Phage capsid nanoparticles as multivalent inhibitors of viral infections

作     者：Manzar Abbas Muhammad Ovais Chunying Chen Manzar Abbas;Muhammad Ovais;陈春英

作者机构：Institute for Molecules and MaterialsRadboud UniversityNijmegen 6525 AJthe Netherlands CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China GBA Research Innovation Institute for NanotechnologyGuangzhou 510700China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2020年第65卷第24期

页      面：2050-2052,M0004页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100602[医学-中西医结合临床] 0702[理学-物理学] 10[医学] 

基　　金：financial support from the European Union’s Horizon 2020 program under grant 839177 (PEPREP) financial support from the Ministry of Science and Technology of China (2016YFA0201600, 2016YFE0133100) the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505) 

主　　题：病毒感染 衣壳 lung 

摘      要：In the present time, coronavirus disease COVID-19 has become prevalent across the globe and declared as a pandemic by the world health organization(WHO) [1]. As of now, many vaccines and medicines are in the approval process or at different stages of preclinical investigations to coup with the COVID-19 [2]. Coronavirus has a spike protein, which tends to bind with receptors present in the lung tissues, and that helps in its entry to the cells and replication inside [3]. Therefore, we are in need to design the multivalent nanomaterials, which can act as receptors to bind with spike protein of virus and stop its replication(Fig. 1).