检索结果-南通市图书馆

Decision-Making and Management of Self-Care in Persons with Traumatic Spinal Cord Injuries: A Preliminary Study

Journal of Behavioral and Brain Science 2024年第2期14卷 47-63页

作者： Paul E. Plonski Jasmin Vassileva Ryan Shahidi Paul B. Perrin William Carter Lance L. Goetz Amber Brochetti James M. Bjork Institute for drug and Alcohol Studies Virginia Commonwealth University Richmond VA USA Richmond Veterans Affairs Medical Center Richmond VA USA Department of Psychiatry Virginia Commonwealth University Richmond VA USA Department of Psychology Virginia Commonwealth University Richmond VA USA Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Richmond VA USA Department of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA Department of Pharmacology and toxicology Virginia Commonwealth University Richmond VA USA

Patients and physicians understand the importance of self-care following spinal cord injury (SCI), yet many individuals with SCI do not adhere to recommended self-care activities despite logistical supports. Neurobehavioral determinants of SCI self-care behavior, such as impulsivity, are not widely studied, yet understanding them could inform efforts to improve SCI self-care. We explored associations between impulsivity and self-care in an observational study of 35 US adults age 18 - 50 who had traumatic SCI with paraplegia at least six months before assessment. The primary outcome measure was self-reported self-care. In LASSO regression models that included all neurobehavioral measures and demographics as predictors of self-care, dispositional measures of greater impulsivity (negative urgency, lack of premeditation, lack of perseverance), and reduced mindfulness were associated with reduced self-care. Outcome (magnitude) sensitivity, a latent decision-making parameter derived from computationally modeling successive choices in a gambling task, was also associated with self-care behavior. These results are preliminary;more research is needed to demonstrate the utility of these findings in clinical settings. Information about associations between impulsivity and poor self-care in people with SCI could guide the development of interventions to improve SCI self-care and help patients with elevated risks related to self-care and secondary health conditions.

关键词： Spinal Cord Injury Self-Care Decision-Making Paraplegia Impulsive Behavior Health Care

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymorphisms of the oxidant enzymes glutathione S-transferase and glutathione reductase and their association with resistance of Plasmodium falciparum isolates to antimalarial drugs

引用

Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 673-677页

作者： Raewadee Wisedpanichkij Wanna Chaicharoenkul Poonuch Mahamad Prapichaya Prompradit Kesara Na-Bangchang Pharmacology and toxicology unit Graduate Program in Biomedical SciencesThammasat UniversityThailand

Objective:To investigate the association between amplification of the two regulatory genes controlling glutathione(GSH) levels,glutathione reductase(PfGR) and glutathione S-transferase (PfGST) genes and sensitivity of Plasmodium falciparum(***) isolates collected from different malaria endemic areas of Thailand to standard antimalarial ***:A total of 70 *** isolates were collected from endemic areas of multi-drug resistance (Tak,Chantaburi and Ranong Provinces) during the year *** in vitro assessment of antimalarial activity of *** clones(K1- and Dd2 chloroquine resistant and 3D7- chloroquine sensitive) and isolates to chloroquine,quinine,mefloquine and arteusnate was performed based on SYBR Green modified ***:68(97.14%),11(15.71%) and 28(40%) isolates respectively were classified as chloroquine-,quinine- and mefloquine-resistant isolates. With this limited number of *** isolates included in the analysis,no significant association between amplification of PfGST gene and sensitivity of the parasite to chloroquine, quinine,mefloquine and quinine was *** on PCR analysis,Dd2,Kl and 3D7 clones all contained only one copy of the PfGST *** isolates(70) also carried only one copy number of PfGST *** appears to be an association between amplification of PfGR gene and chloroquine *** 3D7 and Dd2 clones were found to carry only one PfGR gene copy, whereas the K1 clone carried two gene ***:Chloroquine resistance is likely to be a consequence of multi-factors and enzymes in the GSH system may be partly involved. Larger number of parasite isolates are required to increase power of the hypothesis testing in order to confirm the involvement of both genes as well as other genes implicated in glutathione metabolism in conferring chloroquine resistance.

关键词： Plasmodium falciparum drug resistance Glutathione reductase(PfGR) Glutathione S-transferase(P/GST)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies

引用

Neural Regeneration Research 2017年第3期12卷 403-404页

作者： Lorenzo Di Cesare Mannelli Carla Ghelardini Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Neuropathic pain originates from damages to the somatosensory nervous system（IASP-International Association for the Study of Pain-taxonomy）.Lesions（traumas,compression,iatrogenic and pharmacological causes）or dise... 详细信息

关键词： Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies EFSA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

引用

Neural Regeneration Research 2022年第9期17卷 1913-1918页

作者： Heba M.Mansour Hala M.Fawzy Aiman S.El-Khatib Mahmoud M.Khattab Department of Pharmacology Egyptian Drug AuthorityEDAformerly NODCARGizaEgypt Department of Pharmacology and toxicology Faculty of PharmacyCairo UniversityCairoEgypt

Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s *** studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer’s *** the promising effects of epidermal growth factor receptor inhibitors in Alzheimer’s disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling *** caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical *** this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer’s disease will be ***,their molecular mechanisms in neurodegeneration will be ***,we will shed light on SARS-COVID-19 induced neurological manifestations mediated by epidermal growth factor ***,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more *** conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer’s disease progression.

关键词： Alzheimer’s disease autophagy drug re-positioning epidermal growth factor receptor human epidermal growth factor receptor-2 neurodegenerative diseases neuroinflammation oxidative stress tyrosine kinase inhibitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

引用

Acta Pharmaceutica Sinica B 2022年第4期12卷 1761-1780页

作者： Tiecheng Zhong Wenxin Zhang Hongjie Guo Xiaohui Pan Xi Chen Qiaojun He Bo Yang Ling Ding Zhejiang Province Key Laboratory of Anti-Cancer drug Research Institute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal ***,however,accumulating evidence shows that those TRP channels are also responsible for tumorigenesis and progression,inducing tumor invasion and ***,the overall underlying mechanisms and possible signaling transduction pathways that TRP channels in malignant tumors might still remain ***,in this review,we focus on the linkage between TRP channels and the significant characteristics of tumors such as multi-drug resistance(MDR),metastasis,apoptosis,proliferation,immune surveillance evasion,and the alterations of relevant tumor ***,we also have discussed the expression of relevant TRP channels in various forms of cancer and the relevant inhibitors’*** chemo-sensitivity of the anti-cancer drugs of various acting mechanisms and the potential clinical applications are also ***,it would be enlightening to provide possible novel therapeutic approaches to counteract malignant tumors regarding the intervention of calcium channels of this type.

关键词： TRP channels Cancer progression Tumor microenvironment Tumor-associated immunocytes Intracellular mechanism Programmed cancer cell death Targeted tumor therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses

引用

Acta Pharmaceutica Sinica B 2020年第5期10卷 723-733页

作者： Xi Chen Xiaohui Pan Wenxin Zhang Hongjie Guo Shuyuan Cheng Qiaojun He Bo Yang Ling Ding Zhejiang Province Key Laboratory of Anti-Cancer drug Research Institute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Immunotherapy strategies targeting the programmed cell death ligand 1(PD-L1)/programmed cell death 1(PD-1)pathway in clinical treatments have achieved remarkable success in treating multiple types of ***,owing to the heterogeneity of tumors and individual immune systems,PD-L1/PD-1 blockade still shows slow response rates in controlling malignancies in many *** evidence has shown that an effective response to anti-PD-Ll/anti-PD-1 therapy requires establishing an integrated immune *** in any step of the immune cycle is one of the most important causes of immunotherapy *** in the immune cycle can be restored by epigenetic modification,including reprogramming the environment of tumor-associated immunity,eliciting an immune response by increasing the presentation of tumor antigens,and by regulating T cell trafficking and ***,a rational combination of PD-L1/PD-1 blockade and epigenetic agents may offer great potential to retrain the immune system and to improve clinical outcomes of checkpoint blockade therapy.

关键词： Epigenetic regulation Immune cycle PD-L1PD-1 blockade Cancer Immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncogenes, Oncogenesis, and Oxygen Radicals

引用

Biomedical and Environmental Sciences 1990年第2期3卷 183-201页

作者： SAURA C.SAHU Molecular toxicology Laboratory Division of Toxicological Studies Food and Drug Administration Washington D.C. 20204

The role that free radicals in general and oxygen radicals in particular play in carcinogenesis has attracted considerable attention in recent years. The oxygen radicals are undesirable but inevitable products of aerobic metabolism in the normal living cell. The cellular antioxidant defense system maintains an appropriate balance between necessary oxidative events and those that are excessive. When this critical balance cannot be maintained because of the overloading of the cellularredox system, oxygen radicals can induce cell damage. They can influence carcinogenesis by inducing DN A damage from direct oxidation or indirectly from DNA-binding products of lipid peroxidation. Oxygen radicals can induce conformational changes in the plasma membrane by lipid peroxidation and protein degradation, thus influencing membrane-associated cellular activities. They are capable of affecting membrane-bound protein kinases, growth factors and their receptors, and, therefore, signal transduction and oncogene activation. Thus, the oxygen radicals can have a major influence on oncogenes and oncogenesis. (C)1990 Academic ***.

关键词： gene and Oxygen Radicals Oncogenes Oncogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cannabinoid CB1 receptors are expressed in a subset of dopamine neurons and underlie cannabinoid modulation of DA release and DA-related behavior in mice

引用

中国药理学与毒理学杂志 2023年第7期37卷 535-536页

作者： HAN Xiao WU Ning XI Zhengxiong LI Jin Beijing Key Laboratory of Neuropsychopharmacology State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology Addiction Biology unit Molecular Targets and Medications Discovery Branch Intramural Research Program National Institute on Drug Abuse

OBJECTIVE Cannabinoids modulate dopamine(DA) transmission and DA-related behavior,which has been thought to be mediated initially by activation of cannabinoid CB1 receptors(CB1Rs) on GABA neurons. However, the cellular and receptor mechanisms underlying cannabinoids′ psychoactive effects are not fully understood. The present study is to explore the possible expression character of CB1Rs and elucidated the underlying mechanism of them. METHODS We took advantage of RNAscope in situ hybridization(ISH)assays and triple-staining assays to detect the CB1Rexpressing neurons. We established an optical intracranial self-stimulation(OICSS) behavioral model by using optogenetics to study dopaminergic reinforcement *** and synthetic cannabinoids were used to study the function of CB1Rs. Conditional genetic depletion of CB1Rs and behavioral assay were performed to study the modulatory role of CB1Rs in DA-related *** We found that CB1Rs are also expressed in a subset of DA neurons and functionally underlie cannabinoid action in male and female mice. ISH assays demonstrated CB1 mRNA in tyrosine hydroxylase(TH)-positive DA neurons in the ventral tegmental area(VTA) and glutamate decarboxylase 1(GAD1)-positive GABA neurons. The CB1R expressing DA neurons were located mainly in the middle portion of the VTA with the number of CB1-TH colocalization progressively decreasing from the medial to the lateral VTA. Triple-staining assays indicated CB1R mRNA colocalization with both TH and vesicular glutamate transporter 2(VgluT2, a glutamate neuronal marker) in the medial VTA close to the midline of the brain. Optogenetic activation of this population of DA neurons was rewarding as assessed by OICSS.D9-tetrahydrocannabinol(D9-THC) or ACEA(a selective CB1R agonist) dose-dependently inhibited optical intracranial self-stimulation in DAT-Cre control mice, but not in conditional knockout mice with the CB1R gene absent in DA neurons. In addition, deletion of CB1Rs from

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Role of Soluble Factors in Immune and Normal Sera in the Control of Giardiasis Due to Giardia Iamblia

引用

Biomedical and Environmental Sciences 1992年第2期5卷 87-91页

作者： R.K.SRIVASTAVA N.SETHI N.GUPTA A.K.AGARWAL Division of toxicology Division of ToxicologyMicrobiology Central Drug Research Institute LucknowMicrobiology Central Drug Research Institute Lucknow Offprint request to Dr. (Mrs). N. Sethi Scientist-in-Charge226001. India226001. India

Hyperimmune sera (HIS), raised against crude giardia antigen, on in vitro interaction, caused more agglutination of Giardia lamblia trophozoites. Heat inactivated HIS possessed a comparable agglutinating activity as the non-inactivated controls. Non-inactivated normal (unimmunized) serum caused immobilization of Giardia trophozoite, which was checked on heat inactivation. Antibodies in immune sera are mainly responsible for agglutination, whereas the heat labile non-immune components control the mobility of the intestinal parasite.

关键词： Role of Soluble Factors in Immune and Normal Sera in the Control of Giardiasis Due to Giardia Iamblia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reverse pharmacokinetics guided target identification and mechanistic understanding of Chinese medicines

引用

中国药理学与毒理学杂志 2017年第10期31卷 949-950页

作者： Hai-ping HAO Key Laboratory of drug metabolism and Pharmacokinetics Center for Instrument Analysis China Pharmaceutical University Nanjing 210009 China

Natural medicines (NMs) are indispensable sources for the development of modern drugs. However, the targets for most natural compounds are unknown and the current pharmacokinetic evaluation systems developed for target- defined drugs may not be directly applicable to NM- based drug discovery, which is a major bottleneck in bringing natural compounds to the clinic. We propose the concept of ″ reverse pharmacokinetics″ and discuss how a ″ reverse pharmacokinetics″ perspective could help clarify key questions in modern drug discovery from NMs with validated clinical benefits, thereby strengthening the translational potential. Reverse pharmacokinetics can provide physiologically relevant clues to the target identification and mechanistic study of NMs, which may also innovate drug discovery for complex diseases. We anticipate that an evolving deep understanding of the novel mode of action of natural compounds with a reverse pharmacokinetic insight may improve discovery of both single ingredient and multiple-component modern drugs from NMs.

关键词： natural medicines target-defined drugs reverse pharmacokinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：