Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

作     者：Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Tim Böttrich;Pascal Bauer;Vincent Gröβer;Magdalena Huber;Hartmann Raifer;Torsten Frech;Svenja Nolte;Theresa Dombrowski;Franz Cemic;Natascha Sommer;Robert Ringseis;Klaus Eder;Karsten Krüger;Christopher Weyh

作者机构：Department of Exercise Physiology and Sports TherapyInstitute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and AngiologyJustus-Liebig-University GiessenGiessen 35392Germany Institute for Systems ImmunologyCenter for Tumor und ImmunologyMarburg 35032Germany TH MittelhessenDepartment of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal MedicineUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI)Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition PhysiologyJustus-Liebig-University GiessenGiessen 35390Germany 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第3期

页      面：288-296,I0002页

核心收录：

学科分类：0403[教育学-体育学] 1202[管理学-工商管理] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：funded by the Central Hessen Research Campus Flexi Fund Project No.20121_1_1 

主　　题：Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis 

摘      要：Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.01
1.42))and