Construction of AIEgen functionalized nanomicelles and their stability study through‘seesaw-like'fluorescence changes

作     者：Xiaotong Wang Shizhu Chen Yaru Jia Kaihan Zhang Lili Ma Luwei Li Xingjie Liang Jinchao Zhang Xiaotong Wang;Shizhu Chen;Yaru Jia;Kaihan Zhang;Lili Ma;Luwei Li;Xingjie Liang;Jinchao Zhang

作者机构：College of Chemistry and Environmental ScienceChemical Biology Key Laboratory of Hebei ProvinceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationHebei UniversityBaoding 071002China CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Department of ChemistryThe University of ManchesterManchester M139PLUnited Kingdom 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第6期

页      面：382-386页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.31971304,22007027) Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(No.B2021201038) One Hundred Talent Project of Hebei Province(No.E2020050010) Post-graduate’s Innovation Fund Project of Hebei University(No.HBU2022bs011) 

主　　题：Polymer nanomicelles Aggregation-induced emission Fluorescence ratio Stability Drug delivery system 

摘      要：As nanocarriers,nanomicelles play vital roles in the toolbox of drug *** stability of nanomicelles affects the nanomedicines ***,it is important to understand the stability of nanomicelles for further ***,we report a strategy to construct new nanomicelles(NM)by introducing aggregation-induced emission(AIE)functional group tetraphenylethylene(TPE)in the component polymer vitamin E(D-α-tocopheryl polyethylene glycol 1000 succinate)(TPGS).The stability of doxorubicin(DOX)loaded nanomicelles DOX@NM in different conditions was studied by fluorescence *** fluorescence changes of DOX@NM are‘seesaw-like when they transform between assembled and disassembled *** the assembled form,TPE gives emission from AIE effect,while in the disassembled form,the fluorescence of DOX is observed due to the disappearance of ACQ effect.