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Comparison of Efficacy and Safety between First- and Second-Generation Drug-Eluting Stents in Patients with Acute Coronary Syndrome

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Chinese Medical Journal 2018年第12期131卷 1397-1405页

作者： Yuan-Liang Ma Xiao-Fang Tang Yi Yao Na Xu Ying Song Ping Jiang Jing-Jing Xu Huan-Huan Wang Lin Jiang Ru Liu Xue-Yan Zhao Jue Chen Zhan Gao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： It remains undetermined whether second-generation drug-eluting stents （G2-DESs） outperform first-generation DESs （G1-DESs） in patients with acute coronary syndrome （ACS）. We aimed to compare the efficacy and safety of G I-DES and G2-DES in ACS patients in a high-volume cardiovascular center. Methods： In 2013, 10,724 consecutive patients underwent percutaneous coronary intervention in our institution. We included 4037 patients with ACS who underwent exclusively GI-DES or G2-DES implantation （n - 364 and n - 3673, respectively）. We used propensity score matching to minimize the imbalance between the G1-DES and G2-DES groups and followed patients for 2 years. The efficacy endpoints were major adverse cardiac events （MACEs） and its components including target vessel-related myocardial infarction （TV-MI）, target vessel revascularization/target lesion revascularization （TVR/TLR）, and cardiac death. The safety endpoint was stent thrombosis. Continuous variables were compared by Mann-Whitney U-test, and categorical variables were compared using Pearson＇s Chisquare or Fisher＇s exact test. Kaplan-Meier curves were constructed to compare the event-free survival rates, and multivariate Cox proportional hazards regression analysis was used to assess whether stent type was an independent risk factor for the etticacy and safety endpoints. Results： At the 2-year lbllow-up, the results for MACE and it components, as well as stent thrombosis, were similar for GI-DES and G2-DES （MACE, 5.2% vs. 4.3%,χ^2= 0.514, P= 0.474; TV-M1, 0.8% vs. 0.4%, P 0.407; TVR, 4.9% vs. 3.7%,χ^2=0.939, P 0.333; TLR, 3.8% vs. 2.5%,χ^2=1.610, P = 0.205; cardiac death, 0.3% vs. 0.5%, P= 0.670; and stent thrombosis, 0.5% vs. 0.4%, P 〉 0.999）. Kaplan-Meier analysis indicated similar event-free survival rates between G1-DES and G2-DES alter propensity score matching （all： log-rank P〉 0.05）. Multivariate analysis demonstrated that stent type was not an independent risk factor for the efficacy and safet

关键词： Acute Coronary Syndrome First-Generation Drug-Fluting Stent Percutaneous Coronary Intervention Sccond-Cicncration Drug-Eluting Stent Stent Thrombosis |

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Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction

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Science China(Life sciences) 2022年第3期65卷 631-642页

作者： Bingbing Ke Xin Tan Lu Ren Yangkai Fan Yixin Zhang Fengjuan Li Qiqi Sun Tong Liu Lixin Jia Yuan Wang Jie Du Beijing Collaborative Innovation Centre for cardiovascular Disorders the Key Laboratory of Remodeling-Related Cardiovascular DiseaseMinistry of EducationBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing 100029China Department of cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Serum aldosterone is associated with cardiac remodeling,which contributes to morbidity and mortality in heart failure(HF);however,the prognostic value of aldosterone in HF with a preserved ejection fraction(HFpEF)is *** used liquid chromatography-tandem mass spectrometry to quantify serum aldosterone in 873 patients with HFpEF in a Registry Study of Biomarkers for *** retrospective study was conducted at Beijing Anzhen Hospital from May 2017 to October *** primary endpoint was a composite of all-cause mortality and rehospitalization for *** concentrations in patients with and without events were 124.22 pmol L^(-1)(interquartile range(IQR):48.62–256.20)and 96.33 pmol L^(-1)(IQR:37.33–215.76),respectively(P=0.023).Aldosterone independently predicted all-cause mortality(adjusted hazard ratio(aHR),1.55;95%confidence interval(95%CI),1.06–2.27;P=0.024)and the primary endpoint(a HR,1.43;95%CI,1.11–1.85;P=0.006).Patients with high aldosterone concentrations were at higher risk of concentric remodeling(adjusted odds ratio(aOR),1.45;95%CI,1.03–2.04;P=0.034).Patients with high aldosterone and B-type natriuretic peptide concentrations were at a higher risk of the primary endpoint(hazard ratio(HR),1.85;95%CI,1.29–2.66;P=0.001).We conclude that elevated aldosterone is associated with a risk of rehospitalization with HF and all-cause mortality in patients with HFpEF.

关键词： aldosterone concentric remodeling prognosis HFpEF liquid chromatography-tandem mass spectrometry

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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5727-5768页

作者： Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge Department of cardiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Department of cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Key Laboratory of Viral Heart Diseases National Health CommissionShanghai 200032China Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghai 200032China National Clinical Research Center for Interventional Medicine Shanghai 200032China Shanghai Clinical Research Center for Interventional Medicine Shanghai 200032China Institutes of Biomedical sciences Fudan UniversityShanghai 200032China

Hypoxia,characterized by reduced oxygen concentration,is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular *** the research history and milestone events related to hypoxia in cardiovascular development and diseases,The"hypoxia-inducible factors(HIFs)switch"can be observed from both temporal and spatial perspectives,encompassing the occurrence and progression of hypoxia(gradual decline in oxygen concentration),the acute and chronic manifestations of hypoxia,and the geographical characteristics of hypoxia(natural selection at high altitudes).Furthermore,hypoxia signaling pathways are associated with natural rhythms,such as diurnal and hibernation *** addition to innate factors and natural selection,it has been found that epigenetics,as a postnatal factor,profoundly influences the hypoxic response and progression within the cardiovascular *** this intricate process,interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been ***,it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research,including FDA-approved drugs and ongoing clinical trials,to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases.

关键词： cardiovascular therapeutic organs

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Impact of Residual SYNTAX Score and Its Derived Indexes on Clinical Outcomes after Percutaneous Coronary Intervention：Data from a Large Single Center

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Chinese Medical Journal 2018年第12期131卷 1390-1396页

作者： Ying Song Zhan Gao Xiao-Fang Tang Ping Jiang Jing-Jing Xu Yi Yao Jian-Xin Li Xue-Yan Zhao Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing100037 China

Background： Residual SYNTAX score （rSS） and its derived indexes including SYNTAX revascularization index （SRI） and clinical rSS had been developed to quantify and describe the extent of incomplete revascularization. This study was conducted to explore the utility of the three scores among real-world patients alter percutaneous coronary intervention （PCI）. Methods： From January 2013 to December 2013, patients underwent PCI treatment at Fuwai Hospital were included. Tile primary endpoints were all-cause death and major adverse cardiovascular and cerebrovascular events. The secondary endpoints were myocardial infarction, revascularization, stroke, and stent thrombosis. Kaptan-Meier methodology was used to determine the outcomes. Cox multivariable regression was to test the associations between scores and all-cause mortality. Results： A total of 10,344 patients were finally analyzed in this study. Kaplan-Meier survival analysis indicated that greater residual coronary lesions quantified by rSS and its derived indexes were associated with increased risk of adverse cardiovascular events. However, atier multivariate analysis, only clinical rSS was an independent predictor of 2-year all-cause death （hazard ratio： 1.02, 95% confidence interval： 1.01-1.03, P 〈 0.01）. By receiver operating characteristic （ROC） curve analysis, clinical rSS had superior predictability of 2-year all-cause death than rSS and SRI （area under ROC curve [AUC]： 0.50 vs. 0.56 vs. 0.56, all P 〈 0.01 ）, whereas rSS was superior in predicting repeat revascularization than clinical rSS and SRI （AUC： 0.62 vs. 0.61 vs. 0.61： all P 〈 0.01）. When comparing the predictive capability of rSS 〉8 with SRI 〈70%, their predictabilities were not significantly different.

关键词： Clinical Outcome: Percutaneous Coronary Intervention: Risk Assessment Risk Stratification

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miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction

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Science China(Life sciences) 2013年第5期56卷 431-439页

作者： ZHAO Na YU HaiYi YU HaiTao SUN Min ZHANG YouYi XU Ming GAO Wei Department of cardiology Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthKey Laboratory of Molecular Cardiovascular SciencesMinistry of Education

Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still ***,Pioglitazone attenuated cardiac fibrosis and increased miR-711 *** aimed to explore the role and mechanism of miR-711 in pioglitazone-treated myocardial infarction in *** results showed that pioglitazone significantly reduced collagen-I levels and increased miR-711 expression in myocardial infarction *** increased the expression of miR-711 in cardiac fibroblasts,and overexpression of miR-711 suppressed collagen-I levels in angiotensin II(Ang II)-treated or untreated *** with antagomir-711 correspondingly abolished the pioglitazone-induced reduction in collagen-I *** analysis identified SP1,which directly promotes collagen-I synthesis,as the putative target of *** was confirmed by luciferase assay and western blot ***,increased SP1 expression was attenuated by pioglitazone in myocardial infarction ***,transfection of antagomir-711 attenuated pioglitazone-reduced SP1 expression in cardiac fibroblasts with or without Ang II *** conclude that pioglitazone up-regulated miR-711 to reduce collagen-I levels in rats with myocardial *** miR-711-SP1-collagen-I pathway may be involved in the anti-fibrotic effects of *** findings may provide new strategies for miRNA-based anti-fibrotic drug research.

关键词：心肌纤维化吡格列酮 Ⅰ型胶原心肌梗死心脏成纤维细胞血管紧张素Ⅱ miRNA 小分子RNA

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Applications and grants of National Natural Science Foundation of China’s General program in cardiovascular research:a 10-year review

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Science China(Life sciences) 2023年第3期66卷 649-652页

作者： Juejin Wang Zhaoyang Chen Hongchang Guo Rui Wang Ruijuan Sun Key Laboratory of Targeted Intervention of cardiovascular Disease Department of PhysiologyNanjing Medical UniversityNanjing 211166China Department of cardiology Union HospitalFujian Medical UniversityBeijing 100029China Department of cardiovascular Surgery Center Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100085China Department of Health sciences National Natural Science Foundation of ChinaFuzhou 350001China

cardiovascular diseases(CVDs)are the major threats to global human health and the leading causes of mortality and morbidity in China(Liu et al.,2019).Although various strategies have been developed,the prevalence of CVDs is still increasing in China,and many CVDs cannot be managed well(Liu et al.,2019)because of the lack of full elucidation on many basic issues.

关键词： threat Natural strategies

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The chemokine CCL17 is a novel therapeutic target for cardiovascular aging

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2068-2071页

作者： Yang Zhang Xiaoqiang Tang Zeyuan Wang Lun Wang Zhangwei Chen Ju-Ying Qian Zhuang Tian Shu-Yang Zhang Department of cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai200032China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu610041China

Dear Editor,Aging results in higher susceptibility to age-related disease,especially cardiovascular disease,which has become a public health priority.1,2 Recent studies have progressively unraveled the critical role of vasculature as a gatekeeper of life-span and health-span.3 In this light,vascular rejuvenation is *** circulating proteomic signature is tightly related to aging and aging-induced vascular diseases,4 but drugs targeting circulating proteins are not available.

关键词： aging protective signature

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In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease

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Science China(Life sciences) 2023年第11期66卷 2587-2603页

作者： Shichun Du Linhui Zhai Shu Ye Le Wang Muyin Liu Minjia Tan Department of Endocrinology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesGuangdong 528400China Department of cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China

Diabetic kidney disease(DKD)is a major microvascular complication of type 2 diabetes mellitus(T2DM).Monitoring the early diagnostic period and disease progression plays a crucial role in treating *** this study,to comprehensively elucidate the molecular characteristics of urinary proteins and urinary exosome proteins in type 2 DKD,we performed large-scale urinary proteomics(n=144)and urinary exosome proteomics(n=44)analyses on T2DM patients with albuminuria in varying *** dynamics analysis of the urinary and exosome proteomes in our study provides a valuable resource for discovering potential urinary biomarkers in patients with DKD.A series of potential biomarkers,such as SERPINA1 and transferrin(TF),were detected and validated to be used for DKD diagnosis or disease *** results of our study comprehensively elucidated the changes in the urinary proteome and revealed several potential biomarkers reflecting the progression of DKD,which provide a reference for DKD biomarker screening.

关键词： diabetic kidney disease type 2 diabetes mellitus urinary proteome urinary exosome proteome biomarkers

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Effects of metabolic syndrome on onset age and long-term outcomes in patients with acute coronary syndrome

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World Journal of Emergency Medicine 2021年第1期12卷 36-41页

作者： Jing-jing Xu Ying Song Ping Jiang Lin Jiang Xue-yan Zhao Zhan Gao Jian-xin Li Shu-bin Qiao Run-lin Gao Yue-jin Yang Yin Zhang Bo Xu Jin-qing Yuan Department of cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

BACKGROUND: We aim to investigate effects of metabolic syndrome on onset age and long-termoutcomes in patients with acute coronary syndrome (ACS).METHODS: Patients with ACS (n=6,431) who underwent percutaneous coronary interventionfrom January to December 2013 were enrolled. After excluding patients with previous coronary arterydisease, 1,558 patients were diagnosed with early-onset ACS (men aged ≤50 years;women aged≤60 years) and 3,044 patients with late-onset ACS. Baseline characteristics and five-year clinicaloutcomes were ***: Body mass index, triglyceride, low-density lipoprotein cholesterol, and uric acidconcentrations were significantly higher, while the high-density lipoprotein cholesterol (HDL-C)concentration was lower in the early-onset ACS group (P<0.001). Multivariate logistic regression revealedobesity (odds ratio [OR] 1.590, 95% confi dence interval [CI] 1.345–1.881), hypertriglyceridemia (OR 1.403,95% CI 1.185–1.660), and low HDL-C (OR 1.464, 95% CI 1.231–1.742) as independent risk factorsfor early-onset ACS (all P<0.001). The fi ve-year follow-up showed that the incidences of all cause death(1.5% vs. 3.8%, P<0.001), cardiac death (1.1% vs. 2.0%, P=0.023), and recurrent stroke (2.2% vs. 4.2%,P<0.001) were lower, while bleeding events were more frequent in the early-onset ACS group. A subgroupanalysis showed higher incidences of recurrent myocardial infarction (MI) and revascularization in patientswith early-onset ACS and metabolic ***: Obesity, hypertriglyceridemia, and lower HDL-C level are independent riskfactors for early-onset ACS, recurrent MI, and revascularization. The control of metabolic syndromemay reduce the incidence of early-onset ACS and improve the long-term prognosis.

关键词： Age Coronary artery disease Acute coronary syndrome Metabolic syndrome

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Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population

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Journal of Geriatric cardiology 2021年第1期18卷 39-46页

作者： Qiao QIN Fang-Fang FAN Meng-Yuan LIU Bo LIU Jia JIA Long ZHANG Yu-Xi LI Yi-Meng JIANG Peng-Fei SUN Dan-Mei HE Jian-Ping LI Ming CHEN Bo ZHENG Yan ZHANG Department of cardiology Institute of Cardiovascular DiseasePeking University First HospitalBeijingChina

BACKGROUND Arterial stiffness,as assessed by aortic ultrasound and pulse wave velocity,is associated with incident ***,there is still no consensus on whether the augmentation index(AI)affects new onset of *** study investigated the relationship of radial AI(r AI)and incident hypertension in a Chinese community-based population without hypertension at *** A total of 1,615 Chinese non-hypertensive participants from an atherosclerosis cohort in Beijing,China were included in our *** r AI normalized to heart rate of 75 beats/min(r AIp75)was obtained using HEM-9000 ***-onset hypertension was defined as blood pressure≥140/90 mm Hg or self-reported hypertension or taking anti-hypertensive medications at the follow up *** regression models were used to evaluate the impact of r AIp75 on the risk of new-onset *** After a mean 2.35-year follow-up,213(13.19%)participants developed incident *** significant relation between r AIp75 and incident hypertension was observed in the whole population after adjustment for possible confounders(adjusted odds ratio(OR)and 95%confidence interval(CI):1.09[0.95-1.27];P=0.2260).However,r AIp75 was significantly associated with incident hypertension in women,but not in men(adjusted OR and 95%CI:1.29[1.06-1.56],P=0.0113 for women;0.91[0.72-1.15],P=0.4244 for men;P for interaction=0.0133).CONCLUSIONS Sex modified the effect of the r AI on incident hypertension in a Chinese,community-based,non-hypertensive *** of the r AI could be considered in women with a high risk of hypertension for the purpose of primary intervention.

关键词： Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population

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