Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

作     者：Heba M.Mansour Hala M.Fawzy Aiman S.El-Khatib Mahmoud M.Khattab Heba M.Mansour;Hala M.Fawzy;Aiman S.EI-Khatib;Mahmoud M.Khattab

作者机构：Department of PharmacologyEgyptian Drug AuthorityEDAformerly NODCARGizaEgypt Department of Pharmacology and ToxicologyFaculty of PharmacyCairo UniversityCairoEgypt 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第9期

页      面：1913-1918页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Alzheimer’s disease autophagy drug re-positioning epidermal growth factor receptor human epidermal growth factor receptor-2 neurodegenerative diseases neuroinflammation oxidative stress tyrosine kinase inhibitors 

摘      要：Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s *** studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer’s *** the promising effects of epidermal growth factor receptor inhibitors in Alzheimer’s disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling *** caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical *** this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer’s disease will be ***,their molecular mechanisms in neurodegeneration will be ***,we will shed light on SARS-COVID-19 induced neurological manifestations mediated by epidermal growth factor ***,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more *** conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer’s disease progression.