Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population

作     者：Qiao QIN Fang-Fang FAN Meng-Yuan LIU Bo LIU Jia JIA Long ZHANG Yu-Xi LI Yi-Meng JIANG Peng-Fei SUN Dan-Mei HE Jian-Ping LI Ming CHEN Bo ZHENG Yan ZHANG Qiao QIN;Fang-Fang FAN;Meng-Yuan LIU;Bo LIU;Jia JIA;Long ZHANG;Yu-Xi LI;Yi-Meng JIANG;Peng-Fei SUN;Dan-Mei HE;Jian-Ping LI;Ming CHEN;Bo ZHENG;Yan ZHANG

作者机构：Department of CardiologyInstitute of Cardiovascular DiseasePeking University First HospitalBeijingChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第1期

页      面：39-46页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the University of Michigan-Peking University Health Science Centre(UMHS-PUHSC)Joint Institute for Translational and Clinical Research and the Fundamental Research Funds for the Central Universities(grant numbers:BMU20110177 and BMU20160530) the National Key Research and Development Program of China(grant number:2017YFC1307704) the Scientific Research Seed Fund of Peking University First Hospital(grant numbers:2018SF003 and 2018SF071) Projects of the National Natural Science Foundation of China(grant number:81703288) the Key Laboratory of Molecular Cardiovascular Sciences(Peking University),Ministry of Education and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides 

主　　题：Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community based population 

摘      要：BACKGROUND Arterial stiffness,as assessed by aortic ultrasound and pulse wave velocity,is associated with incident ***,there is still no consensus on whether the augmentation index(AI)affects new onset of *** study investigated the relationship of radial AI(r AI)and incident hypertension in a Chinese community-based population without hypertension at *** A total of 1,615 Chinese non-hypertensive participants from an atherosclerosis cohort in Beijing,China were included in our *** r AI normalized to heart rate of 75 beats/min(r AIp75)was obtained using HEM-9000 ***-onset hypertension was defined as blood pressure≥140/90 mm Hg or self-reported hypertension or taking anti-hypertensive medications at the follow up *** regression models were used to evaluate the impact of r AIp75 on the risk of new-onset *** After a mean 2.35-year follow-up,213(13.19%)participants developed incident *** significant relation between r AIp75 and incident hypertension was observed in the whole population after adjustment for possible confounders(adjusted odds ratio(OR)and 95%confidence interval(CI):1.09[0.95-1.27];P=0.2260).However,r AIp75 was significantly associated with incident hypertension in women,but not in men(adjusted OR and 95%CI:1.29[1.06-1.56],P=0.0113 for women;0.91[0.72-1.15],P=0.4244 for men;P for interaction=0.0133).CONCLUSIONS Sex modified the effect of the r AI on incident hypertension in a Chinese,community-based,non-hypertensive *** of the r AI could be considered in women with a high risk of hypertension for the purpose of primary intervention.