Enhancer-promoter communication:unraveling enhancer strength and positioning within a given topologically associating domain(TAD)

作     者：Benedetto Daniele Giaimo Tilman Borggrefe 

作者机构：Institute of BiochemistryJustus-Liebig-University GiessenFriedrichstrasse 2435392 GiessenGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第9期

页      面：3161-3162页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：Open Access funding enabled and organized by Projekt DEAL 

主　　题：al. strength topological 

摘      要：In a recent study published in Nature,Zuin et *** the molecular mechanisms of how enhancer positioning and strength affect gene expression levels. Cell-type-specific transcription factors(TFs)and ubiquitously expressed cofactors regulate the complex network of eukar-yotic gene transcription in an exquisitely specific and sensitive *** DNA elements bound by TFs are called enhancers and can be located close to the transcription start site(TSS)or far away.