Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy
作者机构：CAS Key Laboratory of Standardization and Measurement for NanotechnologyCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Department of NeurosurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China National Center for Nanoscience and TechnologyUniversity of Chinese Academy of SciencesBeijing 100049China The First Affiliated Hospital University of Science and Technology of ChinaAnhui Provincial HospitalHefei 230000China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第12期
页 面：13134-13163页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100204[医学-神经病学] 0836[工学-生物工程] 10[医学]
基 金：the National Key Research and Development Program of China(No.2021YFA1201504) the Strategic Priority Research Program of the Chinese Academy of Science(No.XDB36000000) the National Natural Science Foundation of China(Nos.31971295,21721002,and 81870927)
主 题：brain disease nano-imaging agent blood-brain barrier environmentally responsive imaging treatment
摘 要：Precise imaging is essential for the accurate diagnosis and surgical guidance of brain diseases but it is challenging due to the difficulties in crossing the blood-brain barrier(BBB),the difficulties in disease lesion targeting,and the limited contrast in the brain ***-imaging agents were characterized by functionalized modifications,high contrast,small size,and high biocompatibility,thus providing advantages in BBB crossing,brain targeting,imaging resolution,and real-time monitoring,holding great potential in brain disease *** characteristics in brain environment and brain diseases(e.g.,marker proteins on the BBB,the pathogenic proteins in the neurodegenerative diseases or brain tumors,and the tumor and inflammatory microenvironment)provide opportunities for the functionalized nano-imaging agents to improve BBB crossing and disease ***,the versatile nano-imaging agents are endowed with therapeutic agents to facilitate the theranostics of brain ***,we summarized the common materials and imaging techniques of nano-imaging agents and their imaging treatment *** discussed their BBB penetration,environmental response for disease targeting,and therapeutic *** also provided insights on the advantages,challenges,and application of nano-imaging agents in detecting and treating brain diseases such as neurodegenerative diseases,brain tumors,stroke,and traumatic brain *** discussions will help develop nano-imaging agents-based theranostic platforms for the precise diagnosis and treatment of brain diseases.
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