College of Chemistry and Environmental Science Chemical Biology Key Laboratory of Hebei ProvinceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071002China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Department of Chemistry The University of ManchesterManchester M139PLUnited Kingdom

As nanocarriers,nanomicelles play vital roles in the toolbox of drug *** stability of nanomicelles affects the nanomedicines'***,it is important to understand the stability of nanomicelles for further ***,we report a strategy to construct new nanomicelles(NM)by introducing aggregation-induced emission(AIE)functional group tetraphenylethylene(TPE)in the component polymer vitamin E(D-α-tocopheryl polyethylene glycol 1000 succinate)(TPGS).The stability of doxorubicin(DOX)loaded nanomicelles DOX@NM in different conditions was studied by fluorescence *** fluorescence changes of DOX@NM are‘seesaw-like'when they transform between assembled and disassembled *** the assembled form,TPE gives emission from AIE effect,while in the disassembled form,the fluorescence of DOX is observed due to the disappearance of ACQ effect.

关键词： Polymer nanomicelles Aggregation-induced emission Fluorescence ratio Stability Drug delivery system

Engineering Nano−Bio Interfaces from nanomaterials to Nanomedicines

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Accounts of Materials Research 2022年第8期3卷 812-829页

作者： Hao Zhao Yuqiao Wang Lin Bao Chunying Chen CAS Key laboratory for biomedical effects of nanomaterials and nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China

CONSPECTUS:The nano−bio interface refers to the physical interface between the biological system and nanoscale surface topography,functioning as the barrier between two phases where critical reactions *** the last two decades,advances in nanofabrication techniques have heralded a new research area utilizing precisely engineered surfaces and structures to control cell cycles,pathways of metabolism,immune responses,and so *** the cellular level,engineered nanomaterials(ENMs)with typical surfaces and structures have been shown to actively affect biological responses,such as stimulating macrophage polarization,monitoring reduction−oxidation equilibrium,and manipulating protease activities via tunable nano−bio *** this Account,we outline our recent progress in surface engineering and structural engineering to improve nano−bio interactions and the performance of *** regulate nanomaterial−molecule and nanomaterial−membrane interactions,we summarize the classical types of nano−bio interaction,extract the essential parameters in nanomaterial surface engineering and structural engineering,and propose effective techniques of surface engineering and structural *** start with identifying the types of dominant interactions between nanomedicines and vital biomolecules:nanonucleic acids,nanoproteins,and *** surface engineering strategies of nano−bio interface tailoring are then arranged into four perspectives:the protein corona(the two modes of protein corona formation and their impacts on altering the affinity profiles of nanomaterials to biological systems),thermoresponsive polymers in superficial modification(passive activation by in situ gelation and active regulation by photothermal conversion),stimulus-induced bonding groups(mediation of nanoparticle aggregation to balance the penetration depth and long-term retention),and inherent surface properties(surface roughness for maximized nano−bio adhesion,surface charge for

关键词： interface bonding roughness

The accurate localization of fluorescent nanoparticle Au-Ft in nu/nu mice kidney

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Journal of Innovative Optical Health Sciences 2014年第3期7卷 83-90页

作者： Hui Yang Cuji Sun Jun Jia Guangjun Nie Zhenyu Wu Department of Immunology Guang'anmen HospitalP.R.China Academy of Chinese Medical Sciences Beijing 100053P.R.China CAS Key laboratory for biomedical effects of nanomaterials&nanosafety Nationai Center for Nanoscience and Technology Beijing 100190 P.R.China Chilong Healthcare Intermational Limited Beijing 1000%0 P.R.China

Au-Ft,as a green synthesized nanoparticle,is composed of a ferritin nanocage enclosing a pair of Au nanoclusters *** previous study has demonstrated that Au-Ft can be an excellentfluorescent probe for whole body imaging of mice with kidney specific ***,the accuratelocalization of Au-Ft in kidney is still *** the current study,we detected and assessed the cellular and subcellular localization of Au-Ft in renal cortex and medulla of nu/nu mice after tailvein injection by using Nuance optical system(CRi,Woburn,USA)and inForm intelligent image analysis soft ware based on single cell *** obtained the fluorescence intensity and cellular location of kidney-targeting Au-Ft probe in particular cell of renal glomerulus or renaltubules,which provided valuable proofs to clarify the mechanism of Au-Ft selective enrichment in kidney and the associated metabolic processes.

关键词： Au-Ft nanoparticle kidney targeting cellular localization renal cortex and medlla multispectral imaging

Biodegradable cationic e-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent

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Science Bulletin 2015年第14期60卷 216-226,I0002页

作者：赵瑞芳王海季天骄 Greg Anderson 聂广军赵宇亮 Chinese Academy of Sciences Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology Department of Chemistry Tsinghua University Queensland Institute of Medical Research Royal Brisbane Hospital Herston QLD 4029 Australia

Biocompatible and biodegradable ε-poly-L- lysine （EPL）/poly （ε-caprolactone）（PCL） copolymer was designed and synthesized. The amphiphilic EPL-PCL copolymer could easily self-assembled into monodispersed nanoparticles （NPs）, which showed a broad-spectrum antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Interestingly, the antibacterial efficacy of the novel NPs is more potent than the cationic peptide EPL. To explore the underlying mechanism of the biodegradable cationic NPs, various possible antibacterial pathways have been validated. The NPs have been found that they can disrupt bacterial walls/ membranes and induce the increasing in reactive oxygen species and alkaline phosphatase levels. More importantly, the self-assembled NPs induced the changes in bacterial osmotic pressure, resulting in cell invagination to form holes and cause the leakage of cytoplasm. Taken together, our results suggest that the EPL-PCL NPs can be further developed to be a promising antimicrobial agent to treat infectious diseases as surfactants and emulsifiers to enhance drug encapsulation efficiency and antimicrobial activity.

关键词： EPL-PCL copolymers Biodegradable cationic nanoparticles Broad-spectrum antibacterial activity Disruption of bacterial walls/membranes Cell invagination

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Nanobiotechnology and nanomedicine:small change brings big difference

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Science China(Life Sciences) 2018年第4期61卷 371-372页

作者： Shizhu Chen Xing-Jie Liang CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China College of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University Baoding 071000 China University of Chinese Academy of Sciences Beijing 100049 China

The physicist Richard Feynman put forward the concept of nanotechnology in his famous speech, ＂There＇s Plenty of Room at the Bottom,＂ at the annual meeting of the American Physical Society on December 29, 1959. He began with a ＂bottom up＂ approach and proposed assembling from a single molecule or even an atom to meet the requirements of the design. He indicated that the laws of physics do not rule out the possibility of making an object by atom stack and predicted that our precise control over tiny objects could significantly expand the scope of material attributes acquired by human beings. Furthermore, in his report published in 1960, Richard Feynman proposed the concept of nanosur- gery and nanodrug delivery devices for the first time and further predicted that nanotechnology will play an important role in the field of life and health sciences in the future （Feynman, 1960）.

关键词：硬币物理学家纳米技术原子集合单个分子精确控制底部预言

Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2059-2069页

作者： Bozhao Li Jingyan Wei Chunzhi Di Zefang Lu Feilong Qi Yinlong Zhang Wei Sun Leong Lele Li Guangjun Nie Suping Li College of Pharmaceutical Science Jilin UniversityChangchun 130021China CAS Key laboratory for biomedical effects of nanomaterials&nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Materials Science and Engineering National University of Singapore117575Singapore

Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer *** vascular coagulation agents,the extracellular domain of coagulation-inducing protein tissue factor,truncated tissue factor(tTF),is the most widely *** the truncated protein exhibits no coagulation activity and is rapidly cleared in the circulation,free tTF cannot be used for cancer treatment on its own but must be combined with other *** here developed a novel,tumor-specific tTF delivery system through coupling tTF with the DNA aptamer,AS1411,which selectively binds to nucleolin receptors overexpressing on the surface of tumor vascular endothelial cells and is specifically cytotoxic to target *** administration of the tTF-AS1411 conjugates into tumor-bearing animals induced intravascular thrombosis solely in tumors,thus reducing tumor blood supply and inducing tumor necrosis without apparent side *** conjugate represents a uniquely attractive candidate for the clinical translation of vessel occlusion agent for cancer therapy.

关键词： Tumor targeted delivery Truncated tissue factor(tTF) AS1411 aptamer Thrombosis Tumor infarction

Phage capsid nanoparticles as multivalent inhibitors of viral infections

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Science Bulletin 2020年第24期65卷 2050-2052,M0004页

作者： Manzar Abbas Muhammad Ovais Chunying Chen Institute for Molecules and Materials Radboud UniversityNijmegen 6525 AJthe Netherlands CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for Nanotechnology Guangzhou 510700China

In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19 [2]. Coronavirus has a spike protein, which tends to bind with receptors present in the lung tissues, and that helps in its entry to the cells and replication inside [3]. Therefore, we are in need to design the multivalent nanomaterials, which can act as receptors to bind with spike protein of virus and stop its replication(Fig. 1).

关键词：病毒感染衣壳 lung