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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Fatty acids derived from oviposition systems guide female black soldier flies(Hermetia illucens)toward egg deposition sites

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Insect Science 2024年第4期31卷 1231-1248页

作者： Patrick Klüber Emna Arous Jeanny Jerschow Marco Fraatz Daniel Bakonyi Martin Rühl Holger Zorn Department Bioresources Fraunhofer Institute for Molecular Biology and Applied EcologyGiessenGermany Institute of Food Chemistry and Food Biotechnology Justus Liebig University GiessenGiessenGermany

The black soldier fly,Hermetia illucens,comes with big promises for industrial purposes since its larvae feed polyphagously on a broad spectrum of organic ***,research focusing on adult flies is scarce,which is inconsistent with their reproductive relevance within the rearing *** particular,directed oviposition is a challenge in artificial ***,decomposing organic matter is commonly used as oviposition substrate,which has extensive potential for improvement in view of the lack of standardization and the risk of microbial ***,we identified three fatty acids and one fatty acid methyl ester derived from the surface of old oviposition sites and targeted to elucidate their effect on preference behavior and oviposition site selection using Y-olfactometry and prepared oviposition sites,*** to tetradecanoic acid attracted gravid females and stimulated oviposition most strongly,while decanoic acid demonstrated a repulsive *** kept in mixed-sex populations were attracted by tetradecanoic acid,resulting in a higher egg mass found in the compound box(3.0–11.4 fold),a≥2.3 fold reduction of nonspecifically deposited eggs,and the highest total egg ***,decanoic and dodecanoic acid caused females to lay a greater proportion of eggs nonspecifically outside both *** data suggest that fatty acids,especially tetradecanoic acid,are important cues for oviposition site selection in black soldier *** order to achieve a directed oviposition behavior,the role of further short-and long-chain fatty acids as attractants should be examined.

关键词： black soldier fly Hermetia illucens fatty acids insects as food and feed oviposition oviposition site selection tetradecanoic acid

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Enemies atpeace:Recentprogressin Agrobacterium-mediated cereal transformation

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The Crop Journal 2024年第2期12卷 321-329页

作者： Shaoshuai Liu Ke Wang Shuaifeng Geng Moammar Hossain Xingguo Ye Aili Li Long Mao Karl-Heinz Kogel State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Phytopathology Centre for BioSystemsLand Use and NutritionJustus Liebig UniversityHeinrich Buff-Ring 26-32D-35392GiessenGermany

Agrobacterium tumefaciens mediated plant transformation is a versatile tool for plant genetic engineering following its discovery nearly half a century *** modifications were made in its application to increase efficiency,especially in the recalcitrant major cereals *** breakthroughs in transformation efficiency continue its role as a mainstream technique in CRISPR/Cas-based genome editing and gene *** modifications led to higher transformation frequency and lower but more stable transgene copies with the capability to revolutionize modern *** this review,we provide a brief overview of the history of Agrobacterium-mediated plant transformation and focus on the most recent progress to improve the system in both the Agrobacterium and the host recipient.A promising future for transformation in biotechnology and agriculture is predicted.

关键词： Agrobacterium tumefaciens Cereal species Genome editing Genetic engineering Plant breeding

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

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Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

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On-Surface Synthesis of Electron-Deficient Bisanthene Tetraimide

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CCS Chemistry 2024年第3期6卷 672-681页

作者： Ye Liu Liangliang Chen Hailong Li Xi-Sha Zhang Qigang Zhong Zhengming Hao Minghui Wu Yan-Ying Huang Lina Wang Minchong Sheng Miao Xie Haiming Zhang Deqing Zhang Lifeng Chi Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsu 215123 CAS Key Laboratory for Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 Institute of Applied Physics Justus Liebig University GiessenGiessen 35392

Imide-based conjugated molecules have emerged as a highly promising class of building blocks for constructing n-type semiconducting materials with lowlying lowest unoccupied molecular orbitals and exceptional *** imides,such as naphthalene diimides,perylene diimides and their lateral fused analogs,have been synthesized extensively,the design and synthesis of largerπ-extended molecules incorporating more than two imide groups are desirable but still very ***,we report the synthesis of an unprecedented electron-deficient bisanthene tetraimide(ATI)containing a bisantheneconjugated core and four five-membered imide groups,which was successfully achieved via a combined approach of solution and on-surface *** chemical structures,electronic states,formation mechanism and aromaticity of ATI were systematically investigated by scanning tunneling microscopy,noncontact atomic force microscopy,scanning tunneling spectroscopy,and density functional theory calculations.

关键词： on-surface synthesis electron-deficient bisanthene tetraimide dehydrocyclization low lowest unoccupied molecular orbital level

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The dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells

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Neuroprotection 2024年第1期2卷 4-15页

作者： Matteo Haupt Stefan T.Gerner Thorsten R.Doeppner Department of Neurology University of Gottingen Medical SchoolGottingenGermany Department of Neurology University Hospital GiessenGiessenGermany Center for Mind Brain and Behavior(CMBB)University of Marburg and Justus Liebig University GiessenMarburgGermany Department of Anatomy and Cell Biology Medical University of VarnaVarnaBulgaria Medipol university Istanbul Research InstituteforHealthSciencesand Technologies(SABITA)IstanbulTurkey

Stem cell-based therapies and extracellular vesicle(EV)treatment have demonstrated significant potential for neuroprotection against ischemic *** the neuroprotective mechanisms are not yet fully under-stood,targeting microglia is central to promoting *** are the resident immune cells of the central nervous *** cells are crucial in the pathogenesis of ischemic *** respond rapidly to the site of injury by releasing pro-inflammatory cytokines,phagocytizing dead cells and debris,and recruiting peripheral immune cells to the ischemic *** these responses are essential for clearing damage and initiating tissue repair,excessive or prolonged microglial activation can exacerbate brain injury,leading to secondary neuroinflammation and ***,microglia exhibit a dynamic range of activation states with the so-called M1 pro-inflammatory and M2 anti-inflammatory phenotypes,representing the two ends of the *** delivery of both EVs and stem cells modulates microglial activation,suppressing pro-inflammatory genes,influencing the expression of transcription factors,and altering receptor expression,ultimately contributing to *** findings underscore the importance of understanding the complex and dynamic role of microglia in the development of effective neuroprotective strategies to reduce the effects of ischemic *** this review,we examine the current state of knowledge regarding the role of microglia in ischemic stroke,including their molecular and cellular mechanisms,activation states,and interactions with other *** also discuss the multifaceted contributions of microglia to stem cell-and EV-based neuroprotection during an ischemic stroke to provide a comprehensive understanding of microglial functions and their potential implications in stroke therapies.

关键词： extracellular vesicle microglia neuroprotection stroke stem cells

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Solid-state batteries:from 'all-solid' to 'almost-solid'

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National Science Review 2023年第6期10卷 57-59页

作者： Hanyu Huo Jürgen Janek Institute of Physical Chemistry Justus Liebig University Giessen Center for Materials Research (ZfM) Justus Liebig University Giessen

Lithium-ion batteries (LIBs) have been the undisputed leading technology in electrochemical energy storage since they were commercialized in *** then,the mass manufacturing of LIBs has reached maturity,and we have also seen the realization of high energy density,long cycling stability and low *** technology enabled the huge success of mobile consumer electronics,with its usage in electric vehicles and other advanced *** to the use of organic solvents for the ele ctrolytes,LIBs are sensitive to high temperatures,lose performance at low temperatures and show inherent safety risks with increasing energy density (Fig.1a).As the performance of current LIBs is also limited,next-generation battery technologies are being intensively investigated,especially given the ever-increasing demand for high energy density as well as high power density.

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CRISPR-based genetic control strategies for insect pests

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Journal of Integrative Agriculture 2023年第3期22卷 651-668页

作者： Ying YAN Roswitha A.AUMANN Irina HÄCKER Marc F.SCHETELIG Department of Insect Biotechnology in Plant Protection Institute for Insect BiotechnologyJustus-Liebig-University GiessenGiessen 35394Germany

Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR(clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in more and more species, greatly facilitates the development of novel genetic control insect strains that can be used in area-wide and species-specific pest control programs. Here, we review the research progress towards state-of-art CRISPR-based genetic control strategies, including gene drive, sex ratio distortion, CRISPRengineered genetic sexing strains, and precision-guided sterile insect technique. These strategies’ working mechanisms,potential resistance development mechanisms, and regulations are illustrated and discussed. In addition, recent developments such as stacked and conditional systems are introduced. We envision that the advances in genetic technology will continue to be one of the driving forces for developing the next generation of pest control strategies.

关键词： insect pest genetic control sterile insect technique gene drive genetic sexing strains CRISPR-Cas9

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Supporting tumor therapy by exercise:boosting T cell immunity by myokines

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3177-3178页

作者： Kristina Gebhardt Karsten Kruger Department of Exercise Physiology and Sports Therapy Justus-Liebig-University of GiessenGiessenGermany

In a recent study published in Cancer Cell,Kurz et *** how exercise induces inhibitory effects on tumor growth by immuno-logical processes.1The investigation of these mechanisms is particularly signifcant because life... 详细信息

关键词： immunity al. cancer.

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Enhancer-promoter communication:unraveling enhancer strength and positioning within a given topologically associating domain(TAD)

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3161-3162页

作者： Benedetto Daniele Giaimo Tilman Borggrefe Institute of Biochemistry Justus-Liebig-University GiessenFriedrichstrasse 2435392 GiessenGermany

In a recent study published in Nature,Zuin et *** the molecular mechanisms of how enhancer positioning and strength affect gene expression levels.'Cell-type-specific transcription factors(TFs)and ubiquitously expressed cofactors regulate the complex network of eukar-yotic gene transcription in an exquisitely specific and sensitive *** DNA elements bound by TFs are called enhancers and can be located close to the transcription start site(TSS)or far away.

关键词： al. strength topological

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